1,721,064 research outputs found
Female and male human babies have distinct blood metabolomic patterns
No full textA sex-gender approach in laboratory medicine is scarce; furthermore, the influence of sex on acylcarnitines
and amino acid levels at birth has not been thoroughly investigated, even if sex impacts on newborn
screening. We aimed to establish the influence of sex on amino acids and acylcarnitines levels in male and
female newborns. Amino acids and acylcarnitines were analysed in dried blood spots using tandem mass
spectrometry in male and female newborns. Data were analysed before and after body weight correction also
using principal components analysis. This retrospective analytical study showed that females had small but
significantly higher levels of amino acids and the correction for body weight amplified these differences.
Acylcarnitines were overall higher in males before body weight correction with the exception of
isovalerylcarnitine + methylbutyrylcarnitine (C5), which was significantly higher in females. Body weight
correction decreased the sex differences in C5. Principal component analysis showed that both amino acids
and acylcarnitines were necessary to describe the model for females, whereas only acylcarnitines were
required for males. These metabolomics data underline the importance of including sex as a variable in future
investigations of circulating metabolites; the existence of sex differences highlights the need for setting distinct
reference values for female and male neonates in metabolite concentration
Reoxygenation dysrhytmias in the isolated guinea-pig heart: sensitivity to prazosin, atenolol and practolol
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Differential inhibitory effect of Taurine on contractile responses to potassium and noradrenaline in rabbit ear artery
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Post-natal repeated mild stress induce changes in brain NAD(P)H reducycling in adult male mice: role of the opioid system
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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