101,952 research outputs found
Synthesis of New Chiral Nitrogen Containing Diselenide as a Precursor for Selenium Electrophiles
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SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
No full textAn outcome of high mechanical stress in the context of hyperproliferation and increased cellular tension is the reduction in cell volume, that holds the potential to impact cellular density. Both cell size and density homeostasis are integral features of healthy tissues, intricately linked to the regulation of the cell cycle and biosynthesis processes. This connection suggested that achieving density homeostasis could involve a coupling mechanism between the regulation of macromolecular production and osmolytes. Considering the importance of density and protein homeostasis, we decided to explore whether similar mechanisms may play a role in the responses of tumor cells upon mechanical stress.
To shed light on the mechanisms, we have employed several approaches to study the acute alterations in cell size induced by mechanical stress. We used osmotic shocks and compressive stresses, as well as genetic encoded microparticle (GEMs) tracking to infer cytoplasmic density. The combination of these tools with measures of translation rate, polysome profiling, ribogenesis, and protein degradation assays uncovered interesting evidences demonstrating a mechanism that couples the regulation of macromolecular production with rheological adaptation in colorectal cancer cells HCT116. In particular, we have found that the early response to mechanical compression is independent of the mechanistic target of rapamycin complex 1 (mTORC1), while adaptation requires mTORC1 inactivation and subsequent increase of autophagy. Our data provided clues suggesting alternative signaling and biophysical pathways involved in the regulation of protein homeostasis in response to mechanical stress, which provide valuable insights into the pathogenesis of cancer and may represent promising targets for therapeutic intervention
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Nuove stazioni di Tamarix arborea var. arborea e T. chinensis (Tamaricaceae) in Sicilia
No full textTamarix arborea (Sieb. Ex Ehrenb.) Bge. var. arborea e T. chinensis Lour. sono due specie ampiamente diffuse sul territorio siciliano dove, oltre ad essere coltivate a scopo ornamentale, da alcuni anni manifestano una chiara tendenza alla spontaneizzazione. Nell’ambito dell’esplorazione floristica del territorio siciliano, finalizzato ad una più esauriente caratterizzazione del genere Tamarix L. in Italia (1, 2, 3), sono state individuate nuove stazioni di Tamarix arborea var. arborea e T. chinensis.
Tamarix arborea var. arborea è diffusamente coltivata a San Vito Lo Capo (Trapani) come specie ornamentale, mentre allo stato spontaneo è stata raccolta all’interno della Riserva Naturale Orientata “Bosco della Ficuzza, Rocca Busambra, Bosco del Cappelliere e Gorgo del Drago” ad oltre 900 m s.l.m.. Questo ritrovamento assume un particolare significato floristico, in quanto si tratta della prima segnalazione all’interno della Riserva, e fitogeografico perchè per la prima volta segnalata in ambiente submontano nell’entroterra siciliano. In particolare l’esemplare di T. arborea var. arborea è stato rinvenuto in prossimità di una zona umida all’interno dell’ampia fascia in cui la base del massiccio, caratterizzata da detriti di falda di natura carbonatica, verso Nord si compenetrano con argilliti, argille marnose e quarzareniti del Flysh Numidico, dell’Oligocene-Miocene inferiore, su un versante interessato da movimenti di massa. Il piano bioclimatico è il mesomediterraneo (fascia subumida superiore) e la serie edafo-igrofila che caratterizza la stazione è quella del Salice pedicellato (Ulmo canescentis-Saliceto pedicellatae sigmetum).
Anche T. chinensis Lour. è ampiamente diffusa in Sicilia come pianta coltivata ad uso ornamentale e presenta evidenti casi di spontaneizzazione negli ambienti dunali della Sicilia nord-occidentale ed orientale, in particolare sul litorale di Balestrate (Trapani) ed in località Cala mosche inclusa nella Riserva Naturale Orientata “Vendicari”, nel territorio di Noto (Siracusa). Il ritrovamento di T. chinensis in quest’ultima località costituisce la prima segnalazione per la Sicilia orientale.
In fine, in riferimento all’esemplare di T. arborea var. arborea, le dimensioni degli elementi fiorali sono le maggiori finora riscontrate sul territorio italiano (Calabria, Sardegna, Sicilia) e in letteratura
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