5,086 research outputs found
Predicting the Effects of Parameters Changes in Stochastic Models through Parallel Synthetic Experiments and Multivariate Analysis
No full textUsually researchers require many experiments to verify how biological systems respond to stimuli. However, the high cost of reagents and facilities as well as the time required to carry out experiments are sometimes the main cause of failure. In this regards, Information Technology offers a valuable help: modeling and simulation are mathematical tools to execute virtual experiments on computing devices. Through synthetic experimentation, researchers can sample the parameters space of a biological system and obtain hundreds of potential results, ready to be reused to design and conduct more targeted wet-lab experiments. A non negligible achievement of this is the enormous saving of resources and time. In this paper, we present a plug-in-based software prototype that combines high performance computing and statistics. Our framework relies on parallel computing to run large numbers of synthetic experiments. Multivariate analysis is then used to interpret and validate results. The software is tested on two well-known oscillatory models: Predator-Prey (Lotka-Volterra) and Repressilator
Introducing “La fabrique du droit”. A Conversation with Bruno Latour
No full textBruno Latour talks with Paolo Landri about his book on the Conseil d'Etat (La Fabrique du droit). The conversation was held in 2006 at the time of the Italian translation of the book and illustrates the research project and the difficulties the author had in the field. At the same time, it clarifies the trajectories of Bruno Latour's work and theoretical framework of his program of study with respect to sociology, anthropology, and philosophy of law. The conversation helps to understand the open-ended character of Bruno Latour's research and reflection including STS as well as sociological, anthropological and philosophical themes
DEVELOPMENT OF A EXPERIMENTALLY VALIDATED MODEL FOR SOLID STATE HYDROGEN STORAGE DESIGN OF MATERIAL AND TANK
No full textEDen is a European project, supported by FP7 – JTI
FCH. It aims to develop an innovative embedded system for the
storage of energy, thank to combination and thermal integration
between a SOFC (capable to work like SOE) and a innovative
solid state hydrogen storage tank. In the proposed work, the
objective is the optimization through modeling of behavior and
physical performance for hydrogen storage solution in solid-state
material (Mg-based metal hydrides). The candidate material for
hydrogen storage, and final pellet (utilized inside tank) have been
defined through the identification of best physics, to better
describe gas’ diffusion phenomena and thermal exchange inside
the storage tank
An Experimental Comparison of RISC-V Processors: Performance, Power, Area and Security - Special Session Paper
No full textThe RISC-V instruction set architecture (ISA) has garnered significant interest from both industry and academia because of its open source nature. Recent years have witnessed a surge in published implementations of the RISC-V ISA, with various companies actively pursuing its adoption in their products. However, a comprehensive analysis comparing these emerging RISC-V processors with each other and against established embedded computing platforms has not yet been published. This paper presents an experimental evaluation of three high-performance RISC-V processors: BOOM, NOEL-V, and CVA6 (formerly Ariane). The investigation is conducted on a Xilinx Kintex-7 Field-Programmable Gate Array (FPGA) platform. We perform a detailed analysis of critical performance metrics, covering area footprint, power consumption, and performance efficiency. Additionally, we assess the security posture of these cores against transient execution attacks, a prominent contemporary security threat. Finally, a comparative evaluation is undertaken between the RISC-V processors and two conventional application-level ARM processors to elucidate technological discrepancies and application suitability. This analysis aims to provide valuable insights into the current state and potential of RISC-V processors within the embedded computing domain
Lightweight Instrumentation for Accurate Performance Monitoring in RTOSes
No full textEvaluating performance metrics in embedded systems poses challenges, particularly due to the limited set of tools available for monitoring performance counters. In addition, performance evaluation frameworks for Real-Time Operating Systems (RTOSes) often lack the sophistication and capabilities available in general-purpose operating systems like Linux, which benefit from utilities such as perf_event. To bridge this gap, this paper presents an accurate and low-overhead instrumentation utility tailored for RTOSes. Our approach utilizes performance monitoring counters to observe individual user applications within the RTOS environment. Importantly, it enables comprehensive application monitoring by strategically placing probes at points of inherent system interference, thereby minimizing additional overhead. A pre-calibration of these probes allows for fine-grained measurements within user applications. This results in the elimination of 100 % of the overheads for most counters in our test configuration, impacting the context switch by only three additional instructions per monitored counter
Author Correction: Collection of the digital data from the neurological examination.
No full textIn this article, the corresponding author was inadvertently designated only to “Bruno Kusznir Vitturi” but it should have been “Bruno Kusznir Vitturi” and “Walter Maetzler”. The original article has been corrected
On Bruno Schulz’s Bookplates
No full textThe Polish version of the article was published in Roczniki Humanistyczne vol. 64, issue 1 (2016).
The article enters into a dialogue with the interpretation of Bruno Schulz’s bookplates made by Władysław Panas in his book Bruno od Mesjasza (Bruno of the Messiah) (Lublin 2001). An attempt to understand them in a different (less holistic) way leads the author of the article to the conclusion that in Schulz’s plates the first veiled variant of the mythical Book may be seen—of the fundamental motif of Bruno Schulz’s later literary work
Jordan "Bruno" Gegenhuber '16 Publishes First-Author Research
No full textJordan "Bruno" Gegenhuber '16 had first-author research, "Gene regulation by gonadal hormone receptors underlies brain sex differences," published in nature magazine on May 4, 2022.Jordan "Bruno" Gegenhuber '16 had first-author research, "Gene regulation by gonadal hormone receptors underlies brain sex differences," published in Nature magazine on May 4, 2022.
Sex hormones play a central role in shaping behavior throughout the animal kingdom, and this study maps where the receptor for estrogen binds to DNA in neurons that regulate rodent social interactions. The findings reveal that estrogen establishes lasting sex differences in gene expression and neuroanatomy during brain development, and identifies hundreds of genes that may mediate estrogen's effects on behavior and disease.
Gegenhuber earned a PhD from the Cold Springs Harbor Laboratory School of Biological Sciences in Long Island, N.Y.. in May 2022. His field of research is in neuroscience, and he has accepted a postdoctoral research position at Harvard Medical Center in Boston, Mass. He also holds the honor of being the Pacific Class of 2016 Valedictorian
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