1,721,354 research outputs found

    From Space To Place

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    Proceedings of the international conference focusing on the study and conservation of archaeological and ancient landscapes through integrated technologies and virtual reality. Topics include: Remote sensing, archaeology, landscape, environment, ecosystem, image processing, virtual reality, 3D visualization, conservation, geophysics, photogrammetry, open source and Web-GIS as applied to archaeological heritage. Organized by the Italian National Research Council and University of Sienna, and under the patronage of the Institute for Technologies Applied to Cultural Heritage, UNESCO Natural Sciences Sector, and European EPOCH Network of Excellence, the conference will be held in Rome, Italy at the National Research Council. It follows the 1st Int'l Conference on Remote Sensing Archaeology, organized by the Chinese Academy of Sciences in Beijing and hosted by the Joint Laboratory of Remote Sensing Archaeology (JLRSA). Sense of place is also sense of time, difference between space and place, between 'global' and 'local'. The world process of globalization is removing places and multiplying spaces, reducing the cultural differences. In particular the dissemination of not-places, stations, hypermarkets, hotels, etc. risks to make uniform our perception, reducing what we perceive of the world to a few mental maps. Therefore we want to highlight one the fundamental tasks of remote sensing archaeology, namely, the capacity to use spatial technologies for recovering and identifying places and the sense of place in collaboration with the local communities. A Remote Sensing International School for archaeologists, site managers and environmental experts will be organized in Grosseto, Italy the week preceeding the Conference

    The mitochondrial permeability transition

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    The mitochondrial permeability transition pore (PTP) is a high conductance channel of the inner membrane whose opening leads to an increase of permeability to solutes with molecular masses up to about 1500 Da, the ‘permeability transition’. This potentially catastrophic event has long been known, yet the molecular bases for its occurrence remain unsolved despite its established importance in several in vivo models of pathology. Recent studies based on inactivation of genes encoding putative pore components (such as the adenine nucleotide translocators and the voltage-dependent anion channel) have raised major questions about the involvement of these proteins in PTP formation, yet they have conclusively demonstrated the role of matrix cyclophilin D as the mitochondrial receptor for the desensitizing effects of cyclosporin A. While the nature of the components forming the PTP remains controversial, the identification of novel inhibitors that can be used as affinity labels is offering new perspectives towards the molecular definition of the PTP

    Remote Sensing in Archaeology

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    Il volume affronta in modo lo stato dell’arte dell’applicazione delle metodologie di analisi non invasive per lo studio dei paesaggi archeologici. Se la disponibilità di immagini da satellite della superficie terrestre non costituisce una novità, il lancio nel settembre del 1999 da parte di Orbimage del satellite IKONOS, in grado di acquisire simultaneamente immagini multispettrali e pancromatiche con risoluzioni geometriche rispettivamente di quattro e un metro in formato ad 11 bit introduce prospettive inesplorate. Se è troppo presto per presentare casi di studio sui primi dati IKONOS è certamente stimolante discutere le potenzialità e i progetti che prevedono l’applicazione di questa nuova tecnologia oggetto della prima parte del volume (cfr. Donoghue; Campana, Pranzini e in particolare l’Oatland Plantation Project presentato da Victor Falimetzger). Nell’ultimo decennio importanti novità hanno interessato anche le piattaforme di ripresa aerea. Abbiamo assistito alla realizzazione di progetti pilota, basati sull’ipotesi che sensori iperspettrali (superiori a 100 canali) con risoluzioni geometriche nell’ordine di un metro/pixel, sono in grado di produrre, coadiuvati da adeguati processi elaborativi, informazioni diversamente non percepibili. Come vedremo, i dati emersi sono molto incoraggianti e mostrano un significativo incremento delle informazioni rispetto ai tradizionali sistemi di rilevamento con camere pancromatiche (cfr. Cavalli, Pignatti; Powlesland). Altri strumenti di telerilevamento quali magnetometri e ground penetrating radar (GPR), in passato utilizzati con risultati altalenanti da pochi pionieri, mostrano, come vedremo in vari interventi (cfr. Piro; Valdes in questo volume), di aver raggiunto un notevole livello di affidabilità per la valutazione dei depositi ipogei. Considerato che molto spesso la tradizionale ricognizione di superficie non è sufficiente (in particolare in aree ad alta densità di vegetazione stabile), il contributo dei sistemi di prospezione geofisica assume un ruolo di primo piano nella delicata fase di controllo a terra delle informazioni, restituendo spessore a quello che da sempre costituisce l’anello debole del processo cognitivo: la verifica sul terreno. Infine, la tecnologia di georeferenziazione satellitare satellitare (GPS) ha visto la commercializzazione di dispositivi sempre più precisi, sofisticati ed economici. Lo strumento ha assunto un ruolo centrale nel processo di rappresentazione sintetica del paesaggio e delle preesistenze antropiche. Le funzioni e le applicazioni in ambito archeologico sono molteplici, dal semplice rilievo della posizione assoluta (puntuale, lineare o areale) del record archeologico all’elaborazione, con dispositivi a lettura centimetrica, di rilievi micro topografici di superfici e strutture, per la creazione di modelli tridimensionali del terreno (cfr. Gabrielli; Forte in questo volume). Ragionando in termini inversi, la navigazione verso siti noti o ad esempio l’identificazione sul terreno di anomalie individuate con dati telerilevati diventano operazioni di routine. Oltre alle novità tecnologiche sono da rilevare recentissimi mutamenti normativi: l’auspicata abolizione del filtro a valore d’errore fluttuante introdotto dal Dipartimento della Difesa Americana per i sistemi GPS e in ambito italiano la liberalizzazione delle attività di riprese aeree sul territorio nazionale e sulle acque territoriali . Quest’ultima non deve passare inosservata, anzi è da considerare tra i cambiamenti più significativi e ricchi di ricadute immediate. A tale proposito l’intervento di Toby Driver e Chris Musson (in questo volume) costituisce una significativa base di partenza per comprendere il notevole potenziale informativo che il survey aereo fotografico obliquo con strumenti tradizionali è in grado di fornire e le modalità di gestione in ambiente GIS di dati connotati da forti peculiarità

    Genetic dissection of the permeability transition pore

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    The permeability transition pore (PTP) regulates the structural re-organization of mitochondria in response to changes in cellular Ca2+ and is thought to be an important participant in mitochondrial responses to cell death signals. Although the proteins forming the PTP have yet to be rigorously identified, recent examination of the response of mitochondria, cells and tissues lacking putative components of the PTP have been reported. Studies on mitochondria lacking cyclophilin D (CyP-D) have proved that this protein is the target for PTP inhibition by CsA; yet they have also unequivocally demonstrated that the PTP can form and open in the absence of CyP-D. Likewise, studies in mice lacking the two adenine nucleotide translocators expressed in this species have shown that a functional PTP can form in the absence of these proteins. Thus, the inner mitochondrial membrane components of the PTP remain to be identified, and the absence of CyP-D may not preclude PTP opening in vivo – a finding that questions the conclusion that the PTP participates in cell death pathways only in response to a restricted set of challenges

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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