1,355,317 research outputs found
The legacy of the École des Beaux-Arts in twentieth-century Iran: the architecture of Mohsen Foroughi
No full textThe first Iranian to graduate from the École des Beaux-Arts in Paris was Mohsen Foroughi. A leading architect and educator who played a key role in the professionalisation of architecture in Iran, Foroughi maintained his status as a respected national and international figure in the architectural discipline from the early 1960s until the Islamic Revolution of 1979. Through a focused investigation of Foroughi’s teaching and architectural works from the 1930s to the 1960s, this article foregrounds a convergence that occurred between Beaux-Arts practices and the Iranian will towards a nationalist expression. This convergence was not simply an exportation of the Beaux-Arts methods abroad; it explicitly began in the setting of the Beaux-Arts in France where such a convergence found a productive ‘testing ground’ before its eventual transfer to Iran. The article’s findings are based on archival research conducted in Paris and Tehran, and a close comparative analysis of Foroughi’s student projects at the École with his significant architectural projects in Iran. What emerges is a surprisingly subtle transformation of architectural expression from one context to the other, made possible by the particular operations of the Beaux-Arts methods within the Iranian context.Full Tex
Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases
No full textABSTRACT
Aim
This study aimed at evaluating histological features of 52 cases of calcifying odontogenic cyst (COC), which is an uncommon benign odontogenic lesion. The World Health Organization (WHO) classified COC as a neoplasm and used the term calcifying cystic odontogenic tumor (CCOT) for benign cystic type and the dentinogenic ghost cell tumor (DGCT) for the benign solid-type lesions. There is no agreement regarding COC classification.
Materials and methods
A total of 52 cases of COC were selected and reviewed from the archive of the Pathology Department of Taleghani Educational Hospital, Tehran, Iran. To better understand the pathogenesis of COC, the cases were classified.
Results
There were 52 cases (31 males and 21 females). The lesion was found in all age groups, and patients’ age from 8 to 61 years. Nineteen cases affected the maxilla, and 33 cases affected the mandible. Except two cases, all were intraosseous lesions. Radiographically, 30 cases showed a unilocular radiolucent area, and 22 cases showed a mixed radiolucent/ radiopaque region. Histopathologically, 43 cases were cystic type and 9 cases were neoplastic.
Conclusion
There are two different histopathological entities. In view of these findings, it is very difficult to determine every lesion that has a cystic architecture is truly cystic or is a neoplastic one in nature. It is believed that the solid variants may be neoplastic.
Clinical significance
A better understanding of the histological type of the lesion can provide a classification across patients. This can help in treatment planning to improve patient outcomes.
How to cite this article
Irani S, Foroughi F. Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases. J Contemp Dent Pract 2017;18(8):688-694.
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Is outstanding performance in sport events a driver of tourism?
No full textCan success in sport events be a positive determinant of the number of tourists arriving in a country where successful teams are based? In order to test this hypothesis, this paper focuses on football events linking national teams' outstanding performance in the FIFA World Cup tournaments to tourist inflows at the national level. By applying panel cointegrating regressions, the paper finds that countries whose national teams obtain surprising results (e.g. Costa Rica in 2014) in the World Cup final tournaments benefit from a significant increase in tourist arrivals after two years. In countries whose national teams qualify as football champions, the benefits appear in the first and second years following the event and the result is stronger. This suggests that outstanding performance in sport events can favor tourism and economic development in successful teams’ home countries. Policies aiming to promote national sporting teams can thus have significant effects on other sectors of the economy
A highly sensitive and selective biosensor based on nitrogen-doped graphene for non-enzymatic detection of uric acid and dopamine at biological pH value
No full textFew layered graphene nanosheets were successfully doped with nitrogen through microwave irradiation and thoroughly characterized by using electron microscopy, Raman spectroscopy and X-ray photoelectron spectroscopy. The electrochemical efficiency of N-doped graphene toward enzyme-free detection of uric acid (UA) and dopamine (DA) at neutral pH (7.4) was studied by chronoamperometry and cyclic voltammetry measurements. At working potential of +0.3 V (vs. Ag/AgCl), N-doped graphene electrode revealed ultra-high sensitivity of 2.06 mA mM−1 cm−2 and low limit of detection (LOD) of 0.13 μM within a concentration range of 0 to 0.6 mM for UA detection. Also, at very higher potential of +1.8 V (vs. Ag/AgCl), N-doped graphene sensor exhibited a highly selective response toward DA with very low LOD of 4.5 nM and high sensitivity of 7.63 mA mM−1 cm−2 in a broad linear concentration range from 0.1 to 100 μM. Furthermore, the performance of UA and DA sensors in the real blood sample was satisfactory. © 20181
Recent contributions of anatomical pathologists to the scientific literature in Australia: A bibliographic analysis
No full textBackground: Regular bibliographic analysis (BA), the detailed evaluation of scientific publications, provides meaningful information to guide research.
Aims: To provide a theme-based, longitudinal BA on recent research publications in anatomical pathology (AP) from Australia.
Methods: We conducted a retrospective BA on publications indexed in PubMed between 2012 and 2016, with at least one co-author from the departments of AP in Australia. Abstracts of all types of articles were analysed for the article theme(s), subject focus, and research design.
Results: Analysis of739 abstracts, published in 322 journals, showed that the number of publications increased dramatically, from 26 in 2012 to 269 in 2016. Pathology, the official RCPA journal, hosted most of the publications (84 articles), followed by PLoS One (23). Assessing 4,038 keywords/subjects showed that the main focuses were on genetics (163), immunohistochemistry (89), and tumour biomarkers (63). Breast (45) and lung (32) neoplasms were the most common subjects. Key study designs were retrospective (42) and cohort studies (27), with only four systematic reviews and one meta-analysis.
Discussion: This study, as the first BA in AP in Australia, provides a new overview of current research landscape. Future research can leverage upon this BA to create novel opportunities for additional research.No Full Tex
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
eQTL mapping and inherited risk enrichment analysis : a systems biology approach for coronary artery disease
No full textDespite extensive research during the last decades, coronary artery disease (CAD) remains the number one cause of death, responsible for near 50% of global mortal- ity. A main reason for this is that CAD has a complex inheritance and etiology that unlike rare single gene disorders cannot fully be understood from studies of of genes one-by-one.In parallel, studies that simultaneously assess multiple, function- ally associated genes are warranted. For this reason we undertook the Stockholm Atherosclerosis Gene Expression (STAGE) study that besides careful clinical charac- terization and genome-wide DNA genotyping also assessed the global gene expression profiles from seven CAD-relevant vascular and metabolic tissues. In paper I, we used STAGE to develop a bioinformatics tool for efficient eQTL mapping called kruX based on Kruskal-Wallis statistics test. kruX excels in de- tecting a higher proportion of nonlinear expression quantitative expression traits loci (eQTLs) compared to other established methods. This tool was developed for Python, MATLAB, and R and is available online. In paper II, we applied kruX to detect eQTLs across the seven tissues in STAGE and assessed their tissue speci- ficity. A tool for analyzing inherited risk enrichment was also developed assessing CAD association (i.e., risk enrichment) of STAGE eQTLs according to genome-wide association studies (GWAS) of CAD. We found that eQTLs active across multiple vascular and metabolic tissues are more enriched in inherited risk for CAD than tissue-specific eQTLs. In paper III, we integrate the analysis of STAGE data with data from GWAS of CAD to identify 30 regulatory-gene networks causal for CAD. In paper IV, we again used kruX to investigate STAGE eQTLs for three established candidate genes in CAD and atherosclerosis (ALOX5, ALOX5AP, and LTA4H). In addition, we used the Athero-Express dataset of genotype and atherosclerotic carotid plaque characteristics to further elucidate the role of these genes in atherosclerosis development.In sum, in this thesis report we show that by integrating GWAS with genet- ics of gene expression studies like STAGE, we can advance our understanding from the perspective of multiple genes and gene variants acting in conjunction to cause CAD in the form of regulatory gene networks. This is done through developing new bioinformatics tools and applying them to disease-specific, genetics of global gene expression studies like STAGE. These tools are necessary to go beyond our current limited single-gene understanding of complex traits, like CAD.List of scientific papersI. Jianlong Qi, Hassan Foroughi Asl, Johan Björkegren, Tom Michoel. kruX: matrix-based non-parametric eQTL discovery. BMC Bioinformatics. 2014 Jan;15:11. https://doi.org/10.1186/1471-2105-15-11 II. Hassan Foroughi Asl, Husain A Talukdar, Alida SD Kindt, Rajeev K Jain, Raili Ermel, Arno Ruusalepp, Khanh Dung H Nguyen, Radu Dobrin, Dermot F Reilly, Heribert Schunkert, Nilesh J Samani, Ingrid Brænne, Jeanette Erdmann, Olle Melander, Jianlong Qi, Torbjörn Ivert, Josefin Skogsberg, Eric E Schadt, Tom Michoel, Johan L.M. Björkegren. Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease. Circulation Cardiovascular Genetics. 2015 Apr;8(2):305-15. https://doi.org/10.1161/CIRCGENETICS.114.000640 III. Husain A. Talukdar, Hassan Foroughi Asl, Rajeev K. Jain, Raili Ermel, Arno Ruusalepp, Oscar Franzen, Brian A. Kidd, Ben Readhead, Chiara Giannarelli, Jason C. Kovacic, Torbjörn Ivert, Joel T. Dudley, Mete Civelek, Al- dons J. Lusis, Eric E. Schadt, Josefin Skogsberg, Tom Michoel,and Johan L.M. Björkegren. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease Cell Systems. 2016 March;2(3):196-208. https://doi.org/10.1016/j.cels.2016.02.002IV. Sander W vander Laan, Hassan Foroughi Asl*,Pleunie van den Borne, Jes-sica van Setten, ME Madeleine van der Perk, Sander M van de Weg, Arjan H Schoneveld, Dominique PV de Kleijn, Tom Michoel, Johan L.M. Björkegren, Hester M den Ruijter, Folkert W Asselbergs, Paul IW de Bakker, Gerard Pasterkamp. Variants in ALOX5, ALOX5AP and LTA4H are not asso- ciated with atherosclerotic plaque phenotypes: the Athero Express Genomics Study. Atherosclerosis. 2015 Apr;239(2):528-38. https://doi.org/10.1016/j.atherosclerosis.2015.01.018 </p
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