2,148 research outputs found
The Poem of Memory. "Triumphi"
No full textWriting of the "Triumphi" Fabio Finotti finds that its author undercuts a medieval idea of ascent to God in the structural progression from Love to Chastity, Death, Fame, Time, and Eternity. Here Petrarch programmatically counters Dante, transforming a universal, eschatological vision into a subjective, cultural and psychological experience
Fabio Tronchetti
No full textFabio Tronchetti is an Associate Professor of Law at the School of Law of the Harbin Institute of Technology, People’s Republic of China, where he also serves as Director of the International Law Department. Since January 2014 he works as an Adjunct Professor of Comparative National Space Law at the the School of Law of the University of Mississippi, United States. Earlier in his career he was Lecturer and Academic Coordinator at the International Institute of Air and Space Law, Leiden University, the Netherlands.
Professor Tronchetti is regularly invited to give lectures at several European and Chinese Universities, including the Cologne University (Germany), the Leiden University (the Netherlands) and the Beihang University (Beijing, China) and has participated as a speaker at numerous international conferences.
Prof. Tronchetti’s scholarly is primarily in the areas of international space law and public international law. His publications include two books and more than 20 articles in internationally peer-reviewed space law and policy journals, such as Space Policy, the German Journal of Air and Space Law, the Journal of Space Law, etc.
He holds a PhD in International Space Law (Leiden University) and an Advanced LL.M in International Relations (Bologna University, Italy). He is Member of the International Institute of Space Law (IISL), European Centre for Space Law (ECSL), and the Asian Society of International Law (ASIL). He is the recipient of the 2007 Diederiks-Verschoor award for the best paper submitted by an author not older than 40 years to the International Institute of Space Law (IISL) during the 58th International Astronautical Congress of the International Astronautical Federation (IAF).https://commons.erau.edu/stm-images/1076/thumbnail.jp
Spatio-Temporal Control of Dynamic Topographic Patterns on Azopolymers for Cell Culture Applications
No full textCell response to exogenous cues is the result of a complex integration of multiple biochemical/biophysical signals, which might occur simultaneously and might be characterized by specific spatial and temporal patterns. Among these signals, surface topography plays an important role in affecting cell functions and fate. However, the current understanding of the interplay between cells and topography relies on static environment. Here the intrinsic light-responsive properties of azopolymers and the versatility of laser-based confocal microscope technique is exploited, aiming to induce spatio-temporal dynamic topographic changes in situ during cell culture. Diverse patterns can be designed on cell-populated azopolymer films with high control on time, space, and on-off signal modification. The technique proposed in this study enables the development of synthetic platforms that finely control cell orientation and migration both in time and space. The results may pave the way to unravel complex processes involved in cell-topography interactions, thus allowing to define the spatio-temporal features that most effectively influence cell functions
Polystyrene nanoparticles affect Xenopus laevis development
No full textExposing living organisms to nanoparticulates is potentially hazardous, in particular when it takes place during embryogenesis. In this investigation, we have studied the effects of 50-nm-uncoated polystyrene nanoparticles (PSNPs) as a model to investigate the suitability of their possible future employments. We have used the standardized Frog Embryo Teratogenesis Assay-Xenopus test during the early stages of larval development of Xenopus laevis, and we have employed either contact exposure or microinjections. We found that the embryos mortality rate is dose dependent and that the survived embryos showed high percentage of malformations. They display disorders in pigmentation distribution, malformations of the head, gut and tail, edema in the anterior ventral region, and a shorter body length compared with sibling untreated embryos. Moreover, these embryos grow more slowly than the untreated embryos. Expressions of the mesoderm markers, bra (T-box Brachyury gene), myod1 (myogenic differentiation1), and of neural crest marker sox9 (sex SRY (determining region Y-box 9) transcription factor sox9), are modified. Confocal microscopy showed that the nanoparticles are localized in the cytoplasm, in the nucleus, and in the periphery of the digestive gut cells. Our data suggest that PSNPs are toxic and show a potential teratogenic effect for Xenopus larvae. We hypothesize that these effects may be due either to the amount of NPs that penetrate into the cells and/or to the "corona'' effect caused by the interaction of PSNPs with cytoplasm components. The three end-points of our study, i.e., mortality, malformations, and growth inhibition, suggest that the tests we used may be a powerful and flexible bioassay in evaluating pollutants in aquatic embryos
Per un ritratto di André Tosel
No full textIn memory of André Tosel, who passed away last March 14th in his hometown Nice, «Gramsciana» publishes an article on Gramsci in France that he had sent to this journal as a contribution to the section «My Gramsci». The editor, Fabio Frosini, prefaces the text with a quick portrait of Tosel as a philosophy professor, an influential Marxist intellectual, a critic of contemporary capitalism, as well as the author of landmark books on Spinoza, Kant and Marx and, above all, one of the most important Gramsci scholars of the last 50 years
Effetti di nanoparticelle di polistirene sull'embriogenesi di Xenopus laevis
No full textL'impiego di nanoparticelle (NP) utili per diverse applicazioni (cosmetica, abbigliamento, alimentazione e drug delivery) riscuote un vivo interesse. In medicina offrono la possibilità unica di superare la barriera cellulare per dirigere molecole verso targets specifici come le droghe utilizzate in chemioterapia. Per promuovere il giusto sviluppo di tali tecnologie è essenziale chiarire le potenziali conseguenze per la salute umana associate all???esposizione alle NP. La principale preoccupazione riguarda le loro piccole dimensioni e la possibilità che possano essere internalizzate inadeguatamente, in rapporto con le loro caratteristiche fisico-chimiche e con la natura delle cellule target (Shawna et al., 2011; Gorth et al., 2011; Pompa et al., 2011). Le NP di polistirene da noi utilizzate sono considerate materiale ???biologicamente inerte. L'impiego del sistema modello Xenopus laevis, permette di saggiare l???eventuale tossicità delle NP in vivo, valutandone gli effetti sullo sviluppo embrionale. A questo scopo sono state somministrate con due diversi protocolli: la microiniezione in uno dei blastomeri di embrioni allo stadio 2 cellule e il contatto che consiste nell'allevamento di embrioni in 1/10 Ringer contenente NP. Per entrambi i tipi di esperimenti sono state analizzate la morfologia, la percentuale di mortalità e l'espressione di alcuni marcatori embrionali quali: bra (mesoderma presuntivo), myod1 (mesoderma parassiale) e sox9 (creste neurali). Gli embrioni sia microiniettati che contatto presentano malformazioni di testa, intestino e coda, edemi variamente diffusi e mostrano, inoltre, uno sviluppo più lento. Gli embrioni microiniettati presentano un alto tasso di mortalità mentre quelli a contatto hanno un tasso di mortalità simile ai w.t. La microscopia confocale ha evidenziato la presenza di NP nell'intestino, nella faringe e nello strato esterno della retina, non nel cervello. I marcatori usati presentano tutti modificazioni dell'espressione. Questi dati suggeriscono un effetto tossico/teratogenico ma non letale delle NP per gli embrioni trattati alle condizioni precedentemente descritte
Adverse Effect of Metallic Gold and Silver Nanoparticles on Xenopus laevis Embryogenesis
No full textExposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of Xenopus laevis, an anuran amphibian key model species in toxicity testing. Through the Frog Embryo Teratogenesis Assay—Xenopus test (FETAX), we ascertained that both nanoparticles did not influence the survival rate but induced morphological anomalies like modifications of head and branchial arch cartilages, depigmentation of the dorsal area, damage to the intestinal brush border, and heart rate alteration. The expression of genes involved in the early pathways of embryo development was also modified. This study suggests that both types of nanoparticles are toxic though nonlethal, thus indicating that their use requires attention and further study to better clarify their activity in animals and, more importantly, in humans
Diagnosis and analysis as the first steps in a turnaround management process model
No full textAuthor Fabio Damm, BScDiplomarbeit Universität Linz 201
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