1,721,022 research outputs found
Oral field cancerization: History and future perspectives
Full text linkNotwithstanding extended surgical approaches or adjuvant chemoradiotherapy, the development of multiple neoplastic lesions arising in the oral cavity after treatment still represents a critical clinical challenge in the management of patients with oral squamous cell carcinoma. Such clinical behavior of oral squamous cell carcinoma is nowadays better known as "field" cancerization effect as suggested by Slaughter, the author that for the first time tried to describe it in a scientific paper. Field cancerization is now widely accepted not only in head and neck oncology but also in other anatomical districts as well as in different types of epithelial neoplasia. A brief history of the theory of field cancerization is here proposed and future perspectives deriving from new molecular techniques are discussed
Peripheral nerve mucoid degeneration involving the sciatic nerve
Full text linkPeripheral nerve mucoid degeneration (PNMD) is a rare non-neoplastic degenerative condition characterized by endoneural deposit of mucoid matrix. Herein, we report a case of PNMD involving the sciatic nerve with preoperative features, surgical treatment and pathological findings
A case of invasive solid papillary breast carcinoma resembling tall cell variant of papillary thyroid carcinoma
No full textInvasive solid papillary breast carcinoma
resembling the tall cell variant of papillary thyroid
neoplasms (BPTC) is an infrequent entity, unrelated to thyroid
carcinoma, with 40 cases described in literature. Histologically
it is composed of bland looking neoplastic epithelial
cells arranged in papillary, solid, and follicular structures,
separated by fibrous bands. Cells have abundant eosinophilic
cytoplasm and nuclei show occasional grooving and inclusions.
Psammoma bodies or granular calcifications can be
seen as well as eosinophilic/amphophilic colloid-like secretions.
These tumors display a triple-negative profile although
associated with low aggressive potential. We report a new
case diagnosed at our institution earlier in 2017
Standardized approach for evaluating tumor infiltrating lymphocytes in canine mammary carcinoma: Spatial distribution and score as relevant features of tumor malignancy
Full text linkNeoplastic cells, through immunoediting mechanisms, can establish a state of immunosuppression to evade host immune defenses. The aims of this study were: (1) to validate a standard method for assessing tumor infiltrating lymphocytes (TILs) in canine mammary carcinoma by applying international human breast cancer guidelines; (2) to investigate if the TILs population was composed of a subset of regulatory T lymphocytes (Tregs); and (3) to evaluate the relationship between the number of TILs and Tregs and the biological behavior of the tumors. One hundred and twenty-nine canine mammary tumors were retrospectively selected for this study. Histological diagnosis, grading and histological evaluation of TILs was performed on hematoxylin and eosin-stained sections. TILs were evaluated using a three-tier semiquantitative method, previously validated in human medicine, based on the percentage of TILs (0–10%, 11–40% and 41–90%). Lymphocyte immunophenotype was confirmed by CD3 and CD79, while an anti-FoxP3 antibody was used to determine the presence of Tregs. The number of stromal TILs and invasive front TILs significantly correlated with each other (P < 0.0001) and increased with increasing histological grade (P = 0.002 and P = 0.004, respectively). A subset of TILs was composed of FOXP3+ Tregs. Stromal Tregs and invasive front Tregs were associated with stromal TILs and invasive front TILs (P = 0.03; P = 0.01 and P = 0.003; P = 0.007, respectively). In conclusion, in canine mammary carcinomas, an increased number of stromal and invasive front TILs is associated with increased malignancy and significant increase of Tregs that could lead to immunosuppression and evasion of the host immune system
Oral sialadenoma papilliferum with kras mutation in a patient with linear nevus sebaceous syndrome
Full text linkLinear nevus sebaceous syndrome (LNSS) is a rare neurocutaneous syndrome part of the epidermal nevus syndromes group, characterized by the presence of sebaceous nevi and other extracutaneous lesions genetically related to RAS family gene mutations. Sialadenoma papilliferum (SP) is a rare benign intraoral neoplasm which is usually BRAF or HRAS mutated. We report a case of a young female girl diagnosed with a LNSS who developed a SP which had a KRAS mutation. This is the first case of SP with a KRAS mutation in the context of a LNSS
EVALUATION OF IMMUNOHISTOCHEMICAL AND BIOMOLECULAR PARAMETERS AS MARKERS OF THE BIOLOGICAL BEHAVIOUR OF HEAD AND NECK CARCINOMAS: PRELIMINARY RESULTS OF A MULTICENTER ITALIAN PROJECT.
No full textThe use of proteoglycans as markers of the biological behaviour of head and neck carcinomas: interim results
No full text- …
