807 research outputs found
Cutting'aesthetic teeth' : Flannery O'Connor's habit of art
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e ExpressãoEste trabalho foi sugerido pela afirmação de Flannery O'Connor que sua "dedicação estética" nasceu através do contato com Art and Scholasticism de Jacques Maritain. O propósito foi chegar a uma interpretação do sentido da frase. Uma investigação detalhada foi feita do conteúdo de Art and Scholasticism, posteriormente contrastada com os resultados de uma pesquisa feita em seus ensaios e suas cartas, o que revelou numerosos ecos de diversos trechos constando no texto de Maritain. Três pontos principais foram escolhidos como critérios na análise do hábito artístico de O'Connor: 1) a prática de arte implica uma luta; 2) a arte somente pode ser percebida pelos sentidos; e 3) a prática de arte exige do artista a dedicação indivisa à obra nascente. O estudo conclui que, para O'Connor, o brotar da dentição estética, através da leitura de Art and Scholasticism, significou que, ao perceber na análise da natureza da arte algo com que podia concordar, ela reconheceu tanto sua própria capacidade de tornar-se uma artista literária, quanto sua vontade de assumir a tarefa de desenvolver em sua pessoa o hábito de arte
SRP128025
No full textSRP128025 at the NCBI Sequence Read Archive contains raw MiSeq reads for each individual sample. Note that not all samples were analyzed in: Assembly and ecological function of the root microbiome across angiosperm plant species, Fitzpatrick, Connor, Copeland, Julia, Wang, Pauline W., Guttman, David S., Kotanen, Peter M., Johnson, Marc T. J
Consolations of the law: jurisprudence and the constitution of deliberative politics
No full textInitially, deliberative politics offers a failure of self-identity in that the literature dealing with it divides between its determinate elevation in terms of reason, and such, and its dissipation in response to the diversity of interests pressing on it. Next, drawing on the resources of poststructural jurisprudence and by way of locating law at a defining limit of deliberative politics, a similar divide is found in law itself. Then, more productively, law is shown to be constituted with-in that divide and to take characteristic content from it. Finally, the analysis is returned to deliberative politics where the divide found in the literature can now be seen as offering this politics possibilities of effective constitution and distinctive content
Factor structure and psychometric properties of the Connor-Davidson Resilience Scale among Chinese adolescents
No full textObjectives: Resilience refers to psychological characteristics that promote effective coping and positive adaptation in adversity. This study investigated the factor structure and psychometric properties of the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC) among adolescents
Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome
No full textCo-author Caroline Connor is a student in the Neuroscience and MD/PhD programs in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School. Aslihan Dincer is a student in GSBS' Bioinformatics and Computational Biology program.Maternal immune activation during prenatal development, including treatment with the viral RNA mimic, polyriboinosinic–polyribocytidilic acid (poly IC), serves as a widely used animal model to induce behavioral deficits reminiscent of schizophrenia and related disease. Here, we report that massive cytokine activation after a single dose of poly IC in the prenatal period is associated with lasting working memory deficits in adult offspring. To explore whether dysregulated gene expression in cerebral cortex, contributes to cognitive dysfunction, we profiled the cortical transcriptome, and in addition, mapped the genome-wide distribution of trimethylated histone H3-lysine 4 (H3K4me3), an epigenetic mark sharply regulated at the 5′ end of transcriptional units. However, deep sequencing-based H3K4me3 mapping and mRNA profiling by microarray did not reveal significant alterations in mature cerebral cortex after poly IC exposure at embryonic days E17.5 or E12.5. At a small set of genes (including suppressor of cytokine signaling Socs3), H3K4me3 was sensitive to activation of cytokine signaling in primary cultures from fetal forebrain but adult cortex of saline- and poly IC-exposed mice did not show significant differences. A limited set of transcription start sites (TSS), including Disrupted-in-Schizophrenia 1 (Disc1), a schizophrenia risk gene often implicated in gene–environment interaction models, showed altered H3K4me3 after prenatal poly IC but none of these differences survived after correcting for multiple comparisons. We conclude that prenatal poly IC is associated with cognitive deficits later in life, but without robust alterations in epigenetic regulation of gene expression in the cerebral cortex
A one-dimensional tearing mode equation for pedestal stability studies in tokamaks
No full textStarting from expressions in Connor et al. (Phys. Fluids, vol. 31, 1988, p. 577), we derive a one-dimensional tearing equation similar to the approximate equation obtained by Hegna & Callen (Phys. Plasmas, vol. 1, 1994, p. 2308) and Nishimura et al. (Phys. Plasmas, vol. 5, 1998, p. 4292), but for more realistic toroidal equilibria. The intention is to use this approximation to explore the role of steep profiles, bootstrap currents and strong shaping in the vicinity of a separatrix, on the stability of tearing modes which are resonant in the H-mode pedestal region of finite aspect ratio, shaped cross-section tokamaks, e.g. the Joint European Torus (JET). We discuss how this one-dimensional model for tearing modes, which assumes a single poloidal harmonic for the perturbed poloidal flux, compares with a model that includes poloidal coupling Fitzpatrick et al. (Nucl. Fusion, vol. 33, 1993, p. 1533).</jats:p
Unique bacterial composition and assembly in a parasitic plant
No full textHow plant-associated microbiota are shaped by, and potentially contribute to the unique ecology and heterotrophic life history of parasitic plants is relatively unknown. Here, we investigate the leaf and root bacterial communities associated with the root holoparasite Orobanche hederae and its host plant Hedera spp. We sequenced the V4 region of the 16S rRNA gene from DNA extracted from leaf and root samples of naturally growing populations of Orobanche and infected and uninfected Hedera. Root bacteria inhabiting Orobanche were less diverse, had fewer co-associations, and displayed increased compositional similarity to leaf bacteria relative to Hedera. Overall, Orobanche bacteria exhibited significant congruency with Hedera root bacteria across sites, but not the surrounding soil. Infection had localized and systemic effects on Hedera bacteria, which included effects on the abundance of individual taxa and root network properties. Collectively, our results indicate that the parasitic plant microbiome is derived but distinct from host plant microbiota, exhibits increased homogenization between shoot and root tissues, and displays far fewer co-associations among individual bacterial members. Host plant infection is accompanied by modest changes of associated microbiota at both local and systemic scales compared with uninfected individuals. The results are a first step towards extending the growing insight into the assembly and function of the plant microbiome to include the ecologically unique but often overlooked guild of heterotrophic plantsPPM_Analysis_Code_Dryad.R: R script used to process Illumina sequencing reads and perform all data formatting, statistical analyses, and figure generation.
PPM_bac.tre: Phylogenetic tree of all bacterial ASVs generated from the R package 'DADA2'. We used the software PASTA to generate the bacterial tree.
RDP_taxa.rds: R object that contains the taxonomy associated with each bacterial ASV generated from the R package 'DADA2'. We used the RDP classifer as implemented in DADA2 to assign taxonomy using the RDP training set 16.
sample_yields.csv: DNA concentration of the original DNA extractions and final amplicon libraries.
spe_table.rds: an ASV table which ennumerates the number of reads associated with each ASV in each sample. This data table was generated from the R package 'DADA2' and was used for all downstream analyses.
Funding provided by: NSFCrossref Funder Registry ID: http://dx.doi.org/10.13039/100000001Award Number: DEB-160150
PRICE-FIXING OVERCHARGES: LEGAL AND ECONOMIC EVIDENCE
No full textThis paper surveys hundreds of published social-science studies of private, hard-core cartels that contain 699 observations of long-run overcharges. The primary finding is that the median cartel overcharge for all types of cartels over all time periods is 25%: 19% for domestic cartels, 32% for international cartels, and 31% for all successful cartels. Thus, international cartels have historically been about 68% more effective in raising prices than domestic cartels. Cartel overcharges are skewed to the high side, pushing the mean overcharge for all types of cartels over all time periods to 42%. "Peak" cartel overcharges are typically double those of the long-run averages. These results are generally consistent with the few, more limited, previously published works that survey cartel overcharges. There is no evidence that convicted cartels are markedly less effective than unpunished ones. The results of a second survey of final verdicts in decided U.S. horizontal collusion cases, only three of which were international cartels, show an average median overcharge of 21% and an average mean overcharge of 30%. Outside the United States, 62 decisions of competition commissions cited median average overcharges of 25% and a mean of 47%. There are three significant policy implications. First, there is a view among some antitrust writers that there is little evidence that cartels raise prices significantly for a period long enough to justify the height of current U.S. cartel penalties. This survey's results, which are based upon an extraordinarily large amount of data spanning a broad swath of history of all types of private cartels, sharply contradict these views. In fact, the data suggest that U.S. penalties ought to be increased. Mean overcharges are three times as high as the level presumed by the U.S. Sentencing Commission. Surprisingly, bid rigging was no more injurious than other forms of collusion, which suggests that the USSC should amend its Guidelines that currently treat bid rigging more harshly than other forms of collusion. Second, the principal antitrust authorities abroad often base their typical or maximum fines on a 10% harm presumption. Average fines imposed since 1995 by Canada and the EU on identical cartels have been lower than U.S. government fines, yet overcharges generated by cartels discovered outside the United States are higher than North America-centered cartels. Consequently, anticartel laws and fine-setting practices abroad are in even greater need of strengthening. Third, cartels with multi-continental price effects are the most harmful type. Despite the evident increases in cartel detection rates and the size of monetary fines and penalties in the past decade, a good case can be made that current global anticartel regimes are under-deterring. While the recent worldwide trend towards the intensification of cartel penalties has been desirable, global cartels are more difficult to detect, have less fear from entry of rivals, achieve higher levels of sales and profitability, and systematically receive weaker corporate sanctions than comparable domestic cartels. Antitrust sanctions worldwide should be higher for global cartels than for other types.International Relations/Trade,
Correction to: Understanding the key processes of excellence as a prerequisite to establishing academic centres of excellence in Africa
No full textCorrection to: BMC Med Educ 21, 36 (2021) https://doi.org/10.1186/s12909-020-02471-0 Following publication of the original article [1], the authors identified an error in the author name of Conor R. Caffrey and also in his affiliation. The incorrect author name is: Connor Caffery The correct author name is: Conor R. Caffrey The incorrect author affiliation is: Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, USA. The correct author affiliation is: Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA The original article has been corrected
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