8 research outputs found
Correction: Muniz-Santos et al. The Influence of Competition Day Loads on the Metabolic and Immune Response of Olympic Female Beach Volleyball Athletes: A Sportomics Analysis. Nutrients 2025, 17, 1924
No full textFlavio Bachini was not included as an author in the original publication [...
Exercício de intensidade moderada associado à dieta cetogênica: Um modelo de estudo para o metabolismo de amônia?
No full textIntrodução: O exercício tem sido utilizado como modelo para compreender a produção de amônia (NH3 + NH4+) um metabólito tóxico para o sistema nervoso central. A dieta cetogênica é caracterizada pela redução no consumo de carboidratos levando modificações metabólicas para manutenção da relação ATP/ADP, que incluem a diminuição da reserva de glicogênio, o uso de aminoácidos como fornecedores de esqueletos de carbono e aumento da b-oxidação de ácidos graxos. A produção de amônia durante o exercício de alta intensidade é um evento bastante estudado, porém pouco se conhece deste metabolismo em exercício de intensidade moderada. Neste estudo investigamos o metabolismo de amônia durante o exercício de intensidade moderada e longa duração associado à dieta cetogênica como indutores de estresse metabólico. Materiais e Métodos: Os atletas (n=7) foram avaliados segundo diversos parâmetros clínicos e tiveram seu consumo máximo de oxigênio (VO2máx) e freqüência cardíaca máxima (FCmáx) individualmente estimados. Os sujeitos permaneceram em dieta cetogênica nas 72h prévias ao experimento que aconteceu com intensidade de 60% da potência desenvolvida no VO2máx e 70%-75% da FCmáx durante 60min. Resultados: Houve aumento de 35% da amonemia basal em resposta a dieta cetogênica. O exercício causou elevação de 250% na amonemia, coerentemente a uremia basal se elevou 60% devido à dieta cetogênica, sem mudanças em resposta ao exercício. O urato sérico basal se elevou 10% sem ser modificado pelo exercício. Não detectamos mudanças na glicemia ou lactatemia durante qualquer fase do estudo. Discussão: Nossos achados parecem indicar que o exercício de intensidade moderada associado à dieta cetogênica pode ser usado como modelo para elevação da amonemia, possibilitando o seu uso como indutor de estresse metabólico para o estudo do metabolismo de amônia
Physical capacities and combat performance characteristics of male and female Olympic boxers
No full textPurpose: The study characterized the anthropometrical and cardiorespiratory profile, and the cardiorespiratory, bio-chemical and immunological responses to 3 × 3 min round (R) free-contact/combat boxing simulation, in elite Olympic Boxers (4 female and 10 male).
Methods: The evaluation consisted of resting metabolic rate, anthropometric measurement, maximal graded test exercise (visit 1), free combat simulation (3 × 3 min R, 1 minute rest), and blood samples collected before, during and after the combat (visit 2).
Results: Respectively, females and males had (mean±SD; or median: for non-parametric data) body fat percentage (17.2[3.5] and 4.6[0.8]%), predominantly mesomorphic somatotyping, and (Formula presented.) (50.0 ± 2.5 and 56.2 ± 5.2 ml.kg−1.min−1). The free combat simulation resulted in high cardiovascular strain [mean heart rate corresponding to R1: 92 ± 3; R2: 94 ± 2; and R3: 95 ± 2% of maximal HR] and blood chemistry indicative of acidosis (following R3: 7.21 ± 0.08 pH, bicarbonate 13.1 ± 3.6 mmol.L−1, carbon dioxide 13.9 ± 3.8 mmol.L−1, lactate 15.1 ± 3.8 mmol.L−1, and glucose 8.4 ± 1.3 mmol.L−1). Further, notable general catabolism, hematological and immune responses were evident post combat simulation (1-hour post R3: creatinine 95.2 ± 14.5 µmol.L−1, urea 6.4 ± 1.3 mmol.L−1, white blood cell accumulation 7.8 ± 2.6 × 109.L−1, hemoglobin 14.9 ± 0.8 g.dL−1 and hematocrit 43.7 ± 1.9%).
Conclusions: Notable cardiovascular strain and acidosis are seen from the 3 × 3 free combat simulation whilst pronounced catabolism and immune responses are evident 1-hour post R3. This characterization is the first in male and female (who recently adopted the 3 × 3 min R format, as used by males) elite Olympic boxers and provides a characterization framework to assist practitioners and athletes in their attempts to deliver evidence-informed practice for specific conditioning session design.</p
Creatine and creatinine quantification in Olympic athletes: dried blood spot analysis pilot study
No full textCapillary dried blood spot (DBS) samples facilitate field-based collection without venipuncture. This pilot study aims to evaluate the viability of creatine (Cr) and creatinine (Crt) quantification using fresh capillary serum (CrS/CrtS) and DBS samples (CrDBS/CrtDBS), using Flow Injection Analysis Mass Spectrometry (FIA – MS). Nine Olympic Athletes provided a capillary blood sample to assess CrS/CrtS and CrDBS/CrtDBS quantified by FIA – MS. No difference between CrtS (mean ± SD: 813.6 ± 102.4 µmol/L) and CrtDBS (812.4 ± 108.1 µmol/L) was observed with acceptable variance [SEM 88.7; CV 10.7%; ICC 0.57 (CI 95% 0.06 – 0.84)] and agreement [very strong (Spearman: r = 0.77; p S (mean ± SD: 691.8 ± 165.2 µmol/L) was significantly different to CrDBS (2911 ± 571.4 µmol/L) with unacceptable variance [SEM 171.6; CV 27%; ICC 0.002 (CI 95% -0.02 – 0.07)] and ‘weak’ agreement [Spearman: r = 0.21, p = 0.47 and Pearson: r = 0.06, p = 0.84; Bland Altman lower (-3367) and upper (-1072) limits of agreement]. Crt quantification is viable using both CrtS and CrtDBS (but not for Cr and CrS/CrDBS), with the DBS tissue handling technique offering several methodological and practice facing advantages. Future work should expand upon the sample size, explore sport/discipline relevant analytes across a full competitive season, including key training, recovery and performance blocks of their periodized performance plan.</p
Creatine and creatinine quantification in olympic athletes: dried blood spot analysis pilot study
No full textCapillary dried blood spot (DBS) samples facilitate field-based collection without venipuncture. This pilot study aims to evaluate the viability of creatine (Cr) and creatinine (Crt) quantification using fresh capillary serum (Cr(S)/Crt(S)) and DBS samples (Cr(DBS)/Crt(DBS)), using Flow Injection Analysis Mass Spectrometry (FIA – MS). Nine Olympic Athletes provided a capillary blood sample to assess Cr(S)/Crt(S) and Cr(DBS)/Crt(DBS) quantified by FIA – MS. No difference between Crt(S) (mean ± SD: 813.6 ± 102.4 μmol/L) and Crt(DBS) (812.4 ± 108.1 μmol/L) was observed with acceptable variance [SEM 88.7; CV 10.7%; ICC 0.57 (CI 95% 0.06 – 0.84)] and agreement [very strong (Spearman: r = 0.77; p < 0.01) or strong (Pearson: r = 0.56; p = 0.04); Bland Altman: lower (-193) and upper (+196) limits of agreement]. Cr(S) (mean ± SD: 691.8 ± 165.2 μmol/L) was significantly different to Cr(DBS) (2911 ± 571.4 μmol/L) with unacceptable variance [SEM 171.6; CV 27%; ICC 0.002 (CI 95% -0.02 – 0.07)] and ‘weak’ agreement [Spearman: r = 0.21, p = 0.47 and Pearson: r = 0.06, p = 0.84; Bland Altman lower (-3367) and upper (-1072) limits of agreement]. Crt quantification is viable using both Crt(S) and Crt(DBS) (but not for Cr and Cr(S)/Cr(DBS)), with the DBS tissue handling technique offering several methodological and practice facing advantages. Future work should expand upon the sample size, explore sport/discipline relevant analytes across a full competitive season, including key training, recovery and performance blocks of their periodized performance plan
The Influence of Competition Day Loads on the Metabolic and Immune Response of Olympic Female Beach Volleyball Athletes: A Sportomics Analysis
No full textBackground: Beach volleyball (BVb) is a highly demanding Olympic sport characterized by intense physical activity and unique environmental challenges, including varying weather conditions and sandy, unstable court surfaces. Despite its popularity, there is a notable lack of scientific research addressing the metabolic and immune responses of elite female athletes in this sport. This study aims to address this gap by investigating two world-class Olympic medalists, female BVb players, who represent a country with a rich history in the sport. Methods: Two athletes underwent a simulated competition day consisting of two matches. A standardized protocol was utilized to collect blood and urine samples at seven time points, allowing for analysis throughout the competition and recovery phases. The analysis included various electrolytes, as well as hematological, metabolic, and inflammatory markers. Additionally, we assessed selected hormones, such as insulin, serotonin, ACTH, and cortisol, along with amino acids related to energy metabolism and neurotransmitter synthesis. Results: Both athletes presented a trend toward electrolyte disturbances, especially hypokalemia, with a mean decrease of 15% and individual values reaching as low as 3.3 mmol/L post-match. This indicates that BVb may pose a risk for such disturbances. Additionally, the matches led to 20% to 60% increases in muscle injury markers, with incomplete recovery even after a day of rest, signaling persistent physiological stress post-competition. This increase was matched by stimulating stress hormones (ACTH and cortisol rose up to 4-fold and 3-fold, respectively), and markers of exercise intensity, such as lactate and ammonium. Moreover, the simulated BVb competition day impacted the amino acid response, with the Fischer ratio (BCAA/AAA) and blood tryptophan decreasing to a minimum of 60% of the initial levels and blood serotonin increasing by up to 180%, which are signs of an increased risk of central fatigue onset, according to the Fischer and Newsholme theory. Conclusions: The responses examined in this exploratory study contribute to a deeper understanding of the metabolic and immune demands placed on elite female BVb players, suggesting practical applications. By addressing the similar physiological responses observed among the athletes and emphasizing their unique individual responses—despite following the same protocol under identical conditions and sharing similar life habits for an extended period—this study highlights the critical necessity for the n-of-1 monitoring of athletes
insights from the international multicenter ISACS-STEMI registry
No full textPublisher Copyright: © 2022. The Author(s).BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. METHODS: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. CONCLUSION: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL REGISTRATION NUMBER: NCT04412655 (2nd June 2020).publishersversionpublishe
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The Second International Asteroid Warning Network Timing Campaign: 2005 LW3
No full textThe Earth close approach of near-Earth asteroid 2005 LW3 on 2022 November 23 represented a good opportunity for a second observing campaign to test the timing accuracy of astrometric observation. With 82 participating stations, the International Asteroid Warning Network collected 1046 observations of 2005 LW3 around the time of the close approach. Compared to the previous timing campaign targeting 2019 XS, some individual observers were able to significantly improve the accuracy of their reported observation times. In particular, U.S. surveys achieved good timing performance. However, no broad, systematic improvement was achieved compared to the previous campaign, with an overall negative bias persisting among the different observers. The calibration of observing times and the mitigation of timing errors should be important future considerations for observers and orbit computers, respectively. © 2023. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
