1,720,972 research outputs found
Generic versus brand-name cardiovascular drugs: A remarkable update
No full text[No abstract available
Registro Tumori Regionale dell'Abruzzo. Report - Anno I. Attività di avvio e analisi: incidenza di tumori maligni, trend 2004-2014
No full textI tassi di incidenza standardizzati, medi annui del periodo 2004-2014, dei più frequenti tumori maligni per tutti i residenti in Abruzzo, sono riportati nella Tabella 1. Nel complesso (tutti i tumori maligni esclusi quelli cutanei non melanomatosi), ogni 10.000 maschi si sono verificati 52.6 nuovi casi ogni anno; 44.3 tra le femmine. Questi valori sono nettamente inferiori ai tassi standardizzati medi nazionali forniti nell'ultimo Rapporto AIRTUM (2015) a pagina 22 (>60 per i maschi; >50 per le femmine), e contemporaneamente superiori agli stessi valori medi nazionali forniti nello stesso Rapporto AIRTUM sia a pagina 68 che 72 (<450 per i maschi e <350 per le femmine del Centro-Sud Italia). Queste discrepanze non devono tuttavia turbare perché derivano da differenze nei calcoli degli stessi tassi. Nello specifico, i tassi riportati a pagina 22 del citato Report sono stati ottenuti dai soli registri con dati aggiornati, presenti soprattutto al Nord Italia e quindi con tassi solitamente più elevati rispetto al Centro-Sud. I tassi riportati alle pagine 68 e 72 sono invece
stati stimati e calcolati, rispettivamente, avendo come popolazione di riferimento la popolazione europea, significativamente più giovane rispetto alla popolazione italiana utilizzata come riferimento nel nostro calcolo. Tale scelta si deve al fatto che il riferimento della popolazione europea è molto datato ed è in fase di aggiornamento, ed i valori aggiornati saranno probabilmente molto più simili alla popolazione italiana rispetto a quelli attuali
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Endoscopic and clinical evaluation of the therapeutic action of a bicarbonate-calcium mineral water in patients with gastroduodenitis
No full textProhibitin: A novel molecular player in KDEL receptor signalling
No full textThe KDEL receptor (KDELR) is a seven-transmembrane-domain protein involved in retrograde transport of protein chaperones from the Golgi complex to the endoplasmic reticulum. Our recent findings have shown that the Golgi-localised KDELR acts as a functional G-protein-coupled receptor by binding to and activating Gs and Gq. These G proteins induce activation of PKA and Src and regulate retrograde and anterograde Golgi trafficking. Here we used an integrated coimmunoprecipitation and mass spectrometry approach to identify prohibitin-1 (PHB) as a KDELR interactor. PHB is a multifunctional protein that is involved in signal transduction, cell-cycle control, and stabilisation of mitochondrial proteins. We provide evidence that depletion of PHB induces intense membrane-trafficking activity at the ER-Golgi interface, as revealed by formation of GM130-positive Golgi tubules, and recruitment of p115, β-COP, and GBF1 to the Golgi complex. There is also massive recruitment of SEC31 to endoplasmic-reticulum exit sites. Furthermore, absence of PHB decreases the levels of the Golgi-localised KDELR, thus preventing KDELR-dependent activation of Golgi-Src and inhibiting Golgi-to-plasma-membrane transport of VSVG. We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF signalling pathway), PHB can act as a signalling scaffold protein to assist in KDELR-dependent Src activation
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Analisi dell'incidenza di neoplasie ematologiche in Abruzzo. Anno 2015
No full textQuesta analisi, necessaria proprio per fornire una risposta basata su più fonti informative alle criticità
sollevate da precedenti studi, condotti rigorosamente dai principali esperti abruzzesi in materia, ma
inevitabilmente limitati dall’utilizzo delle sole SDO quale fonte informativa, conferma sostanzialmente le
stime nazionali fornite dall'AIRTUM, e riduce il potenziale allarme derivante dalle più elevate stime relative
alla Regione Abruzzo. In altri termini, il rischio di neoplasie ematologiche dei cittadini abruzzesi appare nel
complesso simile a quello del resto dei cittadini italiani
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Design and synthesis of a multivalent fluorescent folate-calix[4]arene conjugate: Cancer cell penetration and intracellular localization
No full textA novel fluorescently labeled folate conjugate in which four folic acid units are covalently conjugated with a 7-nitro-benzofurazan fluorophore by means of a calix[4]arene platform was synthesized by using a Cu-catalyzed azide-alkyne cycloaddition reaction (click chemistry). The synthesized construct (FA-C4-NBD) was characterized by mass spectrometry, NMR and fluorescence spectroscopy. Confocal fluorescence microscopy experiments were carried out to evaluate the cell penetration ability of FA-C4-NBD on normal and cancer cells. The cellular uptake of FA-C4-NBD proceeds via folate receptor-mediated endocytosis. FA-C4-NBD is internalized into HeLa cancer cells which express high levels of folate receptors, whereas the uptake into fibroblast NIH3T3 cells which have very low expression levels of folate receptors is negligible. The involvement of the folate receptor was corroborated by competition tests with free folic acid. Co-localization analysis with different organelle markers indicated that FA-C4-NBD is not eliminated by recycling towards the outside of the cell, but accumulates intracellularly in the endo-lysosomal system
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