1,721,113 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Regulatory safety aspects of advanced therapy medicinal products (ATMPs)
No full textAdvanced therapy medicinal products (ATMPs) such as gene-, cell- and tissue engineered therapies offer tremendous potential for treating unmet medical needs. Due to the novelty, complexity and technical specificity of such products, specially tailored and harmonized rules are needed to evaluate their safety and efficacy. Despite rapid progress in research and the wide range of ATMPs undergoing pre-clinical and clinical development, the number of licenced products still remains low. In order to determine the main factors, which complicate the translation from ATMPs research into patient access, the feedback from main stakeholders i.e. representatives of product manufacturers, regulatory authorities and patients' associations was collected in semi-structured interviews. The main focus was on pre-clinical safety testing and the relevant regulatory considerations. Numerous factors have been identified as limitations preventing more rapid market authorization for ATMPs. The key challenges in pre-clinical development considered availability of the right animal model for the specific disease, current approaches in immunogenicity testing and insertional site analysis as well as determining appropriate dosing strategy. Concerns regarding the lack of validated (bio)analytical methods and insufficient programs for environmental risk monitoring were raised. A specific identified challenge for the ATMPs sector was the difficulty to meet all the requirements to obtain market authorization from regulatory authorities, especially for products developed for European and non-European markets simultaneously, and a great heterogeneity in the legal requirements at the national level for products developed for non-routine use. To address these knowledge gaps and regulatory challenges, numerous international collaboration projects and initiatives have been already undertaken. It is likely that the introduction of ATMPs will follow an incremental pattern of technological and regulatory change, building on existing drug development and regulation heuristics and experiences. A necessary open dialog and continuous collaboration between stakeholders is considered as key to learn and grow together in this new field and to design solid guidelines for the safe implementation of advanced therapies as medicinal treatment
In vivo safety testing of antibody drug conjugates
No full textAntibody Drug Conjugates (ADCs) are complex multi-domain biotherapeutics which combine, with the aid of a chemical linker, the tumor targeting properties of antibodies to the potent cytotoxicity of a selected small molecule (also called warhead or payload) to obtain novel pharmaceuticals for the treatment of cancer. ADCs are a rapidly growing class of pharmaceuticals with seven FDA-approved drugs already on the market and over eighty investigated at different stages of clinical development (1). The careful design of each of the ADC's building blocks allows to maximize anti-tumor efficacy while reducing the toxicity to healthy tissues. The preclinical characterization of these novel therapeutics requires the careful balance of the known requisites for small and biotechnology-derived molecules with a keen eye to the need of new effective treatments in the fight against cancer. From the analysis of official approval documents, available literature and current guidelines, this thesis will present the common features and peculiarities of the in vivo safety assessment of this emerging group of drugs. Moreover, this document will highlight the need for integrated and novel strategies for the preclinical evaluation of ADCs, stemming from their complex multi domain structure which sets them apart from both standard chemotherapy and antibody-based products
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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