1,720,960 research outputs found
Espressione di biomarcatori specifici del cemento nel fluido crevicolare gengivale a diversi intervalli di guarigione dopo la rigenerazione parodontale: studio prospettico controllato
No full textAim: Periodontal regeneration requires full knowledge of the timing and quantity of expression of cell signaling proteins that guide the formation of new periodontal tissues. Levels of cytokines, chemokines, and angiogenic biomarkers within the gingival crevicular fluid and in periodontal wound fluid have been studied in clinical trials to assess the ongoing angiogenesis, connective tissue, and bone formation activities during wound-healing phases. In clinical practice, the evaluation of cementogenesis by analysis of wound fluid can be useful to predict the success of periodontal regeneration and to support the development of further regenerative approaches. Cementum protein-1 (CEMP-1) and Cementum attachment protein (CAP) are found to be a tissue-specific protein for cementum and are believed to regulate the biological activity of cementum and periodontal cells. The aim of the present study was to assess if regenerative periodontal surgery might affect levels of CEMP-1 and CAP in periodontal wound fluid during initial healing.
Materials and Methods: In 8 patients, who met the inclusion criteria,11 intrabony periodontal defects ≥3mm associated with periodontal pockets >5mm were treated with regenerative therapy. Each patient also contributed 1 healthy site as a control.
The surgical technique involved a minimally invasive approach with papilla preservation and use of deproteinized bovine bone and amelogenins. Crevicular fluid sampling was performed before surgery, at 15 days, at 3, 4, 6, 8 weeks. Clinical and radiographic data were recorded at T0 and 6 months. CEMP-1 and CAP levels were detected by indirect enzyme-linked immunosorbent assay technique.
Results: The repeated measures-ANOVA for CEMP-1 concentration levels in the treated tooth throughout the treatment shows a statistically significant difference between the values (F[5, 50]=6.50, p <.001). In addition, trend analysis confirms a linear trend, indicating a consistent pattern of change over time (t = 3.964, p = .003). No statistically significant difference was found between CEMP-1 concentrations in the treated tooth and in the control (p = .831, and p = 123, respectively).
The repeated measures-ANOVA for the CAP concentration levels in the treated tooth throughout the treatment shows a statistically significant difference between the values (F[5, 50]=3.38, p = .005). There is both a statistically significant difference in CAP concentrations in treated teeth between BL and W8 (p = .007) and a linear trend in trend analysis (t = 5.261, p < .001). A statistically significant difference could be observed between CAP concentrations between BL-treated and control sites (p =.014). Conclusions: The results – in terms of differences between the concentrations between the various samples obtained from the test sites, and between BL and W8 values – suggest that the concentration of CEMP-1 in the treated tooth may reflect the response to treatment. However, despite this observable variation, the lack of a direct correlation between this variation and clinical improvement of the treated tooth may limit the usefulness of CEMP-1 as an indicator of therapeutic success. On the contrary - regarding CAP - we were able to observe both the same differences in terms of concentration previously described for CEMP-1, with in addition, a relationship between the reduction of differences in CAP levels and the clinical data of improvement; this framework would support the hypothesis that CAP can be a reliable indicator of therapeutic efficacy
The Multilayer GBR Technique: An Alternative Approach for One-Stage Transmucosal Implant Placement in the Presence of Horizontal Defects. A Case Series
No full textThis study presents a one-stage technique for horizontal guided bone regeneration and transmucosal implant placement in the presence of hard and soft tissue defects. The proposed technique uses autologous bone particles, deproteinized bovine bone matrix, collagen membranes, and concentrated growth factor membranes to create a multilayer barrier and enhance tissue regeneration. Four patients were treated with a total of seven implants. Digital analyses of intraoral scan data taken at baseline and at 6 months postsurgery showed a mean increase in tissue volume of 157.4 mm(3). The patient satisfaction was high, and no complications were observed
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Diagnostic Accuracy of Urinary Biomarkers in Periodontitis: A Systematic Review and Meta-Analysis
Get PDFBackground. Biomarkers can be measured in various biological samples. Urine is among the most useful biofluids for routine testing, and several experimental and clinical studies support its role as a tool for the diagnosis and prevention of various diseases. The present systematic review aimed to examine periodontitis-specific urine biomarkers that could have a diagnostic relevance and to provide a qualitative assessment of the current literature. Materials and Methods. Relevant studies identified from PubMed, Embase, Cochrane Library, and Scopus databases were examined to answer the following PECO question: “Could the concentration of specific metabolites in the urine be related to periodontal health and what is their diagnostic accuracy?”. Quality of included studies was rated using ROBINS-I tool. Meta-analysis was conducted on available quantitative data. Results. After the screening of 768 titles, five studies were included in qualitative synthesis. The studies included referred to the evaluation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and neopterin. Meta-analysis was conducted for neopterin concentration on data available in four studies involving 129 participants. Higher concentrations of neopterin were found in periodontitis-affected patients compared to controls and patients treated for periodontitis. Conclusions. The literature appears controversial in attributing a role to neopterin and 8-OHdG as periodontal biomarkers, highlighting the need for further clinical studies on this topic. While some studies report variations in 8-OHdG and neopterin levels in periodontally affected patients versus either controls or periodontally treated patients, the level of evidence appears still limited to draw firm conclusions (PROSPERO CRD42020222681)
- …
