25 research outputs found
sj-docx-1-tab-10.1177_1759720X221080375 – Supplemental material for Pregnancy in juvenile idiopathic arthritis: maternal and foetal outcome, and impact on disease activity
No full textSupplemental material, sj-docx-1-tab-10.1177_1759720X221080375 for Pregnancy in juvenile idiopathic arthritis: maternal and foetal outcome, and impact on disease activity by Maria Gerosa, Cecilia Beatrice Chighizola, Francesca Pregnolato, Irene Pontikaki, Angela Flavia Luppino, Lorenza Maria Argolini, Laura Trespidi, Manuela Wally Ossola, Enrico M. Ferrazzi, Roberto Caporali and Rolando Cimaz in Therapeutic Advances in Musculoskeletal Disease</p
Antidepressants and benzodiazepines for panic disorder in adults
No full textA panic attack is a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. Panic disorder is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions. Amongst pharmacological agents, antidepressants and benzodiazepines are the mainstay of treatment for panic disorder. Different classes of antidepressants have been compared; and the British Association for Psychopharmacology, and National Institute for Health and Care Excellence (NICE) consider antidepressants (mainly selective serotonin reuptake inhibitors (SSRIs)) as the first-line treatment for panic disorder, due to their more favourable adverse effect profile over monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs). In addition to antidepressants, benzodiazepines are widely prescribed for the treatment of panic disorder
Toward a History of Ancient Realism: the case of Agatharchides
No full textreservedAgatarchide di Cnido (II sec. a. C.), nel trattato di contenuto geografico Sul mare eritreo, la nostra conoscenza del quale dipende da Fozio, Diodoro e Strabone, descrive dettagliatamente lo sfruttamento delle miniere d’oro in Nubia ad opera della corona tolemaica. Questa sezione descrittiva è preceduta da un’ampia trattazione teorica sul problema retorico di come si debba narrare in maniera appropriata il dolore degli altri. La tesi intende indagare il realismo di Agatarchide, alla luce della coeva riflessione teorico-letteraria. Essa si divide in due parti: nella prima si compie una ricognizione delle testimonianze sulla vita e l'opera di Agatarchide, nonché si traccia una breve genealogia del concetto di realismo in età moderna e una disamina della sua fortuna all'interno della filologia classica; nella seconda si prende in esame il realismo di Agatarchide tanto sul piano della forma, quanto su quello dei contenuti, ponendolo in costante raffronto con altre fonti di età classica ed ellenistica.Agatharchides of Cnidus (2nd century BC), in his geographical treatise On the Erythraean Sea - our knowledge of which is based on Photius, Diodorus and Strabo - describes in detail the exploitation of the gold mines of Nubia by the Ptolemaic kingdom. This descriptive section is preceded by a theoretical dissertation on the rhetorical problem of how a writer should properly recount the misfortunes of others. This dissertation examines the realism of Agatharchides in the light of contemporary literary criticism. It is divided into two parts: the first part collects the testimonies on the life and work of the author and analyses the fortune of the concept of realism in Classical Studies; the second part examines the realism of Agatharchides, both on the level of style and content, in constant comparison with other sources of the Classical and Hellenistic periods
Pregnancy in juvenile idiopathic arthritis: maternal and foetal outcome, and impact on disease activity
No full textObjective: This retrospective cohort study describes the modulation of disease activity during gestation and in the year following delivery as well as maternal and neonatal outcomes in a monocentric cohort of women with juvenile idiopathic arthritis (JIA).Methods: Disease activity was assessed using DAS28-CRP before conception and every 3 months during pregnancy and in the first year postpartum. The risk of complicated pregnancies was measured applying a generalized estimating equation model. Changes in disease activity during gestation and in the first year postpartum were assessed in a linear mixed model for repeated measures.Results: Thirty-one women (49 pregnancies) with persisting JIA and at least one conception were enrolled. Adjusted DAS28-CRP levels remained stable from preconception through the first trimester, but increased significantly in the second and decreased not significantly in the third. In the postpartum, adjusted disease activity peaked at 3 months after delivery, stabilized at 6 months to decrease at 1 year, although not significantly. Preconceptional DAS28-CRP and number of biological drugs predicted disease activity fluctuation during gestation. The number of biological drugs and the length of gestational exposure to biologics significantly predicted pregnancy morbidity. In particular, JIA women had a higher probability of preterm delivery compared with healthy and disease controls. Adjusted for breastfeeding and DAS28-CRP score in the third trimester, postconceptional exposure to biologics was inversely related with disease activity in the postpartum: the longer the patient continued treatment, the lower the probability of experiencing an adverse pregnancy outcome.Conclusion: These data offer novel insights on how treatment affects disease activity during pregnancy and postpartum as well as obstetric outcomes in women with JIA
Prenatal manifestation and management of a mother and child affected by spondyloperipheral dysplasia with a C-propeptide mutation in COL2A1: case report
No full textAbstract It is not unusual for patients with "rare" conditions, such as skeletal dysplasias, to remain undiagnosed until adulthood. In such cases, a pregnancy may unexpectedly reveal hidden problems and special needs. A 28 year old primigravida was referred to us at 17 weeks for counselling with an undiagnosed skeletal dysplasia with specific skeletal anomalies suggesting the collagen 2 disorder, spondyloperipheral dysplasia (SPD; MIM 156550). She was counselled about the probability of dominant inheritance and was offered a prenatal diagnosis by sonography. US examination at 17, 18 and 20 weeks revealed fetal macrocephaly, a narrow thorax, and shortening and bowing of long bones. The parents elected to continue the pregnancy. At birth the baby showed severe respiratory distress for four weeks which then resolved. Mutation analysis of both mother and child revealed a hitherto undescribed heterozygous nonsense mutation in the C-propeptide coding region of COL2A1 confirming the diagnosis of SPD while reinforcing the genotype-phenotype correlations between C-propeptide COL2A1 mutations and the SPD-Torrance spectrum. This case demonstrates the importance of a correct diagnosis even in adulthood, enabling individuals affected by rare conditions to be made aware about recurrence and pregnancy-associated risks, and potential complications in the newborn.</p
Eidmannella pallida
No full text<i>Eidmannella pallida</i> (Emerton, 1875) <p> <i>Nesticus pallidus</i> Emerton, 1875: 279, pl. 1, f. 22–27 (♁ ♀).</p> <p> <i>Microneta gigantea</i> Banks, 1892: 48, pl. 2, f. 52 (♀).</p> <p> <i>Nesticus cavicola</i> Banks, 1898a: 186 (♁ ♀).</p> <p>See the World Spider Catalog for the complete list of references.</p> <p> <b>Material examined.</b> <b>ITALY: Veneto Region:</b> 41♁, 13♀, Padova, Baone (DNPC); 4♁, 2♀, same locality (FBPC); 2♁, 3♀, same locality (MSNBG); 22♁, 4♀, Cinto Euganeo (DNPC); 3♁, 4♀, same locality (MSNBG); 10♁, 1♀ Rovolon (DNPC); 2♁, same locality (MSNBG); 1♀ Teolo (DNPC); 18♁, 3♀, Torreglia (DNPC); 10♁, 2♀, Vo’ (DNPC); 10♁, 1♀, same locality (MSNBG); 1♁, 1♀ Vicenza, Gambellara (DNPC); 1♁, same locality (MSNBG); 1; 5♁, 1♀ Montebello Vicentino (DNPC); 1♁, same locality (MSNBG), all in vineyard with pitfall traps, G. Trespidi & A. Turetta leg.; 1♁, 1♀ Val Liona, D. Nardi leg. (MSNBG); 19♁, 5♀, Venezia, Chioggia, wetland/field margin/crop field, pitfall traps, G. Barbieri leg. (MSNBG); <b>Friuli-Venezia Giulia Region:</b> 1♁, Udine, Muzzana del Turgnano, crop field, pitfall traps, F. Lami leg. (MSNBG); <b>Calabria Region:</b> 2♁, Cosenza, Rende (MSNBG); 5♁, Rossano (MSNBG), all in olive orchard, pitfall traps, P. Rizzo leg. Collecting dates and additional information on the examined Italian specimens are provided in Supplementary Materials, Table S2.</p> <p> <b>Diagnosis.</b> <i>Eidmannella pallida</i> can be easily distinguished from most Nesticidae by the small size and the pale coloration lacking any dorsal pattern (Fig. 2E, F). Males can be further recognized by the following combinations of characters: paracymbium with only 2 short distal apophyses (Di-I, II) and a short ventral apophysis (Va), a trapezoidal radical apophysis strongly protruding from the radix, a thick threadlike embolus gradually thinning in the last trait, a strongly-developed and prominent median process of conductor (Cm) wrapped around the tip of embolus, and a strongly reduced and barely visible retrolateral process (Cr) (vs. different shape and level of development of processes in other nesticids) (Figs. 2A–D, 3A–E). Females can be distinguished by the following combination of diagnostic characters of epigynum and vulva: a short and wide scapus (Sc) partially covered by a triangular median plate (Mp), anterior diverticula clearly visible by transparency in the frontal part of epigynum, and large ventral pockets partially covering the copulatory ducts and spermathecae (vs. different shape of epigynum and vulva in other Nesticidae) (Fig. 2G, H). For the separation of <i>E. pallida</i> from other congeneric <i>Eidmannella</i> species see Gertsch (1984: 55).</p> <p> <b>Redescription</b> (based on specimens from North Italy).</p> <p> <b>Male.</b> Habitus as in Fig. 2E. Total length. 2.57, Prosoma 1.22 long, 1.01 wide. Carapace rounded, uniformly yellowish with inconspicuous striae. Cervical groove slightly visible, with a light dark margin, fovea indistinct. Eight eyes all well developed, AME the smallest. Eyes measurements: AME = 0.06, ALE = 0.08, PME = 0.09, PLE = 0.09, AME–ALE = 0.05, ALE–PLE = 0.06. Chelicerae, labium, maxillae and sternum of same yellowish color as carapace. Legs uniformly yellowish. Leg formula. I, IV, II, III. Legs measurements: I 5.74 (1.54, 0.48, 1.50, 1.49, 0.74), II 4.35 (1.24, 0.40, 1.07, 0.99, 0.65), III 3.51 (1.04, 0.35, 0.72, 0.85, 0.55), IV 5.03 (1.45, 0.43, 1.22, 1.28, 0.65). Opisthosoma lacking any clear pattern, uniformly greyish with sparce slightly lighter marks on the dorsal and lateral side.</p> <p>Male palp as in Figs. 2A–D, 3A–E. Cymbium ovoid with 2–3 thicker, barbed hairs on the antero-prolateral margin (Fig. 2C, D). Paracymbium with 2 short and blunt, distal apophyses (Di-I, II) and 1 longer and sharper ventral apophysis (Va) (Figs. 2A, B, D; 3A, E). Embolus (E) with a clockwise course, thread-like and long, thick for 2/3 of its length, narrowing in the last trait. Origin of embolus positioned at approx. 6:00 o’clock on radix (Rx). Radical apophysis (Ra) trapezoidal, strongly protruding prolaterally from the radix. Conductor with 3 distinct processes. Median process of conductor (Cm) strongly developed and strongly protruding antero-prolaterally, wrapped around tip of embolus and ending with a sharp tip. Prolateral process (Cp) wide and flat, headed counterclockwise around embolus. Retrolateral process (Cr) small and thick, similar to a small bulge. (Figs. 2 A−C, 3A–D).</p> <p> <b>Female.</b> Habitus as in Fig. 2F. Total length 2.97, Prosoma 1.28 long, 1.11 wide. Carapace piriform. Eyes measurements: AME = 0.06, ALE = 0.09, PME = 0.09, PLE = 0.09, AME–ALE = 0.04, ALE–PLE = 0.06. Legs measurements: I 5.84 (1.69, 0.51, 1.46, 1.45, 0.73), II 4.47 (1.33, 0.46, 1.02, 1.06, 0.60), III 3.45 (1.03, 0.43, 0.68, 0.82, 0.49), IV 5.12 (1.58, 0.41, 1.26, 1.25, 0.62). Coloration and other details as in male.</p> <p>Epigynum and vulva as in Fig. 2G, H. Scapus (Sc) short and wide, elongated laterally, ending with a flat posterior margin. Median plate (Mp) flat, partially covering scapus, ending with a triangular posterior margin (Fig. 2G). Copulatory opening (Co) at the lateral sides of scapus. Internal ducts visible through the transparent tegument of median plate. Ventral pockets (Vp) wide, balloon-like, with a wrinkled surface. Anterior diverticula of ventral pockets (Ad), short, comma-like, converging to each other at the center. Copulatory ducts (Cd) S-shaped, headed first internally then anteriorly, gradually converging at the center. Spermathecae (S) round, separated from each other by approximately their diameter (Fig. 2H).</p> <p> <b>Remarks on variation.</b> Male (based on 4 specimens): total length: 2.25–2.57, prosoma length: 1.09–1.22, prosoma width: 0.99–1.01. Female (based on 4 specimens): total length: 2.96–2.98, prosoma length: 1.25–1.28; prosoma width: female: 1.09–1.11.</p> <p> <i>Eidmannella pallida</i> exhibits a wide range of different phenotypes among different populations with high variability in the coloration and pigmentation of the opisthosoma and the degree of eye atrophy (Gertsch 1984). Moreover, minor differences in the morphology of genitalia also exist as can be observed in published scientific drawings of this species, sometimes even among the same author (Dumitrescu 1973). It is currently unclear if such differences can be considered as intraspecific variation of a single morphologically plastic species, or if these phenotypes represent a complex of closely related but distinct species.</p>Published as part of <i>Nardi, Davide, Pantini, Paolo, Rizzo, Pierluigi, Trespidi, Giacomo, Turetta, Alessandra, Barbieri, Giacomo & Ballarin, Francesco, 2023, A comprehensive update on the morphology and distribution of the invasive scaffold-web spider Eidmannella pallida (Araneae, Nesticidae) with a focus on new records from Italy, pp. 221-264 in Zootaxa 5351 (2)</i> on pages 231-234, DOI: 10.11646/zootaxa.5351.2.3, <a href="http://zenodo.org/record/8391458">http://zenodo.org/record/8391458</a>
Systemic vasculitis and pregnancy: a multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies
No full textOBJECTIVE: Systemic vasculitis (SV) are uncommon diseases that rarely affect women during their reproductive age; little data, mainly retrospective, is available on this topic. The aim of our study was to evaluate maternal/neonatal outcome and disease course before, during and after pregnancy.
METHODS: Sixty-five pregnancies in 50 women with SV were followed by a multispecialistic team in 8 institutions between 1995 and 2014. Clinical data on pregnancy, 1year before and 1year after delivery was retrospectively collected. The rate of pregnancy complications was compared to that of a General Obstetric Population (GOP) of 3939 women.
RESULTS: In 2 patients the diagnosis of SV was done during pregnancy; 59 out of the remaining 63 started when maternal disease was quiescent. We recorded 56 deliveries with 59 live births, 8 miscarriages and 1 fetal death. In SV, preterm, particularly early preterm (<34weeks) deliveries and cesarean sections appeared significantly more frequent than in GOP (11.3% vs 5.0%, p=0.049 and 48.2% vs 31.0%, p=0.009). Vasculitis-related complications occurred in 23 pregnancies (35.4%), with 5 severe events (7.7%) including 3 cases of transient ischemic attack (TIA). Data about the post-partum period were available for 56 pregnancies: 12 flares (21.4%) occurred, with 1 severe event (1.8%).
CONCLUSION: SV patients can have successful pregnancies (especially during a disease remission phase) despite an increased rate of preterm delivery. Severe flares were limited, but the occurrence of 3 TIA suggests that particular attention should be given to possible thrombotic complications in SV patients during pregnancy and puerperium
