16,837 research outputs found
Bifunctional silk nanospheres for targeted delivery of oligonucleotide therapeutics to VEGFR-positive cells in the tumor microenvironment
No full textThis dataset contains experimental data supporting the publication “Bifunctional silk nanospheres for targeted delivery of oligonucleotide therapeutics to VEGFR-positive cells in the tumor microenvironment.” The study was conducted as part of a research project funded by the National Science Centre (grant no. 2021/43/D/NZ7/00622).The purpose of the study was to develop and evaluate a targeted drug delivery system based on functionalized silk nanospheres for the selective delivery of oligonucleotide therapeutics to vascular endothelial growth factor receptor (VEGFR)-overexpressing cells in the tumor microenvironment.The dataset includes data generated during the engineering and characterization of five hybrid silk proteins produced by fusing bioengineered MS1 silk with peptides targeting VEGFR-1 (VE1MS1, VE1bMS1, VE1cMS1) and VEGFR-2 (VE2bMS1, VE2cMS1). These constructs were assessed for receptor binding and cellular internalization in VEGFR-overexpressing cells, resulting in the selection of VE1MS1 and VE2bMS1 as lead candidates for drug delivery system development.Further data document the formation of bifunctional silk nanospheres obtained by blending VE1MS1 or VE2bMS1 with the nucleic acid–binding silk protein MS2KN. The dataset covers nanoparticle physicochemical characterization, nucleic acid-binding capacity, cytotoxicity, cellular uptake, selective interaction with VEGFR-overexpressing non-small-cell lung cancer cells, and therapeutic efficacy, including siRNA-mediated gene silencing.The dataset provides comprehensive experimental evidence demonstrating that incorporation of VEGFR-targeting enhances receptor-specific cellular interactions, and, in combination with MS2KN, enables efficient and targeted delivery of siRNA therapeutics to the VEGFR-overexpressing cells of the tumor microenvironment.</p
Where is my party now? New data on media coverage of parties’ ideological positions before elections
No full textAn Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
Get PDFAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Selection of work by Anna Gerber
Get PDFVarious journals and magazines Anna Gerber has contributed to. Anna Gerber is a graphic designer and writer based in London.
She is the author and designer of All Messed Up: Unpredictable Graphics (Laurence King, 2004) and co-editor and co-designer
of Influences: A Lexicon of Contemporary Graphic Design (Die Gestalten Verlag, 2006) with Anja Lutz. She writes regularily for magazines such as Print, Eye, Creative Review, Varoom and Idea Magazine and her work has also been published in shift!, dot dot dot and +rosebud.
She teaches at the London College of Communication on the BA Graphic Design and MA Design Writing Criticism programmes. She has also held workshops and lectures across the U.K. (including Tate Modern and the V&A Museum), as well as in India, the U.S., Australia and Malaysia.
Anna Gerber is currently engaged in research and developing projects relating to sustainability and how it applies to graphic
design as well as exploring contemporary graphic design in India
10.1177_1358863X18811596_Supplementary_material_table4 – Supplemental material for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study
No full textSupplemental material, 10.1177_1358863X18811596_Supplementary_material_table4 for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study by Paulina Talarowska, Piotr Dobrowolski, Anna Klisiewicz, Anna Kostera-Pruszczyk, Anna Członkowska, Iwona Kurkowska-Jastrzębska, Dariusz Gąsecki, Ewa Warchoł-Celińska, Łukasz Światłowski, Elżbieta Florczak, Magdalena Januszewicz, Ilona Michałowska, Katarzyna Józwik-Plebanek, Piotr Szczudlik, Beata Błażejewska-Hyżorek, Marcin Protasiewicz, Piotr Odrowąż-Pieniążek, Łukasz Tekieli, Katarzyna Michel-Rowicka, Katarzyna Hanus, Krystyna Widecka, Marta Sołtysiak, Andrzej Tykarski, Łukasz Stryczyński, Małgorzata Szczerbo-Trojanowska, Piotr Hoffman, Aleksander Prejbisz and Andrzej Januszewicz in Vascular Medicine</p
10.1177_1358863X18811596_Supplementary_material_table1 – Supplemental material for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study
No full textSupplemental material, 10.1177_1358863X18811596_Supplementary_material_table1 for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study by Paulina Talarowska, Piotr Dobrowolski, Anna Klisiewicz, Anna Kostera-Pruszczyk, Anna Członkowska, Iwona Kurkowska-Jastrzębska, Dariusz Gąsecki, Ewa Warchoł-Celińska, Łukasz Światłowski, Elżbieta Florczak, Magdalena Januszewicz, Ilona Michałowska, Katarzyna Józwik-Plebanek, Piotr Szczudlik, Beata Błażejewska-Hyżorek, Marcin Protasiewicz, Piotr Odrowąż-Pieniążek, Łukasz Tekieli, Katarzyna Michel-Rowicka, Katarzyna Hanus, Krystyna Widecka, Marta Sołtysiak, Andrzej Tykarski, Łukasz Stryczyński, Małgorzata Szczerbo-Trojanowska, Piotr Hoffman, Aleksander Prejbisz and Andrzej Januszewicz in Vascular Medicine</p
10.1177_1358863X18811596_Supplementary_material_table2 – Supplemental material for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study
No full textSupplemental material, 10.1177_1358863X18811596_Supplementary_material_table2 for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study by Paulina Talarowska, Piotr Dobrowolski, Anna Klisiewicz, Anna Kostera-Pruszczyk, Anna Członkowska, Iwona Kurkowska-Jastrzębska, Dariusz Gąsecki, Ewa Warchoł-Celińska, Łukasz Światłowski, Elżbieta Florczak, Magdalena Januszewicz, Ilona Michałowska, Katarzyna Józwik-Plebanek, Piotr Szczudlik, Beata Błażejewska-Hyżorek, Marcin Protasiewicz, Piotr Odrowąż-Pieniążek, Łukasz Tekieli, Katarzyna Michel-Rowicka, Katarzyna Hanus, Krystyna Widecka, Marta Sołtysiak, Andrzej Tykarski, Łukasz Stryczyński, Małgorzata Szczerbo-Trojanowska, Piotr Hoffman, Aleksander Prejbisz and Andrzej Januszewicz in Vascular Medicine</p
10.1177_1358863X18811596_Supplementary_material_table3 – Supplemental material for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study
No full textSupplemental material, 10.1177_1358863X18811596_Supplementary_material_table3 for High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: The ARCADIA-POL study by Paulina Talarowska, Piotr Dobrowolski, Anna Klisiewicz, Anna Kostera-Pruszczyk, Anna Członkowska, Iwona Kurkowska-Jastrzębska, Dariusz Gąsecki, Ewa Warchoł-Celińska, Łukasz Światłowski, Elżbieta Florczak, Magdalena Januszewicz, Ilona Michałowska, Katarzyna Józwik-Plebanek, Piotr Szczudlik, Beata Błażejewska-Hyżorek, Marcin Protasiewicz, Piotr Odrowąż-Pieniążek, Łukasz Tekieli, Katarzyna Michel-Rowicka, Katarzyna Hanus, Krystyna Widecka, Marta Sołtysiak, Andrzej Tykarski, Łukasz Stryczyński, Małgorzata Szczerbo-Trojanowska, Piotr Hoffman, Aleksander Prejbisz and Andrzej Januszewicz in Vascular Medicine</p
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