1,721,244 research outputs found

    Aortic regurgitation in athletes. Pieces of the puzzle we have so far omitted

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    The prevalence of valvular heart disease (VHD) rises with age, reaching 11.7% in individuals older than 75 years.1 In young individuals, VHD is usually related to the presence of a congenital valve abnormality, as bicuspid aortic valve (BAV) or mitral valve prolapse. This is also the case for athletes, where in the presence of these abnormalities few restrictions exist in eligibility for competitive sports participation, even if a strict follow-up would be desirable. BAV is the most common congenital valve abnormality (1%) found in the general population and in athletes. BAV is more prevalent in males and it can lead to aortic regurgitation (AR), aortic stenosis and/or aortic root dilation. At present, no definitive studies have proved that intensive sports participation could worsen the progression of BAV and limited data are available on athletes

    Regulation of calcium handling by autophagy. A a novel mechanism limiting cardiac hypertrophy and dysfunction?

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    Despite the increasing strategies to prevent and manage heart failure, this condition still has a high mortality and morbidity rate. Therefore, the identification of new therapeutic targets to treat this disease is urgently needed

    A surprising link with unexplained infertility: a possible Covid-19 paradox?

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    Unexplained infertility represents about 22–28 percent of infertility causes.The diagnosis is based on the exclusion of common causes using standard fertility investigation. Over the years, the causes of unexplained infertility or subfertility have been identified in pre-existing associated pathologies, such as alterations of the immune system, thyroid dysfunctions, and coagulopathies.Studies regarding the influence of psychological factors on the development of infertility highlighted that spontaneous pregnancies following adoption or the decision to remain childless are absolute exceptions. The link between stress and infertility in humans is still unclear. For many women, the effect of infertility and the subsequent medical therapy represents a considerable emotional stress
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