177,690 research outputs found
VUV-VIS optical characterization of Tetraphenyl-butadiene films on glass and specular reflector substrates from room to liquid Argon temperature
No full textThe use of efficient wavelength-shifters from the vacuum-ultraviolet to the photosensor’s
range of sensitivity is a key feature in detectors for Dark Matter search and neutrino
physics based on liquid argon scintillation detection. Thin film of Tetraphenyl-butadiene (TPB)
deposited onto the surface delimiting the active volume of the detector and/or onto the photosensor
optical window is the most common solution in current and planned experiments. Detector design
and response can be evaluated and correctly simulated only when the properties of the optical
system in use (TPB film + substrate) are fully understood. Characterization of the optical system
requires specific, sometimes sophisticated optical methodologies. In this paper the main features
of TPB coatings on different, commonly used substrates is reported, as a result of two independent
campaigns of measurements at the specialized optical metrology labs of ENEA and University of
Tor Vergata. Measured features include TPB emission spectra with lineshape and relative intensity
variation recorded as a function of the film thickness and for the first time down to LAr temperature,
as well as optical reflectance and transmittance spectra of the TPB coated substrates in the
wavelength range of the TPB emission
A case of eribulin-induced regression of liposarcoma of the left funiculus in a heavily pretreated patient
No full textWe report the case of a heavily pretreated male subject affected by left funiculus liposarcoma and successfully treated with eribulin mesylate. After three surgical interventions, radiotherapy on the lesion of the penile bulb for satellite nodules and an epirubicin + ifosfamide chemotherapy treatment for six cycles, eribulin was administered at the dose of 1.1 mg/m on days 1 and 8, every 3 weeks for a total of nine cycles. A significant reduction of the lesions was achieved after four cycles of therapy, with a good profile of tolerability. © 2020 Future Medicine Ltd
On the lifetime of the I-4(13/2) emitting level of the Er3+ ions in phosphate glasses
No full textThe decay time of the I-4(13/2) --> I-4(15/2) transition of Er3+ ions in phosphate glasses has been measured through a variable frequency of the pump beam intensity. It has been found that the decay times depend upon temperature and upon the presence of Yb codoping of host glass. The room temperature decay time increases from 5 to 8ms in presence of Yb codoping, but the longer decay time seems to be independent of the relative amount of Er and Yb. The decay times increase at low temperature, where, however, careful control of the sample temperature heated by the pump beam has to be performed. Mechanism of radiative and non-radiative decays are briefly described
Popolazione e dinamiche demografiche nella valle dell’Ombrone pistoiese (secc. XIII-XIX)
No full textTemperature dependence of the line shapes of two-photon excited transitions in KMgF3 : Eu2+
No full textThe two-photon excitation line shapes of f-f transitions of Eu2+ in KMgF3 have been investigated as a function of temperature. Results for several transition lines of the P-6(J) and D-6(J) multiplets are presented in this work. The two-photon excited transitions appear as zero-phonon lines with a Lorentzian profile whose peak energy is shifted from the zero temperature position. The observed temperature dependence of the zero-phonon line shapes is ascribed to the elastic scattering of the electronic transitions among vibrational states via anharmonic coupling to a phonon mode of the lattice heat-bath. In those components of 4f(7) multiplets whose energies are not resonant with the 4f(6)5d broad excited state, a direct proportionality to the phonon occupation number of the coupled mode is found for the line-shapes and peak-positions temperature dependences
Epirubicin alone or Epirubicin + ifosfamide as adjuvant chemotherapy in soft tissue sarcomas
No full textWeekly docetaxel and epirubicin in treatment of advanced hormone-refractory prostate cancer.
No full textOBJECTIVES:
To evaluate the efficacy and safety of a new regimen that combines weekly docetaxel and weekly epirubicin for the treatment of advanced hormone-refractory prostate cancer.
METHODS:
Docetaxel 30 mg/m2 and epirubicin 30 mg/m2 were intravenously administered on a weekly basis, for a maximum of 24 cycles. The therapy was discontinued after the first 12 cycles in the patients who responded or had stable disease and was resumed as soon as any signs of progression were noted.
RESULTS:
Of the 38 evaluable patients, 26 achieved a confirmed greater than 50% decrease in prostate-specific antigen level (68.4%, 95% confidence interval [CI] 51.2% to 82.0%). The median response duration was 8.8 months (95% CI 6.2 to 11.8), and the median time to progression was 7.4 months (95% CI 5.6 to 9.6). Pain was rapidly reduced in 24 (72.7%, 95% CI 54.2 to 86.7) of the 33 patients who were symptomatic at baseline. Of the 38 patients, 21 resumed therapy after the planned interruption; of these, 3 had a prostate-specific antigen response (14.2%) and 12 had stable disease (57.1%). The regimen was well tolerated. Grade 3 neutropenia occurred in 15.7% of the patients, grade 3 anemia in 13.1%, and grade 3 thrombocytopenia in 7.8%.
CONCLUSIONS:
The results of this study have suggested the feasibility and tolerability of the combination of weekly docetaxel and weekly epirubicin, which led to a rapid and long-lasting decrease in prostate-specific antigen levels and a palliative response in patients with advanced hormone-refractory prostate cancer. © 2007 Elsevier Inc. All rights reserved
The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer
No full textAdvanced hormone-refractory prostate cancer (HRPC) is characterized by prevalently osteoblastic bone metastases which are what mostly affect these patients' quality of life and make the assessment of response to treatment particularly difficult by commonly used criteria. HRPC cannot be cured by any available therapeutic option, and chemotherapy has to be still considered as a palliative treatment. The anthracyclines doxorubicin (Dox) and epirubicin (Epi), alone or in combination with other agents, have been extensively used in the treatment of HRPC, but controversial results have been reported. The majority of reviewed studies reported a pain reduction in >50% of patients receiving Dox or Epi, suggesting a substantial palliative effect by their use in metastatic HRPC. The weekly schedule of anthracyclines seemed to achieve similar results to the 3-weekly schedule but with a better toxicity profile. Although the toxic adverse effects were usually manageable when anthracyclines were combined with other agents, toxicity was severe by a number of aggressive regimens. Docetaxel is today approved for the treatment of HRPC, and must be considered the standard platform on which new agents may be combined. Given that HRPC includes a heterogeneous group of patients with variable rates of tumour growth, the combination of docetaxel with active agents such as anthracyclines may deserve further clinical investigation
Per-Pixel Forest Attribute Mapping and Error Estimation: The Google Earth Engine and R dataDriven Tool
No full textRemote sensing products are typically assessed using a single accuracy estimate for the entire map, despite significant variations in accuracy across different map areas or classes. Estimating per-pixel uncertainty is a major challenge for enhancing the usability and potential of remote sensing products. This paper introduces the dataDriven open access tool, a novel statistical design-based approach that specifically addresses this issue by estimating per-pixel uncertainty through a bootstrap resampling procedure. Leveraging Sentinel-2 remote sensing data as auxiliary information, the capabilities of the Google Earth Engine cloud computing platform, and the R programming language, dataDriven can be applied in any world region and variables of interest. In this study, the dataDriven tool was tested in the Rincine forest estate study area—eastern Tuscany, Italy—focusing on volume density as the variable of interest. The average volume density was 0.042, corresponding to 420 m3 per hectare. The estimated pixel errors ranged between 93 m3 and 979 m3 per hectare and were 285 m3 per hectare on average. The ability to produce error estimates for each pixel in the map is a novel aspect in the context of the current advances in remote sensing and forest monitoring and assessment. It constitutes a significant support in forest management applications and also a powerful communication tool since it informs users about areas where map estimates are unreliable, at the same time highlighting the areas where the information provided via the map is more trustworthy. In light of this, the dataDriven tool aims to support researchers and practitioners in the spatially exhaustive use of remote sensing-derived products and map validation
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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