1,720,982 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
MOLECULAR MODELLING STUDIES OF THE NF-κB BIOLOGICAL SYSTEM AS RELEVANT DRUG TARGET
No full textBackground
Virtual screening (VS) is now a well-established method for finding small molecular modulators of
a biological relevant macromolecule function by using much older computational techniques, such
as docking simulations. The NF-kB family consists of a group of eukaryotic inducible transcription
factors that have evoked widespread interest until now. As a matter of fact, the dysfunction of NF-kB is associated with many serious disease states. In spite of the well-defined solved NF-kB 3D
structures, to the best of our knowledge, nowadays VS applications against this interesting target for
the discovery of new NF-kB/DNA inhibitors have not been published yet.
Aims
The project described in this thesis is aimed to the identification of low molecular weight
compounds interacting with NF-kB and able to inhibit DNA/NF-kB complex formation and
biological dependent functions.
Methods
As a first example towards the development of a docking protocol fit to the target under study (NF-kB
p50 monomer and homodimer), a data set of 27 bioactive natural compounds were prepared. In
the second example a chemical library was purpose-made for VS applying a filtering procedure on
3D ZINC commercial database containing more than 2 million compounds. Successively a focus
furocoumarin library of 1700 molecules was prepared for subsequent docking runs. The three
dimensional structure of the complex NF-kB-DNA was retrieved from the RCSB Protein Data
Bank. The cocrystallized DNA macromolecule was removed from the structure. p50-p50
homodimer, p50-p65 heteodimer and p50 monomers were selected for the docking simulations and
prepared using the graphical interface Maestro. All molecules under study were docked in to the
binding site of the target using Glide software from Schrodinger. Grids were prepared for each
proteins. The coordinates of the enclosing box were defined starting from the set of active site
residues involved in hydrogen bonds with the NF-kB recognition site of DNA and optimised
including the double strands DNA helices volume by visual inspection.
Docking studies were based on rigid X-ray crystal transcription factor structures (1LE9, 1IKN) and
no information is reported in literature on dynamic features of this protein. Thus, 14ns of canonical
MD simulations were carried out in explicit solvent on structural models of NF-kB systems as free
and bound both to DNA and IkB. CHARMM27 force field, TIP3P model for water and P.M.E. for
electrostatic force calculation were used.
Main Results
We found that the adopted docking sampling method and the scoring function were successful in
predict the ranking of active and inactive natural compounds into DNA binding site of the ensemble
protein (NF-kB p50). Further EMSA assays and biological evaluation were in agreement with
computational findings.
A successful identification of a micromolar active compound from docking-based VS of the
prepared compound library is described. Subsequent in silico screening of the developed focus
furocoumarin library carried forward the identifications of five micromolar p50 binders. The
binding modes of the best-scored compounds showed the involvement of an essential residue for
p50 in vivo activity in DNA interaction. In depth investigations of these interesting hits are also
reported, including docking analysis into p50-p65 heterodimer. The ligands showed a different
occupation of the DNA binding region of the heterodimer.
The structural and dynamics properties of NF-kB p50-p65 in free form and in complex with DNA
and IkB have been analyzed showing quite pertinent differences. The most relevant configurations
of the transcription factor have been clustered and selected for further docking studies and drug
design.
Conclusions
Discovered micromolar bioactive compounds can be considered as “leads” for developing stronger
NF-kB/DNA inhibitors. The encouraging computational and biological results here reported could
open new perspectives in discovery of NF-kB/DNA interaction inhibitors by taking advantages
from recent VS strategies
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
- …
