218 research outputs found
Ripensare i nuovi luoghi della cultura: strategie ibride di recupero e riuso culturale. Il progetto di rigenerazione urbana degli ex magazzini della stazione ferroviaria di Noto
No full textThis paper addresses the topic of architectural, social and economic regeneration of urban areas under-
going transformation or decay, from a cultural development perspective. The paper focuses on the employment
of art and culture as tools for the urban regeneration, describing the reuse project of the former warehouses of the
railway station of Noto, developed as part of an innovative capacity building training course in the context of the
PNRR. This contribution aims, therefore, to communicate the urban culture of the city of Noto, combining in the
discussion as well as in the project, architecture, guidelines for the reuse of architectural heritage, environmental
design and cultural management strategies. The redevelopment project plans to offer to the city of Noto hybrid
spaces of confrontation, exchange and residence, replacing the dissipative model of soil resources, quality and
opportunity, with a new value-generating paradigm of quality and local identity
Inclusive innovation and the role of partnerships: The case of Semi di Libertà
No full textPurpose – This chapter aims to understand how partnerships and networks can aid the development and growth of organizations whose goal is to foster social inclusion along the agro-food supply chain, with particular reference to the social entrepreneurship sector. Methodology/approach – The chapter draws on a framework proposed by Newth and Woods (2014) to identify the main drivers of resistance to the development of social entrepreneurship. The empirical evidence is based on a single case, involving an Italian social enterprise, Semi di Liberta`, which produces high-quality artisan beer. Case material included an analysis of organization documents and interviews with key actors. Findings – The case study shows how Semi di Liberta` faced different types of resistance, related to formal and informal institutions and market drivers, and leveraged partnerships with other actors in the ecosystem. Some of these partnerships were planned a priori to overcome specific problems (e.g., the Prison’s Authority, Mastri Birrai). Other partnerships were developed “by chance” (e.g., “peer” associations) but turned out to be particularly important to deal with the above resistances. Research limitations/implications – The case study methodology prevents the authors from generalizing too far past the obtained results. However, key elements from the case, such as the relevance of “spontaneous” partnerships and those with “peer” organizations, could be taken into account for similar initiatives in different contexts. Originality/value – Recent literature has highlighted the relevance of partnerships in scaling social enterprises but has not explored the dynamics whereby these partnerships are created and developed. This chapter provides some preliminary evidence of how partnerships can be used to overcome the resistance limiting the growth of social entrepreneurship and the sustainability of socially inclusive initiatives
Rapid screening of drugs of abuse and their metabolites by gas chromatography/mass spectrometry: application to urinalysis
No full textThis paper describes a rapid gas chromatographic/mass spectrometric (GC/MS) screening method
for the detection of drugs of abuse and/or their metabolites in urine. Synthetic stimulants, opiates,
cocaine metabolites, cannabinoids—and specifically the acid metabolite of tetrahydrocannabinol
(THC-COOH)—can be simultaneously extracted by a single liquid/liquid separation step, at alkaline
pH, and assayed as trimethylsilyl derivatives by GC/MS in SIM (selected ion monitoring)
mode. All the analytes show a good linearity (R2>0.99 for most of the considered substances) in
the range 25–1000 ng/mL, with a good reproducibility of both the retention times (CV% <0.7) and
the relative abundances of the characteristic diagnostic ions (CV% <13). The limit of detection
(LOD) of the method is 25 ng/mL of target compound in human urine for most of the substances
investigated, 3 ng/mL for THC-COOH, and 10 ng/mL for norbuprenorphine. Validation of the
method allows its application to different fields of forensic analytical toxicology, including antidoping
analysi
Profilo igienico di chiocciole (Helix spp.) provenienti da due allevamenti italiani
No full textNegli ultimi anni in Italia, con l’incremento del consumo di chioc-ciole, è cresciuto il numero di allevamenti e questi prodotti di origi-ne animale non convenzionali hanno conquistato la grande distri-buzione organizzata, che esige determinati standard qualitativi. Lanormativa vigente in materia di igiene degli alimenti non è specificaed esaustiva riguardo alle chiocciole terrestri ed anche i dati pre-senti in letteratura sono piuttosto scarsi. Scopo del presente lavoroè analizzare dal punto di vista microbiologico le carni di chioccioladella specie Helix aspersadi due allevamenti, differenti per tipo elocalizzazione geografica, uno di tipo sperimentale senza terrainSicilia e uno tradizionale all’aperto in Toscana. Le analisi microbio-logiche, finalizzate alla determinazione dei principali parametri igie-nici e di sicurezza alimentare, sono state effettuate su tre campionidi circa 1 kg provenienti da tre lotti di chiocciole pronte per la com-mercializzazione, per ciascun allevamento. Non sono state riscon-trate differenze statisticamente significative tra i due tipi di alleva-mento, anche se i valori della carica batterica totale e delleEnterobacteriaceaedelle chiocciole provenienti dall’allevamentosenza terraerano più alti di quelli rilevati nell’allevamento tradizio-nale (6,91±0,75 log UFC/g vs5,81±1,07 log UFC/g e 5,66±0,88log UFC/g vs4,30±1,14 log UFC/g); tali risultati sono in linea conquanto presente in letteratura (Parlapani et al., 2015). Gli stafilo-cocchi coagulasi-positivi presentavano in entrambi i casi valorimedi al di sotto di 3,5 log UFC/g. L’assenza dei patogeni presi inesame (Salmonellaspp., Clostridium perfringense Bacillus cereus)evidenzia un adeguato livello igienico del prodotto. La gestionerazionale dell’allevamento ed il controllo lungo tutta la filiera pos-sono quindi garantire la qualità di questi prodotti. Resta però lanecessità di colmare un vuoto normativo, prendendo nella dovutaconsiderazione il comparto delle chiocciole eduli
I luoghi che abiteremo.Rigenerazione urbana per l'innovazione culturale,a cura di Cantina Sperimentale Iblea
No full textIl progetto mira a trasformare il sito degli ex magazzini della Stazione ferroviaria di Noto, in porta di accesso alla città, spazio d’incontro tra i turisti, il territorio, le sue tradizioni e la comunità residente e, per quest’ultima, luogo di aggregazione e spazio per la quotidianità. L’area oggetto di riqualificazione si inserisce all’interno di un programma di incentivazione turistica come tappa di un più ampio itinerario culturale, prevedendo anche di rinnovare il rapporto tra la comunità residente e il territorio, proponendosi come spazio di cultura e socialità
Shallow-water sponge grounds along the Apulian coast (central Mediterranean Sea)
No full textSponge grounds are complex three-dimensional benthic habitats dominated by sponges. These sponge-dominated assemblages have been reported worldwide, from the intertidal zone to the deep sea. In shallow euphotic waters, dense sponge aggregations have been mainly found in tropical areas, and their presence is in some cases related to environmental degradation and coral decline. The Mediterranean Sea is globally recognised as a biodiversity hotspot, where light-exposed rocky reefs are typically dominated by photophilous algae. However, high local anthropogenic pressures, coupled with climate change, are leading to the reorganisation of benthic communities and the occurrence of regime shifts in several areas. Here we report the first description of unusual, shallow-water sponge grounds in Mediterranean light-exposed rocky reefs, in an area previously impacted by the destructive date-mussel fishery. These assemblages, found along the Apulian coast (central Mediterranean Sea), are now (2017) characterised by a mean coverage of sponges ranging between 3% and 33%, with maximum values up to 85%. Variation in the structure of assemblages and in the abundance of individual taxa between depths has been tested by multivariate and univariate techniques. The spatial characterisation has been complemented with the taxonomic analysis of the sponge assemblages, which resulted in the identification of 14 sponge taxa. These findings are compared with results of previous research in the same area and discussed with particular reference to the potential variables involved in sponge dominance and spatial distribution in the present system and elsewhere
Pensieri, sul calamus elegiaco
No full textFrancesca Favaro Pensieri, sul calamus elegiaco* Lo stagno sembra, più ancora che assopito, assetato. Strano a dirsi, in effetti, per una distesa d’acqua... Tuttavia, sulla superficie pressoché immobile, piatta e liscia, aleggia l’ombra di una mancanza, il sentore dell’attesa: come se l’acqua, davvero, avesse sete. Sete di luce, forse, sete di vento. Sete di una rivelazione. Tutt’intorno, le canne palustri mantengono una sorta di virtuoso riserbo e restano ferme, nell’aria calda dell’es..
Method development for the identification of methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine and their main metabolites in blood and hair and forensic application
No full textThe constant increase of new psychoactive substances, often available on the illicit drug market as 'research chemicals', poses a concern for public health and a significant analytical and legislative challenge. Β-keto-arylcyclohexamines represent a class of dissociative anesthetics recently introduced on the market of New Psychoactive Substances (NPS). There is still a lack of information about the pharmacological activity of many of such substances, usually depending on the potential chemical modifications introduced to circumvent the law. Furthermore, their intake may not be fully intentional, since consumers do not always have knowledge of the content of online purchases.
The present study describes the characterization by liquid chromatography-high resolution mass spectrometry (LC-HRMS), using a benchtop Orbitrap instrument, of the novel ketamine analogues methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine, found in the post-mortem blood and hair samples from a forensic case of suicide by fall from height, and of some of their metabolites. This allowed the development of analytical methods for the determination of both the β-keto-arylcyclohexamines and the metabolites in LC-HRMS and in LC-MS/MS, providing a starting point for studying their toxicokinetics
Painful and involuntary multiple sclerosis
No full textIntroduction: Pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions may occur in patients with MS. Areas covered: In the present review, we attempt to summarize the current knowledge on the impact pain, dysphagia, respiratory problems, sexual and cardiovascular dysfunctions have in patients with MS. Expert opinion: To effectively manage MS, it is essential that these symptoms are recognized as early as possible and treated by a rehabilitative multidisciplinary approach, based on proven scientific evidence
Uno strano caso di pemfigo seborroico
No full textRiportiamo il caso di un uomo di 74 anni che all’esame obiettivo presentava una lesione eritemato-squamo-crostosa del dorso del naso, di cui riferiva la comparsa e persistenza da 4 mesi. Clinicamente la lesione aveva l’aspetto di un epitelioma. Il paziente nel resto del corpo non presentava altre lesioni, non assumeva farmaci e non riferiva patologie di rilievo. Per un migliore inquadramento diagnostico e per valutare l’estensione della lesione venivano eseguite 5 biopsie (parte superiore, centrale, inferiore, destra e sinistra della lesione). Il referto istologico deponeva per un quadro di cheratosi attinica acantolitica. In considerazione dell’aspetto clinico della lesione si inviava la documentazione fotografica della lesione all’anatomopatologo e si chiedeva una sua rivalutazione. Veniva posta, quindi, diagnosi di pemfigo seborroico con aspetti anche di pemfigo volgare, successivamente confermata con l’immunofluorescenza diretta ed indiretta. Veniva impostata una terapia sistemica steroidea con risoluzione del quadro cutaneo. Il pemfigo seborroico è caratterizzato da piccole bolle a tetto flaccido dalla cui rottura si hanno lesioni squamo-crostose localizzate al centro del viso, cuoio capelluto, regioni medio-toraciche, con decorso lungo e benigno. Il nostro caso è particolare perché il pemfigo seborroico si presentava clinicamente in maniera atipica e per la sovrapposizione di aspetti istologici da pemfigo volgare
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