116 research outputs found
Bortezomib-containing multimodality treatment for antibody-mediated rejection with anti-HLA and anti-AT1R antibodies after kidney transplantation
No full textFor decades, the human leukocyte antigen (HLA) complex
has been considered the primary target of antibody-mediated
rejection (AMR), and treatment strategies have mainly focused
on anti-HLA antibodies. Recently, other antibodies potentially
causing organ damage and loss have been discovered.
Conclusive evidence on treatment options for these subtypes
of AMR is still lacking. After an experience previously
reported in this journal,1 we describe a case of late-onset AMR,
with mixed anti-HLA and anti-angiotensin II type 1 receptor
(AT1R) antibodies, that was successfully treated with a multimodal
approach, including the use of the proteasome inhibitor
bortezomib
An original technique to reduce the haemorrhage rate of stapled haemorrhoidopexy in day surgery.
No full textA Multi-objective Design Approach to Include Material, Manufacturing and Assembly Costs in the Early Design Phase
No full textAbstractConceptual design is a crucial activity in the product development process. The design freedom must consider a trade-off analysis among several aspects such as assembly, manufacturing, and costs. The goal of this approach is to define a multi-objective design approach for the determination of feasible design options. The approach is grounded on the concept of functional basis for the analysis of product modules and the theory of Multi Criteria Decision Making (MCDM) approach for the assessment of the best design option. A complex product (tool-holder carousel of a machine tool) is used as a case study to validate the approach
Laparoscopic wedge resection of parenchymal organs: our experience.
No full textIntroduction: Laparoscopic wedge resection (LWR) of parenchymal organs (PO) can be performed safely in many instances. Bleeding and or postoperative bile leaks are the most common complications following these operations. Methods: Between June 2006 and June 2007, 19 LWR of liver and of kidney were performed (11 males and 8 females). Mean age 55.7 yrs (range 31–68). They were 13 hepatic metastases and 6 renal cell carcinomas. Ultracision® and Ligasure® devices were used respectively in 15 and 4 cases. Hemostasis was always completed by using a combination of fibrin glue, gelatine matrix thrombin or fibrin sponge. Results: All procedure were completed laparoscopically, mean operative time 115 minutes (range 75–190), mean blood loss 250 ml (50–400), mean postoperative stay 5 days (3–8). Discussion: LWR of PO using modern surgical instruments, ultrasonic or radiofrequency devices, with biologic hemostatic and sealant agent, is technically simple and safety and permits to decrease intra and postoperative complications. Indications are limited to resection of subglissonian lesions of II-III-IV-V-VI hepatic segments and of cortical renal nodules without involvement of pelvis
Found the needle in the haystack! The case of a fishbone causing vasovagal syncopes and abdominal pain: a case report
No full textForeign body ingestion is a very common reason for access to the Emergency Department and in most cases, it doesn't cause symptoms; in case of fishbones, intestinal perforation is rare but possible. In this report, besides the typical picture of bowel perforation, we found atypical symptoms due to the specific location.
We present a case of a 70-year-old man who presented to the Emergency Department complaining abdominal pain and several syncopes; a CT scan of the abdomen revealed the presence of a foreign body in the pyloric area, which was removed by surgical intervention and resulted to be a fishbone. Both abdominal and neurological symptoms disappeared.
Results and conclusion
We suppose that the specific location of fishbone, in the area when the pyloric branches of left vagus nerve run, can explain both the abdominal symptoms and the vasovagal syncope, through a sympathetic inhibition mechanism: Emergency physicians and emergency surgeons must be aware when dealing with symptoms apparently discordant that could be attributable to one common factor
La chirurgia attraverso gli orifici naturali, NOTES, colecistectomia trans vaginale, nostra esperienza.
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