1,720,955 research outputs found
EP12.15 THE CORRELATION OF OBESITY AND INCIDENCE OF GLIOBLASTOMA WHO GRADE 4
No full textAbstract BACKGROUND Glioblastoma (GBM) is the most common and aggressive primary brain neoplasia in adults. In recent years, a correlation of obesity and an incidence of tumors was shown for many solid cancers, including brain tumors. The present study aimed at determining the effects of lifestyle and dietary habits in the development of Glioblastoma WHO 4 and their effect in the overallsurvival after the operation. MATERIAL AND METHODS A retrospective review was performed for all patients with a histologically proven and first-diagnosed GBM between 2019 and 2023 in our department. Clinical and paraclinical parameters were acquired from patient documentation. Our study includes patients first diagnosed with primary GBM WHO Grade 4, IDH wildtype. Individuals with a secondary GBM or missing preoperative data were excluded. Data analysis of each patient included gender, age, BMI, Karnofsky performance score, tumor location and postoperative survival time. RESULTS In this study, 101 patients with a first diagnosed primary GBM were included (54 males, 47 females; mean age of 62.7 years, and range 33 to 82 years). All patients got a gross total resection. All of them received the standard adjuvant treatment according to Stupp et al. 52 Patients were overweight- Class I obesity, 18 patients had class II. Only 2 Patients were underweight and 29 patients had a normal weight. Ca. 69,3% of the patients with GBM were obese. Our study shows that there is an association between glioblastoma and overweight. Normal weight patients had a mean overall survival of 386.7, the obese patients had a mean OS of 463 days. 22 of the obese patients (from 70, ca. 31.4%) had an OS over mean OS (>463 days). This shows that the obesity does not impact the overallsurvival. CONCLUSION Our study finds an association of patient’s BMI with GBM’s incidence, but doesn’t show a relationship between BMI and OS
EP17.04 SURGICAL REMOVAL OF THORACIC EPIDURAL EWING SARCOMA WITH DOUBLE DOOR LAMINOPLASTY
No full textAbstract BACKGROUND Intraspinal Ewing’s sarcoma lesions are rare occurrences. Limited clinical research exists regarding the surgical treatment options and prognosis of these tumors. We report a case of thoracic extradural Ewing’s sarcoma in a 14-year-old-girl, where we performed the double door laminoplasty technique for the removal of the tumor. MATERIAL AND METHODS The 14-year-old patient had a progressive neck and shoulder pain of a duration of one month. Her body examination showed a rapidly progressive severe paraparesis and hypoesthesia from Th6 in both legs. Her MRI revealed a sizable paravertebral mass located at the Th3 level on the right side, displaying extension along the rib and into the spinal canal through the neuroforamen. The portion from Th2 to Th4 (intraspinal extradural) exhibited a conspicuous space-occupying effect, leading to substantial compression of the spinal cord and signaling myelopathy. Due to the clinical and imaging findings, we opted for an immediate spinal decompression and tumor resection. To maintain the stability after operation, we performed a double door laminoplasty from Th2 to Th4. The block comprising the three laminae was gradually separated from the underlying tumor and extracted en bloc. Residual tumor fragments from the extracted laminae were carefully removed with the intention of reinsertion. Since the three removed laminae did not exhibit osseous infiltration or destruction, we reinserted them. The diagnosis was confirmed histologically. The patient had a significant reduction of the pain and improvement in her neurological deficits. The adjuvant therapy was started 3 weeks after the operation. RESULTS The open door laminoplasty technique has been previously used to treat cervical spondylotic myelopathy. We adapted it successfully for this thoracic case. Neither spinal malalignment nor displacement of bone flap (laminoplasty flap) were observed on postoperative examinations. No complications were encountered. CONCLUSION Ewing’s sarcoma typically affects children and young adults. However, the exact prevalence of extradural thoracic Ewing sarcoma remains unknown due to its rarity. It is impossible to definitively conclude which surgical modality is the best for these cases, but our case shows that a tumor resection with double door laminoplasty can be an optimal mode of treatment
EP14.03 RAPID RECURRENCE OF A ASTROBLASTOMA IN A YOUNG ADULT.
No full textAbstract BACKGROUND Astroblastoma is a rare neuroepithelial brain tumor of uncertain origin, primarily affecting children and young adults. It accounts for 0.45-2.8% of all neuroglial tumors. Diagnosing astroblastoma is challenging due to its resemblance to other glial neoplasms in both histopathology and imaging. These tumors are typically large, peripheral, and located in the frontoparietal hemispheres, though they can also appear in the cerebellum, brainstem, or hypothalamus. Symptoms include headache, vomiting, nausea, seizures, and altered consciousness. MATERIAL AND METHODS The 33-year-old patient had a progressive dizziness of two weeks. She had no history of trauma, serious medical problems or family history of brain tumors. Physical examinations showed normal vital signs and no focal neurologic deficits. Her brain- MRI revealed a large contrast medium uptake/ lesion parietooccipital at the left side. Due to the clinical and imaging findings, we opted for the tumorresection. The histology showed an astroblastoma. The patient had no neurological deficits. She got a postoperative radiochemotherapy according to Stupp, 8 weeks after the operation. The MRI-Control showed a progress of the resttumor. We followed up at 3 and 6 months. The last MRI showed a stable disease. RESULTS Astroblastoma is an extremely rare tumor that was previously referred to as “neuroepithelial tumors of uncertain origin”. Currently, the WHO classification of CNS tumors categorizes astroblastomas as “other neuroepithelial tumors”. A bimodal age distribution is commonly observed, with most reported cases presenting between the ages of 10 and 30. CONCLUSION Due to the rarity of astroblastoma and the difficulties in diagnosing it at an early stage, there is no established standard treatment. High-grade astroblastomas typically have a poor prognosis, characterized by invasion of surrounding brain regions, high recurrence rates, and rapid progression. In such cases, aggressive treatment and ongoing monitoring are crucial
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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