1,720,954 research outputs found
Evaluating the Developmental Toxicity of Acid Fuchsin: Insights from the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)
No full textPlease note: no video is available for this presentation.
Acid fuchsin, a synthetic dye widely used in textiles, paper, plastics, and leather industries, contributes to environmental pollution through wastewater discharge. Amphibians, as sensitive bioindicators of environmental health, are particularly vulnerable to the toxic effects of pollutants. To assess the potential developmental toxicity of acid fuchsin, we employed the Frog Embryo Teratogenesis Assay-Xenopus (FETAX), a widely accepted method for detecting environmental teratogens. In this study, early-stage Xenopus embryos were exposed to various concentrations of acid fuchsin (0.1 mg/L to 1000 mg/L) for 96 hours. Mortality, malformations, and embryo lengths were recorded at the end of the exposure period. Statistical analyses, including probit analysis for LC50 (lethal concentration for 50% mortality) and EC50 (effective concentration for 50% malformations), along with ANOVA and Bonferroni’s post hoc tests, were conducted to evaluate the data. Results showed that the 96-hour LC50 exceeded 1000 mg/L, while the 96-hour EC50 for malformations was approximately 120 mg/L. High concentrations of acid fuchsin resulted in significant reductions in embryo length and severe malformations, particularly affecting the spine, eyes, and gut. Our findings suggest that acid fuchsin exhibits teratogenic properties, with malformation rates reaching 100% and severe developmental abnormalities observed at the highest concentrations. These results underscore the potential risk posed by acid fuchsin in wastewater to aquatic organisms and, indirectly, to human health and ecosystems. Further research is essential to explore the long-term effects of acid fuchsin on amphibian populations and to identify effective methods for mitigating synthetic dye pollution in aquatic environments.https://digitalcommons.jsu.edu/ce_jsustudentsymp_2025/1070/thumbnail.jp
The Use of Xenopus Embryos for Determining the Developmental Toxicity of Acid Fuchsin
No full textAcid fuchsin is a dye that is used in materials such as textile fabrics, silk, nylon, wool, and leather. These materials may pollute the water, due to synthetic dye pollution. This pollution can be harmful to the animals in these environments. Amphibians are aquatic organisms that are sensitive to harmful pollutants and there has been a large reduction of amphibian populations in the past 40 years. To determine if acid fuchsin can potentially cause developmental effects to amphibians the Frog Embryo Teratogenesis Assay -Xenopus (FETAX) was used. This assay uses early-stage frog embryos exposed for 4 days (96-hrs) in various concentrations of acid fuchsin. During this time they develop from an early-stage cell blastula to a free-living tadpole. Plastic petri dishes of embryos in 8 MLs of test solution was used as the experimental unit. Four controls and 2 replicates for each concentration were used. Every 24 hours dead embryos were removed, and solutions were renewed. At the end of the four days mortality, malformations and embryo length were recorded. Means, Standard error, probit analysis (for LC50 and EC50(malformation)), ANOVA and Bonferroni’s post hoc test were calculated using Systat. The teratogenic potential was calculated using the formula 96-hr LC50/96-hr EC50(malformation). The 96-hr LC50 was \u3e1000 and the 96-hr EC50(malformation) was approximately 120 mg/L. At the high concentrations length was significantly affected. Also, there were severe malformations of spine, eye and gut. These preliminary results indicate that acid fuchsin may be teratogenic and further testing is needed.https://digitalcommons.jsu.edu/ce_jsustudentsymp_2023/1059/thumbnail.jp
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
