2,196 research outputs found
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Intermittent Fasting Promotes Fat Loss with Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice
No full textClinical studies indicate alternate day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet (HFD; 45% fat) ad libitum for 8 weeks to promote an obese phenotype. Mice were divided into 4 groups and either maintained on ad libitum HFD (HFD), received alternate day access to HFD (IMF- HFD), switched to ad libitum low fat diet (LFD; 10% fat), or received IMF of LFD (IMF- LFD). After 4 weeks, IMF-HFD (~13%) and IMF-LFD (~18%) had significantly lower body weights than HFD. Body fat was also lower (~40-52%) in all diet interventions. Lean mass was increased in the IMF-LFD (~12-13%) compared with HFD and IMF-HFD groups. Oral glucose tolerance AUC was lower in the IMF-HFD (~50%), whereas insulin tolerance AUC was reduced in all diet interventions (~22-42%). HPLC measurements of hypothalamic tissue homogenates indicated higher (~55-60%) norepinephrine (NE) content in the anterior regions of the medial hypothalamus of IMF compared with ad libitum fed groups, whereas NE content was higher (~19-32%) in posterior regions in the IMF-LFD group only. Relative gene expression of Npy in the arcuate nucleus was increased (~65-75%) in IMF groups. Our novel findings indicate that intermittent fasting produces alterations in hypothalamic NE and NPY, suggesting an involvement in the counter regulatory processes of short-term weight loss are associated with an IMF dietary strategy.Peer reviewe
Characterization and structure in the development of Tudor comedy
No full textThe role of characterization in dramatic structure is assessed by theoretical criteria.
Characters who perform actions necessary for the completion of the narrative sequence are
said to be "bound" to the narrative; those without such obligations are "free". Characters
who maintain a single, constant meaning during the course of a play are said to be "static";
characters who change or develop into new roles are "dynamic". Horatian decorum
demanded that comic characters be static, and the characters of Plautine and Terentian
tradition were almost always bound to narrative intrigue. However, evaluations of six
Tudor comedies show an increasing use of non-classical characterization within the comic
form.
In the early comedies lohan lohan and Roister Doister all characters are bound and
static, yet the impetus to enlarge the role of characterization is evident. The characters of
lohan lohan are expanded from their French source, and Roister Doister includes
extraneous episodes in which Udall displays his braggart hero. Free characters abound in
Misogonus; as well the play brings dynamic characterization into the scope of comedy with
the conversion of its prodigal son.
Free characters offer new possibilities of non-narrative plotting. In comedies of the
1580s favourite traditional characters appear as diversions outside the action, and thematic
arrangements of characters inform the increasingly complex plots. Lyly stresses the
symbolic potential of characters in Endimion, whereas Greene uses dynamic
characterization to heighten the illusion of independent figures in Friar Bacon and Friar
Bungay. Love's Labour's Lost exposes the limitations of comic artifice by pulling the
characters between convention and individualization.
By the end of the sixteenth century free and dynamic characters had become
common, and characterization had established a sizable claim on the design of English
comedy. These developments set the English form apart from its neoclassical counterparts
El pronunciamiento mexicano del siglo XIX : Hacia una nueva tipología
No full textTras la guerra de Independencia (1810-1821) estallaron más de 1 500 pronunciamientos entre el Plan de Iguala de 1821 y el Plan de Tuxtepec de 1876. En varios casos degeneraron en enfrentamientos de una violencia atroz como el saqueo del Parián en la ciudad de México de 1828. En otros resultaron en guerras civiles brutales (1832, 1854-1855, 1858-1860). En muchos casos, sin embargo, sus demandas fueron atendidas o sofocadas dependiendo de cuántos pronunciamientos de adhesión recibieron. Este artículo busca redefinir la práctica del pronunciamiento en México, haciendo hincapié en el protagonismo que tuvieron grupos e instituciones civiles al adoptar este medio legítimo, aunque no constitucional, para forzar cambios políticos tanto a nivel regional como nacional durante las primeras décadas nacionales.Peer reviewe
Blind orogen: Integrated appraisal of multiple episodes of Mesoproterozoic deformation and reworking in the Fowler Domain, western Gawler Craton, Australia
No full textThe Fowler Domain in the western Gawler Craton in southern Australia is a poorly exposed region that can only presented be explored using a combination of information from drilling and potential field geophysics. Regional maps of the Total Magnetic Intensity (TMI) field of the Fowler Domain highlight an anastomosing system of terrain-scale shear zones that bound four crustal-scale tectonic blocks: from west to east, the Colona, Barton, Central and Nundroo blocks. Integrated thermobarometry and electron microprobe chemical dating of metamorphic monazites from drillholes in the Fowler Domain suggest that the Colona Block in the west underwent two mid-crustal amphibolite grade metamorphic events at ca. 1643 and 1600 Ma. The younger age corresponds to the timing of regional high-grade metamorphism in the Barton Block. Together, the age data suggest that the western Fowler Domain underwent a major tectonothermal event at ca. 1600 Ma. In contrast, regional lower crustal metamorphism in the Nundroo Block, which forms the eastern Fowler Domain, occurred at ca. 1545 Ma. In both the Barton and Nundroo Blocks, petrological relationships, mineral zoning, and pressure-temperature (P-T) modelling suggest the terrains cooled in the mid- to lower crust, rather than undergoing exhumation immediately following peak metamorphism. Age data from the geophysically defined shear zone systems that bound the blocks suggest that exhumation of these lower crustal domains occurred between ca. 1470 and 1450 Ma and was associated with transpressional reactivation of the terrain during the Coorabie Orogeny. A key finding of this study is that the tectonic evolution of the crustal blocks in the Fowler Domain was not in concert until at least 1500 Ma. Thus, the evolution of the individual blocks is unlikely to be related to the macroscopic character of the terrain defined by the regional-scale shear zone systems, which are one of the youngest tectonic imprints on the Fowler Domain. Coincident gravity and magnetic forward modelling of significant bounding faults suggests the shear zones form a steeply dipping transpressional array, consistent with the observed metamorphic field character of the different blocks. This study provides a demonstration of the integration of geophysical and petrological approaches to investigate the time-integrated tectonic evolution of poorly exposed basement terrains. © 2008 Elsevier B.V. All rights reserved.Jane L. Thomas, Nicholas G. Direen and Martin Han
Level 3: Sophie et sa grand-mère mystérieuse/ Sophie and her mysterious grandmother
No full textThis book is dedicated to all young students who want to learn. There is always more to learn and a way to learn it. Never stop dreaming.
About the Author: My name is Nicholas Fabiano. I\u27m American. I am a student at the University of Kennesaw State in the United States. I\u27m studying electronic engineering. I like traveling, horse riding, boxing and spending time with my friends and family.
Ce livre est dédié à tous les jeunes étudiants qui veulent apprendre. Il y a toujours plus à apprendre et un moyen de l\u27apprendre. N\u27arrêtez jamais de rêver.
Je m’appelle Nicholas Fabiano. Je suis américain. Je suis étudiant à l’Université de Kennesaw State aux États-Unis. J’étudie l’ingénierie électronique. J\u27aime voyager, faire du cheval, boxer et passer du temps avec mes amis et ma famille.https://digitalcommons.kennesaw.edu/globallib/1003/thumbnail.jp
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
Status of anadromous salmonids in Oregon coastal basins
No full textThomas E. Nickelson, Jay W. Nicholas, Alan M. McGie, Robert B. Lindsay, Daniel L. Bottom (Research and Development Section, Oregon Department of Fish and Wildlife), and Rodney J. Kaiser, Steven E. Jacobs (Ocean Salmon Management, Oregon Department of Fish and Wildlife).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 71-81).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Impacts of prescribed fire on water use efficiency and photosynthetic capacity in upland pine and oak forests
No full textA comparative analysis of the impacts of prescribed fire on an oak/pine and two pine dominated forest in the Northeastern US was conducted. Effects of prescribed fire on water use and photosynthetic capacity of overstory pines were estimated by sap-flux rates and photosynthetic measurements on Pinus rigida Mill. Study sites had two sap-flux plots, one experiencing prescribed fire and one control plot. Data were collected between 2011-2013. Control and burned plots were compared both before and after the fires. We found that photosynthetic capacity in terms of Rubisco-limited carboxylation rate (VCmax), carboxylation efficiency, and intrinsic water use efficiency were significantly greater in the burned vs. the control plot post-fire, while instantaneous internal to external CO2 concentration was significantly lower. Furthermore, pines in the pine dominated stands were less affected than pines in the mixed oak/pine stand, as δ13C and isotopic water use efficiency were significantly lower and water use efficiency and carboxylation efficiency were increased in the oak/pine stand post-fire compared to the control plot, but not in the pine dominated stands. Average daily sap-flux rates exhibited different patterns for each stand type due to differences in fuel consumption, increasing compared to control plots in pine dominated sites and decreasing in the oak/pine stand. Finally, when analyzed on the canopy scale, pines in pine-dominated forests were better suited to capitalize on available resources, as they were more sensitive to changes in vapor pressure deficit (VPD) in regards to transpiration, while pines in the oak/pine forest were unaffected in terms of stomatal responses to VPD. Therefore, prescribed fire affects physiological functioning and water use of pines, but many other factors can alter the degree to which these trees are affected, because results are dependent on stand type and fuel consumption differences, making broad-scale generalizations on the effects of prescribed fire difficult.M.S.Includes bibliographical referencesIncludes vitaby Nicholas J. Carl
"Reading from within": Nicholas of Lyra, the sensus iteralis, and the structural logic of "The Canterbury Tales".
No full textLike certain of his more reactionary religious contemporaries (most notably, Nicholas of Lyra, O.F.M., and John Wyclif), Chaucer concerns himself with critically reflexive literature. Through his various narrative and exegetical efforts, he produces--in The Canterbury Tales especially--what amounts to "Christian midrashim" or a literary tarqum as he, like Nicholas and Wyclif before him, directly addresses matters of textual and referential authority, of relational significances, and of the text's apparently intended personal effects. Reflecting the logic and concerns of the central Text of the age and apparently formulating their shared concept of the literal, of its signification, and of its function from Hebraic rather than Latin referential categories, each of these writers after his fashion and field calls for a return to ethical and social praxis based upon a responsible interpretation of the Divine Word according to its inherent logic and meaning. Being concerned to re-establish the pertinence of auctorite for the individual and the age, they thus present "right reading" as an intellectual endeavour under moral imperative. Involving both author and reader in the text, they clarify the sensus literalis (the essential significance of a text) as being not only "what the words signify" (Augustine), but what the words were intended to signify by their Author--as this is supported by the body of received ecriture and as it is accessible to those who approach the text in spiritual and moral readiness, prepared to engage actively the material (and its Author) by activating it in their own immediate experience. My use of such terms as midrashim and tarqum from the Jewish tradition to describe Chaucer's unique contribution to Fourteenth century literature is quite intentional, for it foregrounds the seminal--and Semitic--source, semiotic, and structural logic that underlies the particular theory of the sensus literalis which Nicholas develops from a marriage of rabbinical and patristic sources, which Wyclif gives a distinctively English expression and application, and which Chaucer seems to adapt to poetic forms. My thesis, attempting to deal in a fuller sense with referential meaning generally and with the sensus literalis specifically, explores the ways in which Nicholas, Wyclif, and, after them, Chaucer approach the deeper significance of the literal. (Abstract shortened by UMI.
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