114 research outputs found
Memorial sites in countries in transition to democracy
No full textThis work is inspired and originated from an experience of cooperation with the Council of Europe, lasted from summer 2005 to the end of 2009, as a member of various delegations that have made observation missions in different countries, mainly belonging to the former Soviet bloc and the former Yugoslavia. In that capacity the author was able to witness firsthand the effects of a policy change on society, which was very rapid after the fall of the Berlin Wall, an event that is a symbol, in those areas, the watershed between two opposed eras. On the one hand, the domain of socialcommunist ideology and on the other that freedom so much dreamed, which later led to considerable social dislocation, very much evident today. The search for memorial sites and their significance is the theme that unites this trip, with the discovery of "intangible areas" but place over the places
Effect of alloy element contents on caustic stress corrosion cracking of several stainless-steels
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Thrombin generation and intracranial atherosclerotic disease in patients with a transient ischaemic attack
No full textIntracranial atherosclerotic disease (ICAD) is responsible for at least 10% of transient ischaemic attacks (TIA). Thrombin generation has been shown to be associated with several atherosclerotic conditions and may be relevant in the pathogenesis of TIA from ICAD.BACKGROUND:
Intracranial atherosclerotic disease (ICAD) is responsible for at least 10% of transient ischaemic attacks (TIA). Thrombin generation has been shown to be associated with several atherosclerotic conditions and may be relevant in the pathogenesis of TIA from ICAD.
OBJECTIVE:
To evaluate the association between thrombin generation and ICAD in patients with TIA.
MATERIALS AND METHODS:
Consecutive patients with confirmed diagnosis of TIA by vascular neurologist were enrolled. Within 24h from diagnosis, all the patients underwent: blood samples including thrombin generation search, electrocardiography, brain CT scan, blood pressure (BP) measurement, supra-aortic echo-Doppler, transcranial Doppler (TCD) and standard echocardiogram. Thrombin generation was measured as endogenous thrombin potential (ETP) in platelet-rich plasma (PRP) and in platelet-poor plasma (PPP), in the presence and in the absence of thrombomodulin (TM).
RESULTS:
120 patients (male 52.5%), aged 69±16years were enrolled. Ten patients on warfarin treatment had significantly lower ETP than the others. Among the remaining, ETP in the presence or absence of TM did not differ according to TOAST classification aetiology (large vessel vs. cardioembolic vs. lacunar vs. others). In PRP, ETP was similar in patients with ICAD and in those without (1748±160 vs. 1851±36nM·min, p=0.393), whereas, ETP measured in presence of thrombomodulin was higher in patients with than in those without ICAD (2045±99 vs. 1715±41nM·min, p=0.011). In PPP, ETP was similar in patients with ICAD and in those without, whereas thrombin peak was higher in patients with ICAD than in those without both in the presence (165±17 vs. 130±5nM, p=0.036) and in the absence of TM (178±19 vs. 142±5nM, p=0.037).
CONCLUSION:
ETP measured in presence of TM is enhanced in patients with ICAD, supporting that thrombomodulin-protein C pathways is relevant in TIA from ICAD. These hypothesis-generating data suggest that thrombin generation may be relevant in cerebral ischaemia from intracranial disease, and justify larger studies
Progetto Survey Isole Tremiti: Studio territoriale dell’arcipelago tremitese
No full textThe Specialization School in Archaeological Heritage of the University of Bologna has promoted an archaeological fieldwork for its pupils, focusing on a territorial study aimed at investigating an area in South-East Italy: the Tremiti Islands, in particular San Domino, San Nicola and Capraia. This project aims at better understanding and enhancing this territory through the analysis of the islands geographical layout between being located in front of Apulia’s coast and, at the same time, their secluded nature. The first aim was to define the different settlement patterns thorough the various historical periods, on the basis of the material culture and the archaeological evidence collected on the field. The survey activity has been implemented also through significant data elaboration: photogrammetry, topographical surveying, documentation and study of
materials, the use of databases and a GIS. The results have confirmed and expanded the previous studies
Morphological characterization and corrosion resistance of tini foams for biomedical applications
No full textLa Carta Archeologica della Media Valle dello Zeravshan (Uzbekistan)
No full textBreve sintesi delle attività e dei risultati della missione archeologica UNIBO a Samarcanda 2001-200
Impact of Inflammatory Cytokine Gene Polymorphisms on Developing Acute Graft-versus-Host Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
No full textSingle nucleotide polymorphisms (SNPs) in gene encoding pro- and anti-inflammatory factors have been associated with the occurrence of aGvHD. We retrospectively tested a wide panel of 38 polymorphisms in 19 immunoregulatory genes, aiming to first establish, in a pediatric HSCT setting, which SNPs were significantly associated with the development of aGvHD. A significant association was found between aGvHD grades II–IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype. aGvHD grades III-IV resulted associated with donor IL10-1082GG, Fas-670CC + CT, and TLR4-3612TT as well as the use of peripheral CD34+ cells as stem cell source. The multivariate analysis confirmed the association between donor IL10-1082GG and Fas-670CC + CT and aGvHD grades II–IV and between donor IL10-1082GG and TLR4-3612TT and aGvHD grades III-IV. In conclusion we found an association between IL10, FAS, and TLR4 in the donor and IL18 in the recipient and an increased risk of developing aGvHD in transplanted children. Knowledge of the SNPs of cytokine genes associated with aGvHD represents a useful tool for an integrated pretransplantation risk assessment and could guide the physicians to an optimal and more accurate HSCT planning
Impact of inflammatory cytokine gene polymorphisms on developing acute graft-versus-host disease in children undergoing allogeneic hematopoietic stem cell transplantation
No full textSingle nucleotide polymorphisms (SNPs) in gene encoding pro- and anti-inflammatory factors have been associated with the occurrence of aGvHD. We retrospectively tested a wide panel of 38 polymorphisms in 19 immunoregulatory genes, aiming to first establish, in a pediatric HSCT setting, which SNPs were significantly associated with the development of aGvHD. A significant association was found between aGvHD grades II-IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype. aGvHD grades III-IV resulted associated with donor IL10-1082GG, Fas-670CC + CT, and TLR4-3612TT as well as the use of peripheral CD34+ cells as stem cell source. The multivariate analysis confirmed the association between donor IL10-1082GG and Fas-670CC + CT and aGvHD grades II-IV and between donor IL10-1082GG and TLR4-3612TT and aGvHD grades III-IV. In conclusion we found an association between IL10, FAS, and TLR4 in the donor and IL18 in the recipient and an increased risk of developing aGvHD in transplanted children. Knowledge of the SNPs of cytokine genes associated with aGvHD represents a useful tool for an integrated pretransplantation risk assessment and could guide the physicians to an optimal and more accurate HSCT planning
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