95 research outputs found

    Corrigendum to “Esophageal motility disorders among elderly patients: An international multicenter study” [Digestive and Liver Disease 57 (2025) 1615-1621]

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    The authors regret that the name of author Francesco Calabrese was spelt incorrectly. The correct spelling appears above and the online article has been amended. The authors would like to apologise for any inconvenience caused

    Erratum to: Design of a Lentiviral Vector for the Inducible Expression of MYC: A New Strategy for Construction Approach

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    Unfortunately in the original publication, the affiliations associated with the author Francesco Paolo Fiorentino were incomplete. Also the order of affiliations should be changed. The corrected list of affiliations is given in this erratum. © 2017, Springer Science+Business Media New York

    Rates and Causes of Death in Chiradzulu District, Malawi, 2008: A Key Informant Study

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    In September 2008, we measured all-cause mortality in Chiradzulu District, Malawi (population 291 000) over a 60-day retrospective period, using capture-recapture analysis of three lists of deaths provided by (i) key community informants, (ii) graveyard officials and (iii) health system sources. Estimated crude and under-5-year mortality rates were 18.6 (95% CI 13.9-24.5) and 30.6 (95% CI 17.5-59.9) deaths per 1000 person-years. We also classified causes of death through verbal autopsy interviews on 50 deaths over the previous 40 days. Half of deaths were attributable to infection, and half of deaths among children aged under 5 were attributable to neonatal causes. HIV/AIDS was the leading cause of death (16.6%), with a cause-attributable mortality rate of 1.8 (0.4-3.6) deaths per 1000 person-years

    Colonna's crossing: the hypnerotomachia poliphili as a culminating experience

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    The Hypnerotomachia Poliphili (Strife of Poliphilo) is a complex relic of an era in transition. The author, Francesco Colonna, wrote this text sometime between 1467 and 1499 amid changing ideals for both the religious and the scholarly worlds. The new age of Renaissance Humanism was butting up against more stoic medieval traditions. Authors struggled with those traditions as academia shifted its perceptions on approved scholarly language, reverting back to classical Latin. Colonna's work speaks to all the issues present in his world. The Hypnerotomachia dives deep into Neoplatonic and alchemical philosophies, explores Love through medieval literary devices, imitates Antiquity in an homage to Humanist ideals, and plays with language in a most spectacular manner. The work is complex and difficult and often dismissed for its excessiveness. But as soon as the first page is turned one can see that it is undeniably worthy of intense academic investigation.Includes bibliographical references (leaves 129-147)California State University, Northridge. Department of English

    Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

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    OBJECTIVE: To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs). METHODS: We calculated direct costs (based on experience from Ethiopia and southern Sudan) and effectiveness (in terms of reduced over-treatment) of a free, decentralised treatment programme using artesunate plus amodiaquine (AS + AQ) or artemether-lumefantrine (ART-LUM) in a Plasmodium falciparum epidemic. Our main cost-effectiveness measure was the incremental cost per false positive treatment averted by RDTs. RESULTS: As malaria prevalence increases, the difference in cost between presumptive and RDT-based treatment rises. The threshold prevalence above which the RDT-based strategy becomes more expensive is 21% in the AS + AQ scenario and 55% in the ART-LUM scenario, but these thresholds increase to 58 and 70%, respectively, if the financing body tolerates an incremental cost of 1 euro per false positive averted. However, even at a high (90%) prevalence of malaria consistent with an epidemic peak, an RDT-based strategy would only cost moderately more than the presumptive strategy: +29.9% in the AS + AQ scenario and +19.4% in the ART-LUM scenario. The treatment comparison is insensitive to the age and pregnancy distribution of febrile cases, but is strongly affected by variation in non-biomedical costs. If their unit price were halved, RDTs would be more cost-effective at a malaria prevalence up to 45% in case of AS + AQ treatment and at a prevalence up to 68% in case of ART-LUM treatment. CONCLUSION: In most epidemic prevalence scenarios, RDTs would considerably reduce over-treatment for only a moderate increase in costs over presumptive diagnosis. A substantial decrease in RDT unit price would greatly increase their cost-effectiveness, and should thus be advocated. A tolerated incremental cost of 1 euro is probably justified given overall public health and financial benefits. The RDTs should be considered for malaria epidemics if logistics and human resources allow
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