1,721,056 research outputs found
Clinical and hemodynamic performance of the ACURATE neo bioprosthesis: Looking far and beyond randomized trials
No full textComparison and integration of tactical path planning approaches for Urban Air Mobility
No full textThis paper develops several tactical path planning strategies specifically tailored for urban air mobility. The developed strategies not only account for obstacles and traffic, but also consider other relevant constraints to ensure a safe flight in urban scenarios such as risk and weather information and vehicle specifics and limitations (maximum altitude, flight path angle and endurance). In addition, the problem of ensuring reliable navigation performance is taken into account at planning level. Three tactical strategies are accounted for, which either update the time history on the trajectory or spatially modify the three-dimensional path by acting at local or global level. The three approaches are compared in the results to assess their performance as a function of the conflict geometry
Comparison of Investigator-Reported and Clinical Event Committee-Adjudicated Outcome Events in GLASSY
Full text linkBackground: Event adjudication by a clinical event committee (CEC) provides a standardized, independent outcome assessment. However, the added value of CEC to investigators reporting remains debated. GLASSY (GLOBAL LEADERS Adjudication Sub-Study) implemented, in a subset of the open-label, investigator-reported (IR) GLOBAL LEADERS trial, an independent adjudication process of reported and unreported potential outcome events (triggers). We describe metrics of GLASSY feasibility and efficiency, diagnostic accuracy of IR events, and their concordance with corresponding CEC-adjudicated events. Methods: We report the proportion of myocardial infarction, bleeding, stroke, and stent thrombosis triggers with sufficient evidence for assessment (feasibility) that were adjudicated as outcome events (efficiency), stratified by source (IR or non-IR). Using CEC-adjudicated events as criterion standard, we describe sensitivity, specificity, positive and negative predictive value, and global diagnostic accuracy of IR events. Using Gwet AC coefficient, we examine the concordance between IR- and corresponding CEC-adjudicated triggers. There was sufficient evidence for assessment for 2592 (98.3%) of 2636 triggers. Results: Overall, the adjudicated end point-to-trigger ratio was high and similar between IR- (88%) and non-IR-reported (87%) triggers. The global diagnostic accuracy and concordance between IR-reported and CEC-adjudicated outcome events was 0.70 (95% CI, 0.65-0.74) and 0.54 (95% CI, 0.45-0.62), respectively, for myocardial infarction; 0.77 (95% CI, 0.75-0.79) and 0.71 (95% CI, 0.68-0.74) for bleeding; 0.70 (95% CI, 0.62-0.79) and 0.59 (95% CI, 0.43-0.74) for stroke; 0.59 (95% CI, 0.52-0.66) and 0.39 (95% CI, 0.25-0.53) for stent thrombosis. For IR bleedings, the concordance with the CEC on type of events was generally weak. Conclusions: Implementing CEC adjudication in a pragmatic open-label trial with IR events is feasible and efficient. Our findings of modest global diagnostic accuracy for IR events and generally weak concordance between investigators and CEC support the role for CEC adjudication in such settings. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03231059
Peripheral Drug-Eluting Technology.
No full textAbstract
This article reviews current knowledge and applications of drug-eluting devices in the treatment of peripheral arterial disease. The authors briefly report on the performance of plain old balloon angioplasty and bare metal stents in femoro-popliteal and below-the-knee lesions. This article explains the rationale behind the development of drug-eluting devices and describes the main technical features of currently available drug-eluting stents and drug-coated balloons. Dedicated sections discuss the results of trials investigating the potential benefits of these devices used in femoro-popliteal and infra-popliteal arterial vascular beds. Finally, ongoing studies and potential novel applications of drug-eluting technologies in other vascular beds are mentioned
Contemporary use and results of intra-aortic balloon pump counterpulsation.
No full textMinerva Cardioangiologica
Volume 64, Issue 1, February 2016, Pages 84-91
Contemporary use and results of intra-aortic balloon pump counterpulsation (Review)
Gargiulo, G., Stabile, E., Perrino, C., Scudiero, F., Scudiero, L., Schiattarella, G.G., Franzone, A., Sannino, A., Giugliano, G., Trimarco, B., Esposito, G.
Department of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini 5, Naples, Italy
View references (48)
Abstract
Intra-aortic balloon pump (IABP) counterpulsation is the most widely used form of left ventricular mechanical support today, with more than 160,000 patients worldwide receiving this therapy annually. Currently, IABP support is indicated in patients with acute left ventricular systolic failure and cardiogenic shock whose management remains particularly complex and still today characterized by high mortality rates. While the available clinical practice guidelines support the indication to IABP placement in acute myocardial infarction (MI) with cardiogenic shock, recent clinical studies have questioned the benefits of IABP in these clinical settings. However, the rate of complications associated to IABP use is high and therefore the eventual IABP benefits must be weighed over the disadvantages. IABP still represents a very important mechanical support, however recent scientific evidences have challenged the value of its use, thus, it will be absolutely necessary to confirm these findings in a definitive RCT. This review will describe the role of IABP in the modern clinical practice
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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