100,361 research outputs found
Numerical investigation into the structure of scalar plumes in a simple room
No full textIndoor airflow can be complex due to large regions with no dominant flow direction and low velocities. An airborne material released from a surface indoors would be expected to result in a high degree of variability inconcentration. It is currently not known how the spatially and temporally resolved concentration field from this type of source could be exploited for the detection of contaminants or vapour from concealed materials. Previous experimental and numerical work has provided information on flow and passive scalar transport in indoor environments but little on how different detection/search strategies could be employed in these environments. This work used large-eddy simulation to extensively study the turbulence fluctuations and the instantaneous vapour field in a widely studied, iso-thermal, benchmark test room, considering the effects of the source size and location. The work provides insight into vapour behaviour within indoor spaces and can have application to fields such as vapour detection, source localisation using autonomous systems, or exposure to toxic chemicals. As an example, we have interpreted the results in terms of current theories of chemical location by animals and the capability of detection dogs
Experimental investigation of scalar dispersion in indoor spaces
No full textThe scalar dispersion from point sources in indoor spaces is experimentally investigated using simultaneous particle–image velocimetry and planar laser-induced fluorescence techniques in a 20:1 and a 60:1 full-to-model scale room model. The ventilation inlets dominate turbulence production, with magnitudes of the velocities and Reynolds stresses observed to increase with air changes per hour (ACH). Mean concentration maps show a dependence on the ACH and source location which is attributed to the flow field at the near-source region. The peak-to-mean concentration shows a weak dependence on the mean concentration and concentration variance maps, indicating risk for toxic chemicals may be underpredicted if based only on these information. The concentration PDFs are generally well-described by exponential distributions with C
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rms
′ values never exceeding 5.0. The magnitudes of the advective and turbulent scalar fluxes are strongly dependent on the ACH and source location, neither of which are able to dominate the other by more than an order of magnitude. The eddy diffusivity tensor was measured and a conditional-averaging based method is proposed to approximate it to an isotropic eddy diffusion coefficient, K. For real applications where K is used to estimate magnitudes of the turbulent scalar flux using the gradient transport model, the assumption of isotropic turbulence can introduce an uncertainty of around 17.8%.</p
On the effects of walking speed, crowd density and human-to-source distance on pollutant dispersion in indoor spaces
No full textThe effects of walking speed, crowd density and human-to-source distance on pollutant dispersion in two scaled room models are investigated using simultaneous planar laser-induced fluorescence and particle-image velocimetry techniques. For a small 3 m high room, where the length-scales of the people and room are comparable, the walking motions significantly influenced the macro room mean flow patterns. This has a strong effect on the scalar dispersion properties as the magnitudes of the advective scalar fluxes are often comparable or larger than the turbulent scalar fluxes. As such, the scalar dispersion properties are case specific. For a large 9 m high room, the walking motion influenced only the local mean flow field. The increase in walking speed and crowd density improves the efficiency in which the scalar is transported and mixed with fresh ambient fluid out of the measurement plane (i.e. along the direction of the motion), leading to scalar-free zones observed on the opposite side of the room from the ventilation outlet. The area of the scalar-free zone increases with an increase in the walking speed and crowd density. The advective scalar fluxes are more sensitive to the human motion than the turbulent components, and as the mixing efficiency improves, the advective fluxes show a greater weakening with increased distance from source. The concentration PDFs in the near-source region can be described by the exponential function where the expected value at the 99% percentile can be derived as C
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rms
′=4.61, which agreed well with the experimental measurements of 4.1 to 5.9.</p
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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