2,728 research outputs found
Wie können wir klimaneutral werden? - Netzwerke als Innovationstreiber
No full textKooperation und vorwettbewerblicher Austausch erleichtern notwendige Transformationen von Unternehmen auf dem Weg zur Klimaneutralität. Wie das Fraunhofer-Netzwerk »Klimaneutrale Unternehmen« als Innovationstreiber wirkt, erläutern Dr. Anna-Lena Klingler und Dr. Florian Herrmann vom Fraunhofer IAO
Faculty Spotlight 2008-09 Richard Herrmann
No full textMershon Center for International Security Studies Faculty Spotlight 2008-09The University Archives has determined that this item is of continuing value to OSU's history.Richard Herrmann is director of the Mershon Center for International
Security Studies. Since 2002, he has led the center's efforts to attract a
world-class faculty, establish its reputation as a leader in security studies,
and offer special opportunities to enhance the student experience.
Herrmann specializes in international relations, security and conflict
studies, political psychology, and politics in the Middle East and Russia.
He has written on the role of perception and imagery in foreign policy and
the importance of nationalism and identity politics. He is the author or
editor of three books and more than 40 articles in such journals as
American Political Science Review, International Organization,
International Security, and World Politics
Florian Herrmann, Strategien der Todesdarstellung in der Markuspassion. Ein literaturgeschichtlicher Vergleich, (Novum Testamentum et Orbis Antiquus – Studien zur Umwelt des Neuen Testaments, 86), Göttingen, Vandenhoeck & Ruprecht, 2010
No full textGrappe Christian. Florian Herrmann, Strategien der Todesdarstellung in der Markuspassion. Ein literaturgeschichtlicher Vergleich, (Novum Testamentum et Orbis Antiquus – Studien zur Umwelt des Neuen Testaments, 86), Göttingen, Vandenhoeck & Ruprecht, 2010. In: Revue d'histoire et de philosophie religieuses, 91e année n°3, Juillet-Septembre 2011. pp. 449-450
Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins
No full textAbstract Single‐walled carbon nanotubes (SWCNTs) are a 1D nanomaterial that shows fluorescence in the near‐infrared (NIR, \u0026gt;800 nm). In the past, covalent chemistry was less explored to functionalize SWCNTs as it impairs NIR emission. However, certain sp3 defects (quantum defects) in the carbon lattice have emerged that preserve NIR fluorescence and even introduce a new, red‐shifted emission peak. Here, we report on quantum defects, introduced using light‐driven diazonium chemistry, that serve as anchor points for peptides and proteins. We show that maleimide anchors allow conjugation of cysteine‐containing proteins such as a GFP‐binding nanobody. In addition, an Fmoc‐protected phenylalanine defect serves as a starting point for conjugation of visible fluorophores to create multicolor SWCNTs and in situ peptide synthesis directly on the nanotube. Therefore, these quantum defects are a versatile platform to tailor both the nanotube's photophysical properties as well as their surface chemistry.Two new quantum defects were incorporated into single‐walled carbon nanotubes (SWCNT) carrying anchor groups for functionalization with biomolecules. The potential and versatility of this approach was demonstrated by the conjugation of a GFP‐binding nanobody as well as the growth of (fluorescent) peptide chains directly on the nanotube's carbon lattice. imageVolkswagen Foundation (DE)Niedersächsisches Ministerium für Wissenschaft und Kultur http://dx.doi.org/10.13039/50110001057
Tuning Selectivity of Fluorescent Carbon Nanotube-Based Neurotransmitter Sensors
No full textDetection of neurotransmitters is an analytical challenge and essential to understand neuronal networks in the brain and associated diseases. However, most methods do not provide sufficient spatial, temporal, or chemical resolution. Near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) have been used as building blocks for sensors/probes that detect catecholamine neurotransmitters, including dopamine. This approach provides a high spatial and temporal resolution, but it is not understood if these sensors are able to distinguish dopamine from similar catecholamine neurotransmitters, such as epinephrine or norepinephrine. In this work, the organic phase (DNA sequence) around SWCNTs was varied to create sensors with different selectivity and sensitivity for catecholamine neurotransmitters. Most DNA-functionalized SWCNTs responded to catecholamine neurotransmitters, but both dissociation constants (Kd) and limits of detection were highly dependent on functionalization (sequence). Kd values span a range of 2.3 nM (SWCNT-(GC)15 + norepinephrine) to 9.4 μM (SWCNT-(AT)15 + dopamine) and limits of detection are mostly in the single-digit nM regime. Additionally, sensors of different SWCNT chirality show different fluorescence increases. Moreover, certain sensors (e.g., SWCNT-(GT)10) distinguish between different catecholamines, such as dopamine and norepinephrine at low concentrations (50 nM). These results show that SWCNTs functionalized with certain DNA sequences are able to discriminate between catecholamine neurotransmitters or to detect them in the presence of interfering substances of similar structure. Such sensors will be useful to measure and study neurotransmitter signaling in complex biological settings
Quantendefekte als Werkzeugkasten für die kovalente Funktionalisierung von Kohlenstoffnanoröhren mit Peptiden und Proteinen
No full textVolkswagen Foundation (DE)Niedersächsisches Ministerium für Wissenschaft und Kultur http://dx.doi.org/10.13039/50110001057
Quantum defects as versatile anchors for carbon nanotube functionalization
No full textS.727-747Single-wall carbon nanotubes (SWCNTs) are used in diverse applications that require chemical tailoring of the SWCNT surface, including optical sensing, imaging, targeted drug delivery and single-photon generation. SWCNTs have been noncovalently modified with (bio)polymers to preserve their intrinsic near-infrared fluorescence. However, demanding applications (e.g., requiring stability in biological fluids) would benefit from a stable covalent linkage between the SWCNT and the functional unit (e.g., antibody, fluorophore, drug). Here we present how to use diazonium salt chemistry to introduce sp3 quantum defects in the SWCNT carbon lattice to serve as handles for conjugation while preserving near-infrared fluorescence. In this protocol, we describe the straightforward, stable (covalent), highly versatile and scalable functionalization of SWCNTs with biomolecules such as peptides and proteins to yield near-infrared fluorescent SWCNT bioconjugates. We provide a step-by-step procedure covering SWCNT dispersion, quantum defect incorporation, bioconjugation, in situ peptide synthesis on SWCNTs, and characterization, which can be completed in 5-7 d.17Nr.
Quantum Defects As a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins
No full textHenri Temianka Correspondence; (herrmann)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/3597/thumbnail.jp
Henri Temianka Correspondence; (herrmann)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/3594/thumbnail.jp
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