1,721,117 research outputs found
The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels
Full text linkHydrocortisone inhibits prostaglandin generation by rat peritoneal leucocytes by releasing the polypeptide phospholipase inhibitor, macrocortin. The susceptibility of these cells to hydrocortisone is directly correlated with their intracellular macrocortin content. Cells depleted of the peptide by prior incubation with steroid cannot respond to the steroid, until a fresh intracellular store has been synthesized. In vitro, this process requires 4-5 h. Cells remain sensitive to the inhibitory action of the peptide at all times
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
No full textAnalysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment
No full textThe Natural History Museum 1999 meeting on the biodiversity of Lake Baikal and a workshop on the taxonomy of Lake Baikal diatoms: the combined reports
Full text linkThe main aim of this two day meeting was to foster collaboration between biodiversity specialists from western countries and from Russia who share a common interest in biodiversity issues concerning Lake Baikal. The meeting will hopefully stimulate discussion and debate that will facilitate future joint international research interest on the impressive diversity displayed by the biota of this great lake
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis
Full text linkAbstract Background The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of endogenous anti-inflammation, affording regulation of leukocyte trafficking and activation in many contexts, yet its role in lung pathologies has been scarcely investigated, despite being highly expressed in lung cells. Here we have applied the bleomycin lung fibrosis model to AnxA1 null mice over a 21-day time-course, to monitor potential impact of this mediator on the control of the inflammatory and fibrotic phases. Results Analyses in wild-type mice revealed strict spatial and temporal regulation of the Anxa1 gene, e.g. up-regulation in epithelial cells and infiltrated granulocytes at day 7, followed by augmented protein levels in alveolar macrophages by day 21. Absence of AnxA1 caused increases in: i) the degree of inflammation at day 7; and ii) indexes of fibrosis (assessed by deposition of hydroxyproline in the lung) at day 7 and 21. These alterations in AnxA1 null mice were paralleled by augmented TGF-β1, IFN-γ and TNF-α generation compared to wild-type mice. Finally, treatment of wild type animals with an AnxA1 peptido-mimetic, given prophylactically (from day 0 to 21) or therapeutically (from day 14 onward), ameliorated both signs of inflammation and fibrosis. Conclusion Collectively these data reveal a pathophysiological relevance for endogenous AnxA1 in lung inflammation and, more importantly, fibrosis, and may open new insights for the pharmacological treatment of lung fibrosis.</p
Lipocortin 1 reduces myocardial ischaemia-reperfusion injury by affecting local leukocytes recruitment
No full textEvidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
No full textGlucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands.
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