1,721,092 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
SMARCC1 controls oncogenic NOTCH1 signaling in T-cell acute lymphoblastic leukemia
No full textT cell development and differentiation are tightly regulated through a complex interplay of external signals and conserved signal-directed regulatory networks governing transcriptional programs that enable precise differentiation of precursors into mature CD4+ or CD8+ SP T cells. Dysregulation of these processes can lead to differentiation arrest and leukemic transformation of T cells. Activating mutations in NOTCH1 are highly prevalent in T-ALL and aberrant NOTCH1 signaling is required for maintenance of the leukemogenic state in T-cell progenitors. However, little is known about which interaction partners are essential for oncogenic NOTCH1 signaling and the maintenance of the differentiation blockade. We therefore aimed to identify previously unappreciated molecular dependencies required for NOTCH1-driven T-ALL. To systematically probe members of the NOTCH1-interactome for functionality in maintaining the oncogenic state, we performed an in vitro miR-E-based loss-of-function RNAi screen employing an shRNA-library targeting 340 genes of the NOTCH1-interactome in a murine model of human intracellular NOTCH1-induced T-ALL (Tx17 cell line). To elucidate NOTCH1-specific depletors, the screen was also performed in two murine NOTCH1-negative cell lines, the pro-B-cell line Ba/F3 and the T-cell lymphoma cell line EL4. Using our screening platform, we uncovered SMARCC1, a core member of the SWI/SNF nucleosome remodeling complex, as essential for maintaining NOTCH1-driven T-ALL. We identified that Smarcc1 knockdown in Tx17 cells resulted in a rapid and strong depletion of shRNA-expressing cells. These results were confirmed in the NOTCH1-dependent human T-ALL cell line Jurkat and by probing public data from the depmap portal, revealing a strong SMARCC1-dependency in the two most NOTCH1-dependent cell lines tested, Jurkat and PF-382. Pulldown of human SMARCC1 in Tx17 cells and proteomic analysis revealed binding of most SWI/SNF complex subunits and NOTCH1. Retransplantation of Tx17 cells harboring shSmarcc1 or neutral shRNAs and in vivo shRNA induction led to a significantly decreased spleen infiltration of Tx17 cells transduced with the shSmarcc1 compared to a neutral shRNA. RNA-seq analysis of Smarcc1 depleted cells indicated a differentiation switch from DP to CD4+ SP cells, implicating SMARCC1 as a mediator of NOTCH1-induced differentiation blockade. Collectively, we identified SMARCC1 as a major contributor to oncogenic NOTCH1 signaling and maintenance of the immature differentiation state in T-ALL
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
