105,731 research outputs found
Vortex Vein Imaging: What Can It Tell Us?
No full textAditya Verma,1,2 Tommaso Bacci,3,4 David Sarraf,5 K Bailey Freund,3,4 SriniVas R Sadda1,2 1Doheny Eye Institute, Los Angeles, CA, USA; 2Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 3Vitreous Retina Macula Consultants of New York, New York, NY, USA; 4Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, USA; 5Stein Eye Institute, David Geffen School of Medicine at University of California, Los Angeles, CA, 90095, USACorrespondence: SriniVas R Sadda Email [email protected]: This review article summarizes the patho-anatomy of the vortex veins, the major drainage channels for the choroid, and describes the various pathways of diseases associated with vortex vein abnormalities. This report also details the technical advancements to image the vortex veins, such as ultra-widefield indocyanine green angiography, which are critical to elucidate the importance of the vortices in various retino-choroidal disorders. Future applications of these advanced imaging systems to better understand the role of the vortex veins in health and disease are also discussed.Keywords: choroid, optical coherence tomography angiography, pachychoroid disease, ultra-widefield imaging, vortex vein
Medicaid, Managed Care, and Kids. 12th Annual Herbert Lourie Memorial Lecture on Health Policy
No full textThis policy brief talks about what managed care for Medicaid is, how it influences kids, and how it relates to the State Child Health Insurance Program (CHIP). It focuses on what we have learned over the last 20 years through research about cost, use, and quality. It also discusses some of the expectations we had for children covered by Medicaid managed care. Finally, it talks abaout the future of Medicaid managed care and the implications for CHIP.
Contribution à l'histoire des Idées politiques. A propos de Arnold A. T. Ehrhardt, Politische Metaphysik von Solon bis Augustin, 1959.
No full textFreund Julien. Contribution à l'histoire des Idées politiques. A propos de Arnold A. T. Ehrhardt, Politische Metaphysik von Solon bis Augustin, 1959. In: Revue d'histoire et de philosophie religieuses, 40e année n°1,1960. Le Problème de la Tradition. pp. 58-64
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Peptide in Incomplete Freund Adjuvant
No full textExperimental autoimmune encephalomyelitis in the neotropical primate common marmoset (Callithrix jacchus) is a relevant autoimmune animal model of multiple sclerosis. T cells specific for peptide 34 to 56 of myelin/oligodendrocyte glycoprotein (MOG(34-56)) have a central pathogenic role in this model. The aim of this study was to assess the requirement for innate immune stimulation for activation of this core pathogenic autoimmune mechanism. Marmoset monkeys were sensitized against synthetic MOG(34-56) peptide alone or in combination with the nonencephalitogenic peptide MOG(74-96) formulated in incomplete Freund adjuvant, which lacks microbial components. Experimental autoimmune encephalomyelitis development was recorded by monitoring neurological signs, brain magnetic resonance imaging, and longitudinal profiling of cellular and humoral immune parameters. All monkeys developed autoimmune inflammatory/demyelinating central nervous system disease characterized by massive brain and spinal cord demyelinating white matter lesions with activated macrophages and CD3(+) T cells. Immune profiling ex vivo demonstrated the activation of mainly CD3(+)CD4(+)/8(+)CD56(+) T cells against MOG(34-56). Upon ex vivo stimulation, these T cells produced more interleukin 17A compared with TH1 cytokines (e. g. interferon-gamma) and displayed peptide-specific cytolytic activity. These results indicate that the full spectrum of marmoset experimental autoimmune encephalomyelitis can be induced by sensitization against a single MOG peptide in incomplete Freund adjuvant lacking microbial compounds for innate immune activation and by eliciting antigen-specific T-cell cytolytic activity
INFRARED-RADIOFREQUENCY TWO-PHOTON LAMB DIP SPECTROSCOPY OF AND
No full text S.M. Freund and T. Oka, Appl. Phys. Lett. 21, 60 (1972).Author Institution: Division of Physics, National Research Council of CanadaThe two-photon Lamb dip technique previously applied to ammonia using infrared and microwave is now extended to the radio-frequency region. If a rotational level of a symmetric top molecule with has double parity, a radiofrequency photon can be ``added” directly to an infrared laser photon using the non-linearlity of the molecular transition process. The two-photon Lamb dips observed are listed below. [FIGURE] The observation gives the difference between the laser lines and molecular absorptions with an accuracy of about 0.5 MHz. Precision molecular constants which supplement recent laser-Stark spectroscopy on are obtained. M. R\”omheld was the holder of a German Academic Exchange Service Fellowship
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Freund-schaft: Capturing Aura in an Unframed Literary Exchange
No full textThis dissertation charts an intellectual history of collaborations centered on the beginning of socio-critical discourse on photography. I study the critically misread oeuvre of photographer and sociologist Gisèle Freund to reconfigure a transatlantic map of concrete personal, literary, and critical connections during the 1930s and ’40s. In examining Freund’s oeuvre, I suggest a crucial intervention on the notion of aura — Walter Benjamin’s trademark for understanding the dialectics of the original and its reproduction. I advance a reading in support of aura that challenges the canonical “The Work of Art in the Age of Technical Reproducibility” (1940) of Benjamin. The continuous coexistence of the terms aura, market, and photography is present in Freund – author of iconic photo-portraits of writers such as James Joyce, Virginia Woolf, André Malraux, Jorge Luis Borges or Benjamin. It contests the reduction of the original’s aura and its reproduction to mutually exclusive terms. My counter-reading in fact recovers the prior and wider aura integral to Benjamin’s “Little History of Photography” (1931). It is this cardinal yet neglected piece that inaugurated together with Freund’s La Photographie en France au dix-neuvième siècle (1936) the critical discourse on photography. Walter Benjamin’s presence is dynamically ingrained in Freund’s oeuvre. In addition to their friendship, two additional friends inform Freund’s career. Freund’s mentors were the leading cultural agents in Paris and Buenos Aires: Adrienne Monnier, the legendary French publisher of Joyce’s Ulysses, and Victoria Ocampo, the founding director of Sur, one of the key literary journals in Latin America. The network of cooperative interactions here deployed is conjugated under the critical metaphor Freund-schaft. Coined on Freund’s name, the term draws equally on the meaning of friendship and the creative making contained in the suffix –schaft (derived from the German schaffen, “to make”, “to create”, “to accomplish”). The framework hinges on the tension between history and theory. Freund-schaft brings to light omissions, conjunctions, and the debates that make up the larger structure of feelings, and makes particulars inextricable from a life-woven net
Julien Freund : philosophie de la résistance
No full textJulien Freund (1921-1993) disait de son maître ouvrage, L'Essence du politique (1965), qu'il était le résultat d'une déception surmontée. De quelle déception s'agit-il et comment a-t-elle orienté le développement de sa pensée ? Voilà l'interrogation qui a guidé notre recherche. Notre premier chapitre aborde les années de préparation de l'œuvre de Freund, de son expérience de la Résistance aux lectures qui l'ont influencé : Aristote, Machiavel, Weber, Schmitt et Aron. Notre deuxième chapitre présente et explique les principaux arguments de L'Essence du politique, qui nous permettront de mieux comprendre la critique freundienne de l'utopisme dont nous parlerons dans notre troisième chapitre. Notre dernier chapitre explore les dimensions philosophique et anthropologique de l'œuvre freundienne. Au terme de ce développement, nous serons en mesure d'identifier la dynamique particulière de la pensée de Julien Freund, dynamique qui implique de façon essentielle la notion de résistance
Kv1 channels in signal conduction of myelinated nerve fibers
No full textPubMedID: 16878404The myelinated axon can be divided into three domains: the internodal axon, the paranodal axon and the nodal axon. The internodal axolemma contains high concentrations of K+ channels that are enriched in the juxtaparanodal region, whereas Na+ channels cluster in the node. This molecular organization of the myelinated axon membrane is critically important for the rapid and successful transmission of electrical impulses. The juxtaparanodal K+ channels are believed to be electrically inactive in adult peripheral nerves, but experiments with blocking drugs and genetic deletion have shown that they may serve important functions at earlier developmental stages, and during remyelination and regeneration. © Freund & Pettman, U.K.SBAG-2554The author thanks Dr. Ismail Gunay for advice and critical assessment of the manuscript, and the many investigators whose work is reviewed here. Work in the author's laboratory has been supported by grants from the Scientific and Technical Research Council of Turkey (SBAG-2554) and Research Foundation of Cukurova University
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