293 research outputs found
Condizione ecologica diRuditapes decussatus(Veneridae) e sua presenza in aree di raccolta nel Golfo di Olbia = Ecological status and occurrence ofRuditapes decussatus(Veneridae) in harvested sites within the Gulf of Olbia
No full textA pilot study was performed in order to evaluate the ecological status of the clamRuditapes decussatusand its occurrence in specific harvested areas within the Gulf of Olbia. Indeed, since 1998, stocks of this clam seems to be decreased, due to intense human harvesting
Good Masters: A Reply to Massimo Fusillo, Daniele Scalise, Filippo La Porta and Gianluigi Rossini
No full textA final comment given by Pierpaolo Antonello, author of Dimenticare Pasolini
Effetto del rapporto foraggi/concentrati della razione su alcuni parametri endocrino-metabolici nel sangue di pecore a fine lattazione
No full textEffetti endocrino-metabolici di razioni a differente rapporto F:C in pecore da latte nella fase intermedia di lattazione
No full textEffects of dietary NDF concentration on milk yield, bacterial protein syntheses and endocrine-metabolic status in dairy sheep in late laxtation
No full textMODIFICAZIONI MICROTUBULARI OSSIDATIVO-INDOTTE IN UNA LINEA DI CELLULE DI SCHWANNOMA DI RATTO SOTTOPOSTE A CONDIZIONI DI IPERGLICEMIA SPERIMENTALE
No full textThe neuropathies of the peripheral and central nervous systems can be caused by hyper -glycemia, a consequence of the deregulation of glucose, resulting in an increase in reactive
oxygen species, with subsequent cellular lesions and impairment of cytoskeletal components
(Maritim et al. 2003; Allen et al. 2005; Drel et al. 2006; Gadau et al., 2009). Microtubules, one
component of the cytoskeleton, are composed of heterodimers of α- and α-tubulin, mainly
α-tubulin, may receives diverse post-translational modifications, consisting in tyrosination,
detyrosination, acetylation, nitrotyrosination, polyglycylation, polyglutamylation, phosphori -lation, palmytoylation (Westermann and Weber, 2003; Fukushima et al., 2009). in the present
work attention has been paid on the possible nitrosative effect of high glucose conditions on
microtubular network in a rat shwannoma cell line. Cells incubated for 72hrs in the presen-ce of 180 mM D-glucose revealed alterations in cell morphology, growth rate and catalase
activity in comparison with controls. in addition, an increase in acetylated α-tubulin and ni -trotyrosine and a downregulation of total, tyrosinated and detyrosinated α-tubulin was found
with Western blot analysis and immunofluorescence. no significant changes in other cytoske -letal components such as actin and GFAP was seen. our work underlined that high glucose
can selectively affects microtubular network in schwannoma cells, exerting its detrimental
effect either through a nitrosylation of tubulin or through the possible inhibition of deacetyla -se enzymes, with subsequent impairment of microtubular functionality
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