125 research outputs found
Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells
No full textThe interaction with erythrocytes of four [V V O 2 L 2 ] - complexes, with L = picolinate (pic), 5-cyanopicolinate (picCN), 3-aminopyrazine-2-carboxylate (przNH 2 ), and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate (dhp), was studied. The thermodynamic stability at physiological pH is: [V V O 2 (dhp) 2 ] - > [V V O 2 (przNH 2 ) 2 ] - > [V V O 2 (pic) 2 ] - > [V V O 2 (picCN) 2 ] - . With picCN and pic, V exists at physiological pH as H 2 V V O 4- , with przNH 2 as a mixture of H 2 V V O 4- and [V V O 2 (przNH 2 ) 2 ] - and with dhp as [V V O 2 (dhp) 2 ] - . In the systems with pic and picCN, H 2 V V O 4- and the ligands cross the erythrocyte membrane independently, with dhp the uptake occurs by diffusion, whereas with przNH 2 both the mechanisms are active. Inside erythrocytes stable V IV OL 2 complexes are formed, indicating that there is no relationship with the stability and redox state of the administered compounds and that, if the metal ion changes its oxidation state in the cytosol as V does, unstable complexes in the extracellular medium could become stable inside the cells and contribute to the pharmacological action
Interaction of V(V) complexes formed by picolinic and pyrazinecarboxylic acid derivatives with red blood cells
No full textCharacterization of the compound of vanadium(V) with picolinic acid
No full textSintetizirala sem spojino vanadija(V) s pikolinsko kislino in jo primerjala z že obstoječim standardnim vzorcem z uporabo analiznih tehnik, vključno z IR spektroskopijo, rentgensko praškovno difrakcijo, UV-VIS spektroskopijo ter NMR spektroskopijo. S pomočjo teh analiz sem ugotovila, da imata obe spojini enake značilnosti.I synthesized a vanadium(V) compound with picolinic acid and compared it with an existing standard sample using techniques, including IR spectroscopy, X-ray powder diffraction, UV-VIS spectroscopy, and NMR spectroscopy. Through these analyses, I determined that both compounds exhibit identical characteristics
CCDC 1430329: Experimental Crystal Structure Determination
No full textRelated Article: Ifigenia Tsitsa, Alketa Tarushi, Panagiota Doukoume, Franc Perdih, Andreia de Almeida, Athanasios Papadopoulos, Stavros Kalogiannis, Angela Casini, Iztok Turel, George Psomas|2016|RSC Advances|6|19555|doi:10.1039/C5RA25776J,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 1430331: Experimental Crystal Structure Determination
No full textRelated Article: Ifigenia Tsitsa, Alketa Tarushi, Panagiota Doukoume, Franc Perdih, Andreia de Almeida, Athanasios Papadopoulos, Stavros Kalogiannis, Angela Casini, Iztok Turel, George Psomas|2016|RSC Advances|6|19555|doi:10.1039/C5RA25776J,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Reactions of L-thyroxine with nicotinamide and 3-hydroxypyridine
No full textV sklopu diplomske naloge sem preverjal tvorbo kokristalov oz. soli različnih organskih spojin z L-tiroksinom. Izbrani reagenti so vsebovali različna akceptorska mesta halogenskih vezi. Testiral sem topnost izhodnih reagentov v topilih H2O, DMF in MeOH ter nato izvedel reakcijo teh reagentov z L-tiroksinom v izbranih topilih ter poskušal tvoriti kristale s počasnim izhlapevanjem topil iz steklenih kivet z reakcijsko raztopino. Tvorjene produkte in reagente sem nato analiziral z uporabo rentgenske praškovne difrakcije. V nalogi sem se osredotočil predvsem na reakcije z nikotinamidom in 3-hidroksipiridinom, ki sta dala najboljše rezultate.As part of my diploma thesis, I examined the formation of cocrystals or salts of various organic compounds with L-thyroxine. The selected reagents contained different halogen bond acceptor sites. I tested the solubility of the starting reagents in H2O, DMF and MeOH and then reacted these reagents with L-thyroxine in the selected solvents and attempted to form crystals by slow evaporation of the solvents from glass cuvettes containing the reaction solution. The products and reagents formed were then analysed by X-ray powder diffraction. In this thesis I focused mainly on the reactions with nicotinamide and 3-hydroxypyridine, which gave the best results
CCDC 1430330: Experimental Crystal Structure Determination
No full textRelated Article: Ifigenia Tsitsa, Alketa Tarushi, Panagiota Doukoume, Franc Perdih, Andreia de Almeida, Athanasios Papadopoulos, Stavros Kalogiannis, Angela Casini, Iztok Turel, George Psomas|2016|RSC Advances|6|19555|doi:10.1039/C5RA25776J,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Impact of zinc and vitamins on COVID-19
No full textIzbruh COVID-19 je Svetovna zdravstvena organizacija uradno razglasila za pandemijo. COVID-19 je močno ogrozil zdravje ljudi po svetu in povzročil ogromno gospodarsko škodo.
V času pisanja diplomske naloge še ni bilo znano učinkovito sredstvo proti virusu SARS-CoV-2, zato je bilo treba poiskati nadomestne metode za nadzor širjenja bolezni. Za preprečevanje nadaljnjega širjenja virusa je predpisanih več previdnostnih ukrepov, ki vključujejo karanteno, preventivno umivaje rok, uporaba razkužila in zaščitnih mask. V diplomskem delu sem se posvetila zgolj spletnemu raziskovanju vpliva cinka in vitaminov A, C in D na COVID-19. Ugotovila sem, da cinkovi ioni v kombinaciji z ionofori lahko zaustavijo replikacijo virusa v gostiteljski celici, tako da inhibirajo aktivnost RNA-odvisne RNA polimeraze virusa. Respiratorni trakt je občutljiv na pomanjkanje vitamina A, zato je pomembna dovolj visoka koncentracija cinka v telesu, saj le ta pripomore pri absorpciji vitamina A. Vitamini A, C in D imajo pomembno vlogo pri delovanju imunskega sistema prav tako pa zmanjšajo možnost okužbe z virusom oziroma pripomorejo k lažjemu zdravljenju le te.The COVID-19 outburst was officially declared as a pandemic by the World Health Organisation. Worldwide, COVID-19 has put many people\u27s health at risk and has caused an enormous economic crisis.
While writing this diploma work, an efficient means of fighting the SARS-CoV-2 has not been developed yet, which is why replacement methods for controlling the spread of the disease had to be found. In order to prevent the virus from spreading, several precautionary measures had to be taken, such as quarantining, preventive hand washing, using disinfectants, and wearing protective face masks. In this diploma work, I focused only on researching the impact of zinc and vitamins A, C, and D on COVID-19. I found out that zinc ions, combined with ionophores, can stop the virus replication in the host cell by inhibiting the activity of RNA-dependent RNA polymerase of the virus. The respiratory tract is sensitive to vitamin A deficiency, therefore it is important to maintain a sufficiently high concentration of zinc in our bodies, as it aids the absorption of vitamin A. Vitamins A, C, and D play a significant role in the workings of our immune system and reduce the possibility of viral infection or help make its medical treatment easier
Luminiscence attributes of zinc coordination compounds with indol-3-propionic acid or indol-3-acetic acid ligand with neutral nitrogen ligands
No full textV sklopu magistrske naloge sem sprva sintetiziral spojini [Zn(I3P)2] in [Zn(I3O)2]. Pri sintezi obeh navedenih spojin sem kot izhodno spojino uporabil ZnCl2 in ustrezno kislino (indol-3-propanojsko (I3P-H) in indol-3-ocetne kislino (I3O-H)). Pripravljeni spojini sem nato uporabil kot izhodni spojini pri sintezah z različnimi nevtralnimi dušikovimi ligandi. Sinteze sem izvajal v dveh množinskih razmerjih med izhodno spojino cinka in ligandom (1:1 in 1:2), ob uporabi različnih topil (metanol, etanol, kloroform, voda, aceton, dimetilformamid) v različnih kombinacijah. Nastale produkte sem okarakteriziral z analizo razultatov nekaterih fizikalno-kemijskih metod (rentgensko praškovna analiza (PXRD), rentgenska analiza monokristala (XRD), jedrska magnetna resonanca (1 H NMR). Posnel sem tudi IR spektre, UV-Vis in luminiscenčne spektre produktov v trdnem. Z uporabo navedenih metod sem predvidel sledeče formule dobljenih spojin: [Zn(I3P)2(2,2\u27-bipy)] (2,2\u27-bipy = 2,2\u27-bipiridin), [Zn(I3O)2(4,4\u27-bipy)], [Zn(I3P)2(4,4\u27-bipy)] (4,4\u27-bipy = 4,4\u27-bipiridin), [Zn(I3O)2(4-ampy)2]∙H2O (4 ampy = 4-aminopiridin), [Zn(I3P)2(bipyam)] (bipyam = 2,2\u27-bipiridilamin), [Zn(I3P)2(phen)] (phen = 1,10-fenantrolin), [Zn(I3P)2(neo)], [Zn(I3O)2(neo)] (neo = neokuproin).As a part of my master thesis [Zn(I3P)2] and [Zn(I3O)2] were initially synthesized from ZnCl2 and the corresponding acid (indole-3-propanoic and indole-3-acetic acid). Those two compounds were used as starting compounds in syntheses with various neutral nitrogen ligands. Syntheses were performed in two mass ratios between the initial zinc compound and the ligand (1:1 and 1:2), using different solvents (methanol, ethanol, chloroform, water, acetone, dimethylformamide) in different combinations. The resulting products were characterized by analyzing the results of some methods (X-ray powder analysis (PXRD), single crystal X-ray analysis (XRD), nuclear magnetic resonance (1H NMR). IR spectra, UV-Vis and luminescence spectra of the products were recorded in the solid state. Following formulas of the obtained compounds were predicted: [Zn(I3P)2(2,2\u27-bipy)] (2,2\u27-bipy = 2,2\u27-bipyridine), [Zn(I3O)2(4,4\u27-bipy)], [Zn(I3P)2(4,4\u27-bipy)] (4,4\u27-bipy = 4,4\u27-bipyridine), [Zn(I3O)2(4-ampy)2]∙H2O (4 ampy = 4-aminopyridine), [Zn(I3P)2(bipyam)] (bipyam = 2,2\u27-dipyridylamine), [Zn(I3P)2(phen)] (phen = 1,10-phenanthroline), [Zn(I3P)2(neo)], [Zn(I3O)2(neo)] (neo = neocuproine)
Optimization of the methyl 6-(hydroxymethyl)picolinate for ligand preparation
No full textPri svojem diplomskem delu sem se osredotočil na optimizacijo sinteze metil 6-(hidroksimetil)pikolinata iz dimetil dipikolinata. Izvedel sem reakcije redukcije na 10 g skali pri čemer sem spreminjal hitrost dodajanja reagenta. Za izboljšanje izkoristka sem spreminjal tudi volumen in število ponovitev pri ekstrakciji. S pomočjo TLC sem z mešanjem topil v različnih razmerjih določil najprimernejšo mobilno fazo za čiščenje s kolono. Izvedel sem še eno reakcijo pod nekoliko drugačnimi pogoji na manjši skali. Na koncu sem čistost produktov preveril z 1H NMR analizo.In the thesis, I focused on the optimization of the synthesis of methyl 6-(hydroxymethyl)picolinate from dimethyl dipicolinate. I performed the reduction reactions on a 10 g scale, varying the reagent addition rate. To improve the yield, I also varied the volume and the number of extraction repetitions. Using TLC, I determined the most suitable mobile phase for column purification by mixing solvents in different ratios. I carried out another reaction under slightly different conditions on a smaller scale. Finally, I checked the purity of the products by 1H NMR analysis
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