1,363 research outputs found
Liftings for noncomplete probability spaces
No full textThe current state of knowledge concerning liftings for noncomplete probability spaces is discussed. This is a somewhat expanded version of the author's talk given at the 1991 Summer Conference on General Topology and Applications in Honor of Mary Ellen Rudin and Her Work.PT: S; CR: BURKE MR, IN PRESS P AM MATH S BURKE MR, 1991, ISRAEL J MATH, V73, P33 BURKE MR, 1992, ISRAEL J MATH, V79, P289 CARLSON T, THEOREM LIFTING CHRISTENSEN JPR, 1974, TOPOLOGY BOREL STRUC FREMLIN DH, 1989, HDB BOOLEAN ALGEBRAS, P877 INOESCUTULCEA A, 1966, 5TH P BERK S MATH ST, V2 IONESCUTULCEA A, 1967, CONTRIBUTIONS PROB 1, P63 IONESCUTULCEA A, 1969, TOPICS THEORY LIFTIN JECH TJ, 1978, SET THEORY JOHNSON RA, 1980, P AM MATH SOC, V80, P234 JUST W, IN PRESS T AM MATH S KUPKA J, 1983, INDIANA U MATH J, V32, P717 LOSERT V, 1983, LNM, V1080, P95 MAHARAM D, 1958, P AM MATH SOC, V9, P987 SHELAH S, 1983, ISRAEL J MATH, V45, P90 TALAGRAND M, 1982, P AM MATH SOC, V84, P379 VONNEUMANN J, 1931, CRELLES J MATH, V165, P109; NR: 18; TC: 0; J9: ANN N Y ACAD SCI; PG: 4; GA: BZ86BSource type: Electronic(1
Using omics in chronic pain conditions to delineate mechanisms and provide new therapeutic strategies
No full textPROBLEM OF A RATIO OF THE POINTS OF VIEW IN THE NOVEL “FOMA GORDEYEV” BY MAXIM GORKY
No full textVarious points of view of the characters of the novel “Foma Gordeyev” by Maxim Gorky come
to light and are analysed in the article, their complicated ratio supported by certain motives – work or business, dissociation, loneliness, enrichment and search of the place in life – is considered. It is proved that the
ratio of the characters’ points of view understood by the author as positions, from which events are considered, is among the bright artistic touches of early works of Maxim Gorky. This inclusion in the Fin de siècle
era, time of the overall overturn and of the new judgement of many concepts could be used in connection
with unwillingness of Maxim Gorky’s open expression of his author’s opinion. Composing a fancy plot, bringing heroes together, the
writer offers the sooth at the reader’s discretion rather than making emphases. The narrator’s voice is dominating, beginning and finishing the epic narration, at the same time only framing various points of view of the characters. The polyphony of the novel and the
thought-over ratio between the author, the storyteller and the heroes allowed Maxim Gorky creating gallery of living, spatial characters,
emphasising dramatic bases of the Russian life of the represented period and reducing all voices to a uniform denominator. The ratio
of the heroes’ points of view becomes one of the bases of the work’s composition and leads to understanding of the reasons of failures
of many characters. The author of the article analyses ways of introducing the speaking people’s images to the artistic text, emphasises
existence of the special sayings for all occasions in the text designed to influence the recipient by the offer of “wisdom formulas” to it,
only to be taken stock of by the reader. Most likely, the ratio of the points of view in the novel as a special device had, on the one hand,
already been preconditioned, and, on the other hand, could affect a peculiar mosaicity of the upcoming Maxim Gorky’s personal artistic
method. Moreover, features of the narration and substantial aspects of composition allow us saying that in the novel “Foma Gordeyev”,
Maxim Gorky creatively masters and actively uses findings of the Russian classics of the second half of the 19th century
170226 ELDER CARE EVENT BEARD 007
No full textProfessor Laura Olson, a member of the Political Science department at Lehigh, listens to her audience on Wednesday, Feb. 22, 2017 in Williams Hall. Olson is the author of "Elder Care Journey: A View from the Front Lines" (Maxim Beard/B&W Staff
170226 ELDER CARE EVENT BEARD 003
No full textProfessor Laura Olson, author of "Elder Care Journey: A View from the Front Lines", talks during a Brown Bag Series on Wednesday, Feb. 22, 2017 in Williams Hall. Olson is a professor of Political Science at Lehigh. (Maxim Beard/B&W Staff
170226 ELDER CARE EVENT BEARD 005
No full textProfessor Laura Olson, author of "Elder Care Journey: A View from the Front Lines", speaks during a Brown Bag Series on Wednesday, Feb. 22, 2017 in Williams Hall. Olson passionately discussed her personal experience with the long-term care system in the U.S. (Maxim Beard/B&W Staff
Genome-wide association summary statistics for sex- and age-specific analysis of chronic back pain
No full textThe dataset comprises summary-level statistics for age- and sex-specific genome-wide association study of chronic back pain (cBP) in individuals of European descent from UK Biobank (https://www.ukbiobank.ac.uk/). The study was carried out under UK Biobank approved project #18219.
The dataset accompanies the paper (please cite if using the dataset):
Freidin, Maxim B.; Tsepilov, Yakov A.; Stanaway, Ian B.; Meng, Weihua; Hayward, Caroline; Smith, Blair H.; Khoury, Samar; Parisien, Marc; Bortsov, Andrey; Diatchenko, Luda; Børte, Sigrid; Winsvold, Bendik S.; Brumpton, Ben M.; Zwart, John-Anker; HUNT All-In Pain; Aulchenko, Yurii S.; Suri, Pradeep; Williams, Frances M.K. Sex- and age-specific genetic analysis of chronic back pain. Pain. 2020. doi:10.1097/j.pain.0000000000002100.
The phenotype of cBP was defined as back pain for 3+ months. Linear mixed-effects additive model was fitted adjusting for age, genotyping array type, and 10 genetic PCs provided by UK Biobank. The following filters were applied: minor allele frequency >0.001, genotyping and individual call rates >0.98%, imputation quality score (INFO) >0.7. GWAS were carried out in males and females separately in the whole sample (allages) as well as in groups of younger than 65 years (under65) and 65+ years old (65plus) as detailed in the paper. Accordingly, 6 files are deposited here, corresponding to each group.
Column headers:
SNP, SNP rsID
CHR, chromosome
BP, genomic position (GRCh37 build)
EA, effect allele (coded as "1")
OTHER, other allele (coded as "0")
A1FREQ, frequency of effect allele
INFO, imputation quality
BETA, effect size (for effect allele)
SE, standard error of effect size
PVAL, p-value for associatio
The Association Between Low Back Pain and Composition of IgG Glycome
Full text linkLow back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out a first so far analysis of associations between LBP and plasma IgG N-glycome in a sample of 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, and IgG-glycan levels. Using weighted correlation network analysis, we established a correlation between LBP and glycan modules featured by glycans that either promote or block antibody-dependent cell-mediated cytotoxicity (ADCC). The levels of four glycan traits representing two of those modules were statistically significantly different in monozygotic twins discordant for LBP. Also, the trend to higher prevalence of systemic inflammatory disorders was shown for twins with low level of fucosylated glycans and high level of non-fucosylated glycans. Core fucosylation of IgG is a "safety switch" reducing ADCC, thus our results suggest the involvement of ADCC and associated inflammation in pathogenesis of LBP. No correlation between LDD scores and glycans was found assuming that the inflammation may not be a part of LDD. These data provide a new insight into understanding the complex pathophysiology of LBP and suggest glycan levels as a possible biomarker for inflammation-related subtypes of LBP
An RNA interference knock-down of nitrate reductase enhances lipid biosynthesis in the diatom Phaeodactylum tricornutum
No full textWhen diatoms are stressed for inorganic nitrogen they remodel their intermediate metabolism and redirect carbon towards lipid biosynthesis. However, this response comes at a significant cost reflected in decreased photosynthetic energy conversion efficiency and growth. Here we explore a molecular genetics approach to restrict the assimilation of inorganic nitrogen by knocking down nitrate reductase (NR). The transformant strain, NR21, exhibited about 50% lower expression and activity of the enzyme but simultaneously accumulated over 40% more fatty acids. However, in contrast to nitrogen-stressed wild-type (WT) cells, which grow at about 20% of the rate of nitrogen-replete cells, growth of NR21 was only reduced by about 30%. Biophysical analyses revealed that the photosynthetic energy conversion efficiency of photosystem II was unaffected in NR21; nevertheless, the plastoquinone pool was reduced by 50% at the optimal growth irradiance while in the WT it was over 90% oxidized. Further analyses reveal a 12-fold increase in the glutamate/glutamine ratio and an increase NADPH and malonyl-CoA pool size. Transcriptomic analyses indicate that the knock down resulted in changes in the expression of genes for lipid biosynthesis, as well as the expression of specific transcription factors. Based on these observations, we hypothesize that the allocation of carbon and reductants in diatoms is controlled by a feedback mechanism between intermediate metabolites, the redox state of the plastid and the expression and binding of transcription factors related to stress responses.Peer reviewe
Contribution of Citizen Science to Biodiversity Data Mobilization in Russia
No full textPresentation for TDWG 2020 - A Virtual Conference
Session: CO03, 22 October 2020
Conference Abstract: https://doi.org/10.3897/biss.4.59197
video: https://youtu.be/dOp6j69qxT4Presenting author: Maxim Shashko
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