1,085 research outputs found

    A global initiative to deliver precision health in diabetes

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    A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.</p

    DS_10.1177_0022034519897910 – Supplemental material for Heritability of Caries Scores, Trajectories, and Disease Subtypes

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    Supplemental material, DS_10.1177_0022034519897910 for Heritability of Caries Scores, Trajectories, and Disease Subtypes by S. Haworth, A. Esberg, P. Lif Holgerson, R. Kuja-Halkola, N.J. Timpson, P.K.E. Magnusson, P.W. Franks and I. Johansson in Journal of Dental Research</p

    Author Correction:A cattle graph genome incorporating global breed diversity

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    The original version of this Article omitted from the author list the 12th and 13th authors Dennis Muhanguzi and Wilson Amanyire, who are from the ‘School of Biosecurity, Biotechnology and Laboratory Sciences (SBLS), College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O Box 7062, Kampala, Uganda’. Consequently, the final sentence of the Author Contributions incorrectly read ‘D.W., P.T., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been replaced with ‘D.W., P.T., W.A., D.M., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been corrected in both the PDF and HTML versions of the Article

    Three years of Extreme Physiology &amp; Medicine

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    © 2015 Grocott and Montgomery. This article is distributed under the terms of the Creative Commons Attribution 4.0 Interna‑ tional License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Com‑ mons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecom‑ mons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

    Taxonomy and phylogeny of the genus Mycosphaerella and its anamorphs

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    Historically plant pathogenic species of Mycosphaerella have been regarded as host-specific, though this hypothesys has proven difficult to test largely due to the inavailability of fungal cultures. During the course of the past 20 years a concerted effort has been made to collect these fungi, and devise methods to cultivate them. Based on subsequent DNA sequence analyses the majority of these species were revealed to be host-specific, though some were not, suggesting that no general rule can be applied. Furthermore, analysis of recent molecular data revealed Mycosphaerella to be poly- and paraphyletic. Teleomorph morphology was shown to be too narrowly defined in some cases, and again too widely in others. Mycosphaerella and Teratosphaeria as presently circumscribed represent numerous different genera, many of which can be recognised based on the morphology of their 30 odd associated anamorph genera. Although Mycosphaerella is generally accepted to represent one of the largest genera of ascomycetous fungi, these data suggest that this is incorrect, and that Mycosphaerella should be restricted to taxa linked to Ramularia anamorphs. Furthermore, other anamorph form genera with Mycosphaerella-like teleomorphs appear to represent genera in their own right

    Advancing the roll-out of energy networks by embedding cost differentiation in modeling approaches which minimize assessed construction costs

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    This thesis aims to be a contribution to the roll-out of new energy networks by presenting and discussing ways to minimize assessed construction costs associated with these networks. It does this by providing an extension of already existing methods to estimate building costs.Energy and IndustryTechnology, Policy and Managemen

    Assessing the Maturity of Public Construction Client Organisations

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    The construction sector is changing, and commissioning organisations have to rethink the way they approach the market. This is especially important for client organisations operating in the public domain, because of their role as change agent in the sector and their social responsibilities. The ‘Public Commissioning Maturity Model’ (PCMM), first presented in 2014, was created to raise awareness amount construction clients’ organisations to the range and width of their commissioning task. It provides a means to elicit discussion on the current and desired state of the organisation’s competences, thereby supporting these organisations in further professionalization. As a result of sixworkshop-based discussion sessions and five panel discussions, the value of the model was determined. In this paper, the validation path of the model in practice is described. The findings resulted in changes to improve the usability of the model for the construction sector, as well as alterations to increase the understanding of the model for workshop participants. Adjustments regarding stylistic issues and elements in the maturity model and supporting materials were also made. Applying the PCMM has proven to enableassessment of the current and desired organisational performance on different aspects of public commissioning by eliciting discussion and raising awareness. It is however not constituted for numerical ranking, sector-wide monitoring or benchmarking purposes, while these needs also exist among client organisations. Furthermore, it was found that the model is less suitable for organisations in the middle of a comprehensive change process.Public Commissionin

    Safeguarding public values by project-based construction clients: Leads for future research

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    In an environment with large interdependencies like the construction industry, projectbased public construction organisations are challenged to seek for 'new' ways to safeguard public values and project outcomes. Public bodies increasingly depend on private parties to achieve public values. Hence, due to the character of their tasks, they remain socialpolitically responsible. In order to find leads for future research into safeguarding public values by construction clients, an explorative literature study was conducted. The fields of institutional logics, public organisation science and public value management were used to gain insights in relevant multi-level organisational concepts considering the meaning of public values in the daily practice of public clients. Hybridity was found as characteristic of public-private partnerships. Furthermore, the management of institutional complexity as a central task for public construction clients implies the importance of monitoring ambidexterity and accountability. Future research into the understanding of safeguarding public values at all levels of public construction clients must centralise these concepts in order to contribute to the professionalization of public construction clients.Public Commissionin

    Sustainable offices: Financially feasible to what extent?

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    Real Estate & HousingArchitectur
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