2,083 research outputs found
Author Response: Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome
No full textWe greatly appreciated the comment by Dr. Graber on our case.1 To date, kidney involvement associated with TREX1 sequence variations has been sparsely reported in the context of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S). Specifically, different subtypes of kidney involvement have been described in RVCL-S, including thrombotic microangiopathy (TMA) and glomerulosclerosis.2-4
As for our case, unfortunately, TREX1 analysis was not included in the genetic panel. However, a diagnosis of RVCL-S was unlikely, given the optimal response to eculizumab. Indeed, TREX1-related TMA and leukoencephalopathy have been suggested to be driven by dysregulated type-1 interferon pathways.5 Therefore, the pathophysiologic association between TREX1 sequence variations and endothelial damage is supposed to be independent of complement and should not improve after anticomplement treatment. In addition, after 14 months from onset, no other episodes of leukoencephalopathy occurred in our patient, and she was totally weaned from hemodialysis.
To sum up, even if in our case RVCL-S was a remote possibility, we agree with Dr. Graber's suggestion to consider TREX-1 analysis in patients presenting with acute leukoencephalopathy and small vessel kidney disease. Close collaboration between neurologists and nephrologists remains the key point to promptly recognize such a critical condition
La critica italiana e le culture del progetto (1945-1960): strumenti, temi, attori
No full textMostra e presentazione finale dei lavori degli studenti del Dottorato di Ricerca in Architettura dedicati all’analisi di progetti editoriali italiani inerenti la critica del design e dell’architettura (in collaborazione con Daniele Baratta, Ugo Cornia, Giulia Favaretto, Riccardo Foschi, Elisabetta Caterina Giovannini, Gioia Laura Iannilli, Stefano Politi, Davide Prati, Angela Santangelo, Alessandro Tognon). Il seminario - a cura di Andrea Borsari, Elena Formia, Giovanni Leoni con Matteo Cassani Simonetti e Matteo Sintini – conclude un’attività condotta con gli studenti del Dottorato di Ricerca in Architettura e dedicata a proporre una riflessione sugli strumenti e le figure della critica elaborati dalla cultura italiana del progetto tra il 1945 e il 1960. L'attività è stata svolta nell'ambito della ricerca Mapping.Crit.Arch.: Architectural criticism XXth and XXIth centuries, a cartography finanziata dall'Agence Nationale de la Recherche (Francia) e in vista del Second International Workshop a Bologna (4-5 ottobre 2016), alla cui organizzazione il Dottorato in Architettura contribuisce (mac.hypotheses.org)
La critica italiana e le culture del progetto (1945-1960): strumenti, temi, attori
No full textIl seminario - a cura di Andrea Borsari, Elena Formia, Giovanni Leoni con Matteo Cassani Simonetti e Matteo Sintini – conclude un’attività condotta con gli studenti del Dottorato di Ricerca in Architettura e dedicata a proporre una riflessione sugli strumenti e le figure della critica elaborati dalla cultura italiana del progetto tra il 1945 e il 1960. L'attività è stata svolta nell'ambito della ricerca Mapping.Crit.Arch.: Architectural criticism XXth and XXIth centuries, a cartography finanziata dall'Agence Nationale de la Recherche (Francia) e in vista del Second International Workshop a Bologna (4-5 ottobre 2016), alla cui organizzazione il Dottorato in Architettura contribuisce (mac.hypotheses.org). Mostra e presentazione finale dei lavori degli studenti del Dottorato di Ricerca in Architettura dedicati all’analisi di progetti editoriali italiani inerenti la critica del design e dell’architettura (in collaborazione con Daniele Baratta, Ugo Cornia, Giulia Favaretto, Riccardo Foschi, Elisabetta Caterina Giovannini, Gioia Laura Iannilli, Stefano Politi, Davide Prati, Angela Santangelo, Alessandro Tognon)
Evaluating dalfampridine for the treatment of relapsing-remitting multiple sclerosis: does it add to the treatment armamentarium?
No full textIntroduction: Multiple sclerosis (MS) is a demyelinating disease, causing axonal damage and disability. Dalfampridine (DAL) is an extended-release formulation of 4-aminopyridine (4AP) and broad-spectrum voltage-dependent potassium channel blocker that is reported to improve motor, visual and cognitive functions. Furthermore, it is presently the only approved drug for walking impairment in MS. Areas covered: Herein, the authors evaluate DAL as a relapsing-remitting MS treatment, reporting and commenting on all aspects of the drug including its chemistry, safety, pharmacokinetics, and cost-effectiveness. A bibliographic search was performed on PubMed using the terms 'dalfampridine OR fampridine OR 4-aminopyridine'. Expert opinion: Evidence from post-marketing studies suggests that DAL, consistent with the effects of 4AP, may not only improve walking speed, but also arm function, fatigue, mood and cognition through restored nerve conduction in central nervous system demyelinated areas. Long-term safety data confirm that the approved dose of 10 mg twice daily is generally well tolerated. However, despite the reported efficacy, the extent of the benefits is limited in real life activities, although significant improvements have been demonstrated in the clinical setting. Patients often complain of side effects (such as cramps and painful paraesthesia) or lack of efficacy. Also, its considerably higher pricing in comparison to 4AP represents an important limitation
Antithrombotic treatment of cervical arterial dissection: Big data needed to inform long-term management
No full textGalileo, measurement of the velocity of light, and the reaction times
No full textAccording to the commonly accepted view, Galileo Galilei devised in 1638 an experiment that seemed able to show that the velocity of light is finite. An analysis of archival material shows that two decades later members of the Florence scientific society Accademia del Cimento followed Galileo guidelines by actually attempting to measure the velocity of light and suggesting improvements. This analysis also reveals a fundamental difference between Galileo's and Florence academy's methodologies and that Galileo's experiment was, in some respects, a pioneering work affecting also the history of the psychology of perception
Teaching NeuroImage: Partially Reversible Widespread Leukoencephalopathy Associated With Atypical Hemolytic Uremic Syndrome
No full textA 43-year-old woman presented with altered mental status and hypertension. She had a 3-day history of oliguria. The blood test detected microangiopathic hemolytic anemia, thrombocytopenia, and severe kidney injury. The absence of shiga-like toxin, ADAMTS13 autoantibodies, and normal ADAMTS13 activity were consistent with a diagnosis of atypical hemolytic uremic syndrome (aHUS) and then confirmed by a renal biopsy. Genetic tests (CFH, CFHR1-5, MCP/CD46, CFI, C3, CFB, THBD, and DGKE) were unremarkable. Nevertheless, a history of anemia and kidney failure in her younger brother suggested a genetic etiology.
Brain MRI revealed extensive T2 FLAIR hyperintensities. Treatment with eculizumab and twice-weekly hemodialysis resulted in prompt mental recovery and improvement of MRI abnormalities. aHUS is an ultra-rare complement-mediated kidney disease occasionally associated with neurologic involvement.1 Less extensive T2 FLAIR abnormalities involving every CNS structure have also been reported in diarrhea-associated HUS.2 Here, we presented a case of aHUS-related widespread leukoencephalopathy partially reverting on treatment with eculizumab and hemodialysis
sj-docx-1-eso-10.1177_23969873231198324 – Supplemental material for Epidemiology and treatment of atraumatic subarachnoid hemorrhage over 10 years in a population-based registry
No full textSupplemental material, sj-docx-1-eso-10.1177_23969873231198324 for Epidemiology and treatment of atraumatic subarachnoid hemorrhage over 10 years in a population-based registry by Chiara Ragaglini, Matteo Foschi, Federico De Santis, Anna Laura Molliconi, Francesco Conversi, Enrico Colangeli, Raffaele Ornello and Simona Sacco in European Stroke Journal</p
La critica italiana e le culture del progetto (1945-1960): strumenti, temi, attori
No full textIl seminario - a cura di Andrea Borsari, Elena Formia, Giovanni Leoni con Matteo Cassani Simonetti e Matteo Sintini – conclude un’attività condotta con gli studenti del Dottorato di Ricerca in Architettura e dedicata a proporre una riflessione sugli strumenti e le figure della critica elaborati dalla cultura italiana del progetto tra il 1945 e il 1960. L'attività è stata svolta nell'ambito della ricerca Mapping.Crit.Arch.: Architectural criticism XXth and XXIth centuries, a cartography finanziata dall'Agence Nationale de la Recherche (Francia) e in vista del Second International Workshop a Bologna (4-5 ottobre 2016), alla cui organizzazione il Dottorato in Architettura contribuisce (mac.hypotheses.org). Mostra e presentazione finale dei lavori degli studenti del Dottorato di Ricerca in Architettura dedicati all’analisi di progetti editoriali italiani inerenti la critica del design e dell’architettura (in collaborazione con Daniele Baratta, Ugo Cornia, Giulia Favaretto, Riccardo Foschi, Elisabetta Caterina Giovannini, Gioia Laura Iannilli, Stefano Politi, Davide Prati, Angela Santangelo, Alessandro Tognon)
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