1,720,976 research outputs found
Gaining insight into the complexity of pain in people with haemophilia from a biopsychosocial perspective
No full textAbstract: Joint pain is the hallmark of haemophilia, therefore it seems clinically rather a musculoskeletal (MSK) than a bleeding disorder. Unlike other chronic MSK disorders, pain assessment in people with haemophilia (PwH) remains mainly focused on the structural evaluation of their joints. While there is currently insufficient knowledge about the (patho)physiology, underlying pain mechanisms and biopsychosocial context of pain in PwH. Presumably, this explains the fact that, to date, only a limited number of haemophilia-specific pain management options exist, that PwH suffer from chronic pain and that they report reduced health-related quality of life (HR-QoL). Therefore, this PhD thesis aimed to comprehensively explore pain in PwH from a biopsychosocial perspective, dividing the research into three parts: The first part described a systematic literature review to identify the coping strategies used by PwH to manage their pain. It served as an encouragement for healthcare professionals to promote effective cognitive-emotional behavioral pain coping strategies, as inadequate coping strategies can lead to negative health outcomes. The second part involved a longitudinal pain study in people with (Sub)Acute Low Back Pain ((S)ALBP), a related chronic MSK condition. The study aimed to explore the associations between psychophysical and psychological factors at baseline and disability after a 3-month follow-up. While no significant associations were found, the study suggests that unhelpful psychological factors like kinesiophobia can negatively impact disability and contribute to chronicity. The third part focused on a longitudinal pain study in PwH. This section included three chapters: -Chapter 3 investigated pain sensitivity, modulation, and pain-related psychological factors in PwH and healthy volunteers, revealing differences, particularly in PwH with widespread pain. -Chapter 4 applied the International Association for the Study of Pain (IASP) clinical criteria to classify PwH and identified a small group with suspected predominant nociplastic pain. -Chapter 5 reported results from a prospective study in PwH linking baseline pain-related and psychological factors to pain interference with daily functioning at 12-month follow-up. The findings from this PhD thesis emphasize the multidimensional and biopsychosocial context of pain in haemophilia and suggest the presence of different pain phenotypes and psychological profiles within PwH. The thesis concludes by suggesting future research directions, including expanding comparisons with different populations, conducting experimental studies to develop tailored pain management strategies, and ultimately improving PwH\u2019s HR-QoL
Gaining insight into the complexity of pain in people with haemophilia from a biopsychosocial perspective
No full textJoint pain is the hallmark of haemophilia, therefore it seems clinically rather a musculoskeletal (MSK) than a bleeding disorder. Unlike other chronic MSK disorders, pain assessment in people with haemophilia (PwH) remains mainly focused on the structural evaluation of their joints. While there is currently insufficient knowledge about the (patho)physiology, underlying pain mechanisms and biopsychosocial context of pain in PwH. Presumably, this explains the fact that, to date, only a limited number of haemophilia-specific pain management options exist, that PwH suffer from chronic pain and that they report reduced health-related quality of life (HR-QoL). Therefore, this PhD thesis aimed to comprehensively explore pain in PwH from a biopsychosocial perspective, dividing the research into three parts: The first part described a systematic literature review to identify the coping strategies used by PwH to manage their pain. It served as an encouragement for healthcare professionals to promote effective cognitive-emotional behavioral pain coping strategies, as inadequate coping strategies can lead to negative health outcomes. The second part involved a longitudinal pain study in people with (Sub)Acute Low Back Pain ((S)ALBP), a related chronic MSK condition. The study aimed to explore the associations between psychophysical and psychological factors at baseline and disability after a 3-month follow-up. While no significant associations were found, the study suggests that unhelpful psychological factors like kinesiophobia can negatively impact disability and contribute to chronicity. The third part focused on a longitudinal pain study in PwH. This section included three chapters: - Chapter 3 investigated pain sensitivity, modulation, and pain-related psychological factors in PwH and healthy volunteers, revealing differences, particularly in PwH with widespread pain. - Chapter 4 applied the International Association for the Study of Pain (IASP) clinical criteria to classify PwH and identified a small group with suspected predominant nociplastic pain. - Chapter 5 reported results from a prospective study in PwH linking baseline pain-related and psychological factors to pain interference with daily functioning at 12-month follow-up. The findings from this PhD thesis emphasize the multidimensional and biopsychosocial context of pain in haemophilia and suggest the presence of different pain phenotypes and psychological profiles within PwH. The thesis concludes by suggesting future research directions, including expanding comparisons with different populations, conducting experimental studies to develop tailored pain management strategies, and ultimately improving PwH’s HR-QoL.(MOTR - Sciences de la motricité) -- UCL, 202
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Application of the IASP Grading System to Identify Underlying Pain Mechanisms in Patients with Knee Osteoarthritis:A Prospective Cohort Study
Full text linkObjectives: This study aimed to apply the International Association for the Study of Pain (IASP) grading system for identifying nociplastic pain in knee osteoarthritis (KOA) awaiting total knee arthroplasty (TKA) and propose criteria to fine-tune decision-making. In addition, the study aimed to characterize a "probable"versus "no or possible"nociplastic pain mechanism using biopsychosocial variables and compare both groups in their 1-year post-TKA response. Methods: A secondary analysis of baseline data of a longitudinal prospective study involving 197 patients with KOA awaiting total TKA in Belgium and the Netherlands was performed. Two approaches, one considering 4 and the other 3 pain locations (step 2 of the grading system), were presented. Linear mixed model analyses were performed to compare the probable and no or possible nociplastic pain mechanism groups for several preoperative biopsychosocial-related variables and 1-year postoperative pain. Also, a sensitivity analysis, comparing 3 pain mechanism groups, was performed. Results: Thirty (15.22% - approach 4 pain locations) and 46 (23.35%-approach 3 pain locations) participants were categorized under probable nociplastic pain. Irrespective of the pain location approach or sensitivity analysis, the probable nociplastic pain group included more woman, was younger, exhibited worse results on various preoperative pain-related and psychological variables, and had more pain 1-year post-TKA compared with the other group. Discussion: This study proposed additional criteria to fine-tune the grading system for nociplastic pain (except for discrete/regional/multifocal/widespread pain) and characterized a subgroup of patients with KOA with probable nociplastic pain. Future research is warranted for further validation.</p
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