408 research outputs found
Lotta al brigantaggio. Prevenzione e repressione tra norme e prassi (secoli XVIII-XIX)
No full textQuesto volume offre una lettura integrata del fenomeno del brigantaggio tra storici del diritto, delle istituzioni e storici tout court. Fa da corollario l'indagine sulla "costruzione" politica dell'avversario e l'analisi degli strumenti giuridici messi in atto per contrastare il dissenso
Unlocking Potential and Limits of Kinase Inhibitors: The Highway to Enhanced Cancer Targeted Therapy
No full textKinases are a family of enzymes comprising over five hundred members, which, when overexpressed or hyperactivated, are implicated in the pathogenesis of numerous hematological and solid cancers [...
Cesare Lombroso e il brigantaggio: tesi e malintesi
No full textThis essay aims to analyze the relevance of the fight against post-unification brigandage in the work of Cesare Lombroso, well-known founder of Criminal Anthropology in Italy in the second half of the nineteenth century. In particular, the purpose of the essay is dispelling some myths and clichés on the theorization of innate delinquency and on the weight that the analysis of the controversial phenomenon of brigandage and of the consequent and unfounded accusation of anti-Southernism
Lotta al brigantaggio. Prevenzione e repressione tra norme e prassi (secoli XVIII-XIX)
No full textIl volume offre una lettura integrata del fenomeno del brigantaggio scaturita dal confronto tra storici del diritto, delle istituzioni e storici tout cour
Vascular Endothelial Growth Factor (VEGF) receptors: drugs and new inhibitors
No full textThe recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of these agents and the importance of the research in the field of angiogenesis inhibitors for future oncologic therapy. In this perspective we briefly report the inhibitors which are in clinical use, while we dedicate two wider sections to the compounds which are in clinical trials and to the new derivatives
appearing in the literature. We especially consider the medicinal chemistry aspect of the topic, report the structure-activity relationship studies and the binding mode of some inhibitors as well as the biological data of the compounds discovered in the past five years
Update on statin-associated myopathy symptoms in the view of new clinical management strategies
No full textPurpose of review: Purpose of this review is to highlight the recent findings in terms of clinical aspects, pathogenic mechanisms and managements of statin associated muscle symptoms (SAMS), and focusing on the use of novel therapeutic alternatives in clinical practice. Recent findings: While extensive research has been conducted on SAMS, the precise mechanisms remain unclear. Recent findings continue to explore various aspects, including potential risk factors, diagnostic approaches, and management strategies. Managing SAMS involves a careful assessment to confirm the diagnosis, a stepwise approach to treatment that may include dose adjustments, switching statins, considering alternate-day dosing, and exploring nonstatin therapies, all while prioritizing patient well being and cardiovascular risk reduction through shared decision-making and ongoing monitoring. In recent years, the therapeutic landscape has expanded with the introduction of several novel lipid-lowering agents, providing valuable alternatives for both statin-tolerant and statin-intolerant patients but their use in clinical practice is still limited because of high costs, regulatory limitations and type of administration. Summary: Given the increasing use of both traditional and emerging lipid-lowering therapies, a clear understanding of their comparative safety, particularly regarding musculoskeletal adverse effects, is essential for guiding clinical decision-making
Orexin and Lifestyle Habits: A Meaningful Connection Among Nutrition, Physical Activity, and Sleep Pattern in Health and Diseases
No full textOrexin is a neuropeptide produced in the hypothalamus that plays a key role in regulating slee—wake cycles, energy metabolism, feeding behavior, and physical activity. It exists in two forms, orexin-A and orexin-B, which bind to G protein-coupled receptors OX1R and OX2R with differing affinities. Orexin signaling is widespread in the brain and extends to peripheral tissues, including adipose tissue. Its involvement in hypothalamic and extrahypothalamic circuits suggests a broad role in homeostatic regulation. Dysfunctions in the orexinergic system are implicated in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis, particularly through mechanisms involving sleep disturbances and neuroinflammation. This study examines how orexin influences neural circuits related to arousal, motivation, and motor control. It also explores how physical activity stimulates orexin release, enhancing neuroplasticity and cognitive resilience. In addition, orexin’s role in reward-related feeding, genetic susceptibility to obesity, and brown adipose tissue thermogenesis is discussed. Overall, the orexinergic system represents a vital neurochemical link between physical activity, metabolism, and cognitive health. Although many of its mechanisms remain to be clarified, its central role in integrating energy balance and behavioral responses makes it a promising target for future therapeutic strategies
"Per meriti di brigantaggio". Uso politico e identificazione del brigante nel Regno di Napoli tra età napoleonica e Restaurazione (1799-1815)
No full textI cambiamenti politici e sociali, destinati a mutare radicalmente le società, portano con sé anche delle trasformazioni linguistiche necessarie per indicare ed esprimere concetti e valori prima inesistenti. Le nuove forme della lotta politica, scaturite in massima parte dalla Rivoluzione francese, trasformarono il significato di vecchi termini che caddero in disuso, sostituiti da altri: questo è il caso del lemma brigante, assai utilizzato in Francia che finì con il sostituire nel Regno di Napoli il più vecchio e diffuso termine di bandito
An update on dual Src/Abl inhibitors
No full textc-Src and Bcr-Abl are two cytoplasmatic tyrosine kinases (TKs) involved in the development of malignancies. In particular, Bcr-Abl is the etiologic agent of chronic myeloid leukemia, where Src is also involved; the latter is hyperactivated in several solid tumors. Because of the structural homology between Src and Abl, several compounds originally synthesized as Src inhibitors have also been shown to be Abl inhibitors, useful in overcoming the onset of some types of chronic myeloid leukemia resistances, which frequently appear in the advanced phases of pathology. In recent years, the development of such compounds has been promoted by both excellent preclinical and clinical results, and by the theory that dual or multi-targeted inhibitors might be more effective than selective inhibitors. This review is an update on the most important dual inhibitors already in clinical trials and includes information regarding compounds that have appeared in the literature in recent years
On the Energy Efficiency of IP-over-WDM Networks
No full textIn the next 10 to 15 years the Internet will undergo
a substantial increase especially with respect to the bandwidth required
by end-users. Since the current Internet already consumes
a not-negligible percentage of the total world electricity, reducing
the energy consumption of telecom networks is expected to
become an increasingly-important challenge, being unacceptable
that the Internet energy consumption grows proportionally to the
served bandwidth. In this paper we focus on backbone transport
networks, that serve large aggregated amount of traffic. We
compare three different network architectures which implement
the Wavelength Division Multiplexing (WDM)-based transport
of IP packets over optical fiber links (IP-over-WDM networks).
The differences between these three architectures, which we
identify as IP with no Bypass (IP-NB), IP with Bypass (IPB)
and IP with Bypass and Grooming (IP-BG), concern the
capabilities of performing aggregation of traffic (grooming) and
optical switching. IP-NB architecture performs grooming in every
network node, where the traffic is electronically processed and
forwarded by the IP routers. IP-B enables switching of wavelength
channels directly in the optical domain, thus bypassing
the processing of IP packets in the intermediate IP routers.
This architecture does not provide grooming capabilities, but
it just allows aggregation of different traffic demands to be
established between the same source/destination pairs. IP-BG
architecture represents an intermediate solution between the
previous, since it provides both grooming capabilities (as for IPNB)
in order to efficiently exploit network capacity, and optical
switching (as for IP-B) to reduce expensive electronic processing
operations. We perform a comparative study between these three
architectures showing the trade-off between the reduction of the
power consumption or the cost of the networks, and we analyze
how minimizing one of these two factors can influence the other
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