18 research outputs found
The Relationship between Sleep Quality and the Incidence of Gastroesophageal Reflux Disease (GERD): A Study on Clinical Clerkship Students, Faculty of Medicine, Universitas Prima Indonesia
No full textGastroesophageal reflux disease (GERD) is defined as a gastrointestinal motility disorder caused by the reflux of gastric contents into the esophagus or oral cavity. This results in symptoms or complications if persistent, resulting in a significant reduction in quality of life and morbidity. Several studies have reported an association between nocturnal GERD and sleep disturbances, which can significantly affect the quality of life. This study explores the relationship between sleep quality and the incidence of GERD in clinical clerkship students at the Faculty of Medicine, Universitas Prima Indonesia. This study is a cross-sectional observational study involving 144 clinical clerkship students. The GERDQ was used to diagnose GERD, and the PSQI questionnaire was used to measure sleep quality. Respondents who did not suffer from GERD with good sleep quality were 32 respondents (22.2%). Those who did not suffer from GERD with poor sleep quality were 65 respondents (74.8%), who suffered from GERD with good sleep quality only 1 respondent (10, 8), and 46 respondents (36.2%). There is a significant relationship between sleep quality and GERD in clinical clerkship students at the Faculty of Medicine, Universitas Prima Indonesia
KARAKTERISTIK PENDERITA TUMOR SISTEM REPRODUKSI WANITA DENGAN PEMERIKSAAN HISTOPATOLOGI DI RUMAH SAKIT UMUM MADANI MEDAN PERIODE TAHUN 2018 – 2022
No full textTumor sistem reproduksi wanita merupakan jenis sel tumor yang dapat tumbuh di berbagai organ sistem reproduksi wanita. Berdasarkan data Rikesdas, pravelensi tumor di Indonesia tahun 2018 terdapat 1.017.290 (1,79%) dari 278,8 juta penduduk. Tujuan penelitian untuk mengetahui karakteristik penderita tumor sistem reproduksi wanita dengan pemeriksaan histopatologi di Rumah Sakit Umum Madani Medan Periode Tahun 2018–2022. Jenis penelitian menggunakan pendekatan deskriptif retrospektif, sumber data yang diambil data sekunder yaitu rekam medik dengan metode total sampling sebanyak 234 orang. Analisis hasil penelitian dilakukan dengan analisis statistik frekuensi menggunakan SPSS. Berdasarkan kelompok usia terbanyak yang mengalami tumor sistem reproduksi wanita adalah usia 36-45 tahun sebanyak 103 orang (44,0%), berdasarkan diagnosa histopatologi terbanyak adalah Leiomyoma Uteri sebanyak 129 orang (55,1%), berdasarkan jenis tumor terbanyak adalah tumor jinak sebanyak 234 orang (100%), berdasarkan lokasi tumor terbanyak adalah tumor uterus sebanyak 131 orang (56,0%). Penderita Endometriosis mayoritas berada pada kelompok usia 26–35 tahun sebanyak 16 orang (14,6%), penderita Leiomyoma Uteri mayoritas berusia 36-45 tahun sebanyak 64 orang (62,1%), penderita Mucinous Cystadenoma Ovarii mayoritas berusia 36–45 tahun sebanyak 13 orang (12,6%), penderita Serous Cystadenoma Ovarii mayoritas berusia 36–45 tahun sebanyak 8 orang (7,8%), dan penderita Mature Teratoma mayoritas berusia 26–35 tahun sebanyak 9 orang (2,9%). Mayoritas penderita yang mengalami tumor jinak berada pada kelompok usia 36–45 tahun sebanyak 103 orang (100%). Mayoritas penderita yang mengalami tumor jinak adalah tumor Leiomyoma Uteri sebanyak 129 orang (100%)
Histopathological characteristics of breast tumors at Madani General Hospital Medan
No full textCytology and histopathology include examinations to diagnose breast tumors. The diagnosis of advanced stages of breast tumors can lead to reduced therapeutic options and success. This study aimed to describe the results of cytological and histopathological examinations of patients with breast tumors at the Anatomical Pathology Laboratory of Madani Medan General Hospital between the period 2018-2022. This study was descriptive and retrospective. The study population included all the medical records of patients diagnosed with breast tumors. The research sample consisted of the medical records of patients with FAM and Carcinoma Mammae obtained by consecutive sampling. The results of cytological and histopathological examinations showed that the majority of breast tumor patients were both aged 17-25 years with a percentage of 42.9% and 52.4%, respectively). The results of the cytological examination showed that the majority of patients had benign tumor diagnoses (85.7%) and histology (90.5%). Malignant tumors were diagnosed based on the results of cytological examination (14.3%) and histology (9.5%). Based on the relationship between age. Based on the relationship between age and diagnosis of benign and malignant tumors, the results of cytological examination showed that patients aged 12-16 years, 17-25 years, and 26-35 years all had benign tumors (100%), patients aged 36-45 years had benign tumors (50.0%) and malignant tumors (50.0%), and patients aged 56-65 years all had malignant tumors (100.0%). Histopathological examination results showed that patients aged 12-16 years, 17-25 years, 26-35 years, and 36-45 years all had benign tumors (100%), patients aged 46-55 years had benign tumors (50.0%) and malignant tumors (50.0%), and patients aged 56-65 years all had malignant tumors (100.0%)
Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus)
No full textSkin, as the largest organ in the human and animal body, serves as the main protection against various external factors such as sharp objects, extreme temperatures, chemicals, or physical trauma. This study aims to evaluate the effectiveness of seaweed (Ulva lactuca) extract-based hydrogel in accelerating incision wound healing in Rattus norvegicus rats. This experimental study used a post-test only controlled group design with six treatment groups: Ulva lactuca hydrogel 5%, 10%, 15%, positive control (Bioplasenton), negative control (wound without treatment), and rat group without treatment. Data were analyzed using ANOVA test. The results showed that Ulva lactuca hydrogel 5% gave the best results in accelerating wound healing. The wound diameter in the 5% group decreased significantly, from 15.3 cm on day 0 to 10.9 cm on day 3, 4.7 cm on day 6, and 2.36 cm on day 14. Histopathology results showed increased epithelialization, decreased inflammation, and increased collagen deposition in the 5% group compared with the control group. Quantitatively, the 5% hydrogel group achieved wound healing up to 30% faster than the positive control and 50% faster than the negative control. The 5% Ulva lactuca hydrogel proved to be most effective in accelerating wound healing by modulating inflammation and promoting tissue regeneration. This concentration provides an optimal balance between efficacy and safety, making it a potential alternative for wound therapy
Profile of Liver Cirrhosis Patients at Imelda Pekerja Indonesia General Hospital (RSU IPI) Period January 2020 – December 2021
No full textLiver cirrhosis is the result or complication of a chronic liver condition where the liver parenchyma is damaged so that its function decreases. This study aims to study the profile of patients with liver cirrhosis at the Imelda Pekerja Indonesia General Hospital in Medan for the period January 2020 - December 2021. This study is a descriptive observational study. A total of 40 samples of medical records of patients with a diagnosis of liver cirrhosis at the Imelda Pekerja Indonesia General Hospital in (IPI) Medan were included in this study. Univariate analysis in the form of frequency distribution data tabulation was used to present the data. The results showed that most patients with liver cirrhosis were male (72.5%), aged 56-65 years (32.5%), and the main complaint was nausea and vomiting (47.5%). The most physical examination results were ascites (52.5%), abnormal lab results were increased SGPT (75%), SGOT (80%), total bilirubin (85%), prothrombin time (75%) and decreased albumin (85%) and Hb (55%), most of the patients were in the category of Child-Pugh Score B (37.5%) and C (37.5%), and the most complication was hepatorenal syndrome (55%). In conclusion, the profiles of patients with liver cirrhosis are mostly male, aged 56-65 years, with the most complaints of nausea and vomiting and the most physical examination findings of ascites. There was an increase in SGPT, SGOT, total bilirubin, and prothrombin time, as well as a decrease in albumin and Hb
Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria
No full textThis research aims to determine the effect of the acute toxicity test of white turmeric extract (Curcuma zedoaria) on the brain organ. This research is experimental research with a Post Test Only Control Group Design. This research was conducted at the Pharmacy and Histology Laboratory. Faculty of Medicine. University of North Sumatra. The research was carried out from January to March 2023. The population in this research involved male white rats (Rattus norvegicus). The results of the acute toxicity test of white turmeric extract for 14 days showed no signs of toxicity or death in rats given the smallest to largest doses, resulting in an apparent LD50 value of white turmeric extract is >2 g/kgBW, and is classified in the practically non-toxic category. Rats that received white turmeric extract showed movement or activity, appearing more energetic by the end of the second week with increasing doses. Histopathological examination of the brain in the acute toxicity test revealed minimal changes, such as edema and congestion in line with increasing doses.This research aims to determine the effect of the acute toxicity test of white turmeric extract (Curcuma zedoaria) on the brain organ. This research is experimental research with a Post Test Only Control Group Design. This research was conducted at the Pharmacy and Histology Laboratory, Faculty of Medicine, University of North Sumatra. The research was carried out from January to March 2023. The population in this research involved male white rats (Rattus norvegicus). The results of the acute toxicity test of white turmeric extract for 14 days showed no signs of toxicity or death in rats given the smallest to largest doses, resulting in an apparent LD50 value of white turmeric extract is >2 g/kgBW, and is classified in the practically non-toxic category. Rats that received white turmeric extract showed movement or activity, appearing more energetic by the end of the second week with increasing doses. Histopathological examination of the brain in the acute toxicity test revealed minimal changes, such as edema and congestion in line with increasing doses
TOXICITY TEST OF WHITE TURMERIC (CURCUMA ZEDOARIA) ON LIVER ORGANS IN WHITE MALE RATS
No full textAbstractWhite turmeric is often used by the people of Indonesia as an herbal plant that has many benefits for the body, one of which is for the liver. But there are still many people who do not know the right and correct dosage in using this white turmeric. The purpose of this study was to determine the toxic dose of white turmeric extract to estimate the degree of damage caused by the extract to the liver. This research design uses experimental research methods by means of Post Test Only Control Group Design. The sample used in this study consisted of 5 rats in each group with a number of groups of rats consisting of 6 groups with a total sample of 30 male white rats of the Wistar strain and in each group different treatments were carried out. Sampling was done using the Simple Random Sampling technique. Rats were divided into 2 control groups, namely equates negative control and NaCMC positive control, and also 4 treatment groups with a dose of 250 mg/kg BW, 500 mg/kg BW, 750 mg/kg BW, and 2000 mg/kg BW. From the results, it was found that the histopathological picture of the control group did not show significant changes, but in the treatment group, the doses of 250 mg/kg BW and 500 mg/kg BW were very clear where there was a lot of severe damage and hydrophilic degeneration began to occur where cell swelling, vacuoles were also found. fat. However, this happens because the liver sample already has a history of disease so that it gives a picture of degeneration. Keywords: acute toxicity test, extract of white turmeric (Curcuma zedoaria), liver histopathology, male white rat Wistar strain Abstrak Kunyit putih sering sekali digunakan oleh masyarakat Indonesia sebagai tanaman herbal yang memiliki banyak manfaat bagi tubuh, salah satunya bagi organ hati. Tetapi masih banyak masyarakat yang belum mengetahui dosis yang tepat dan benar dalam menggunakan kunyit putih ini. Tujuan dilakukannya penelitian untuk mengetahui dosis toksik dari ektrak kunyit putih untuk memperkirakan derajat kerusakan yang diakibatkan oleh ektrak tersebut terhadap organ hati. Rancangan penelitian ini menggunakan metode penelitian eksperimental dengan cara Post Test Only Control Group Design. Sampel yang digunakan dalam penelitian ini terdiri dari 5 ekor tikus setiap kelompok dengan jumlah kelompok tikus terdiri dari 6 kelompok dengan jumlah total sampel 30 tikus putih jantan jenis galur wistar dan di setiap kelompok dilakukan perlakuan yang berbeda- beda. Pengumpulan sampel dilakukan menggunakan teknik Simple Random Sampling. Tikus dibagi menjadi 2 kelompok kontrol yaitu kontrol negatif aquades dan kontrol positif NaCMC, dan juga 4 kelompok perlakuan dengan dosis 250 mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000 mg/KgBB. Dari hasil di dapatkan bahwa gambaran histopatologi kelompok kontrol tidak menunjukkan perubahan yang signifikan, tetapi pada kelompok perlakuan dosis 250 mg/KgBB dan 500 mg/KgBB terlihat sangat jelas dimana banyak kerusakan yang berat dan mulai terjadi degenarasi hidrofilik dimana pembengkakan sel, adanya di jumpai juga vakuola lemak. Namun hal ini terjadi kemungkinan sampel hati sudah memiliki riwayat penyakit sehingga memberikan gambaran degenerasi. Tetapi pada dosis 750 mg/KgBB dan 2000 mg/KgBB dijumpai sel yang mulai membaik dengan menunjukkan adanya perbaikan dimana berkurangnya degenerasi parenkimatosa dan degenerasi hidrofik tetapi masih dijumpai kelainan hati yang abnormal yaitu masih adanya pembengkakan pada sel-sel. Dengan kesimpulan semakin tinggi diberikan dosis dalam perlakuan maka memberikan efek yang positif atau baik terhadap perbaikan kerusakan hati. Keywords: uji toksisitas akut, ekstrak kunyit putih (Curcuma zedoaria), histopatologi hati, tikus putih jantan galur wistar
Perbandingan Gaya Hidup Mahasiswa Urban dan Rural Terhadap Hasil Pembelajaran pada Mahasiswa Fakultas Kedokteran Universitas Prima Indonesia
No full textA student's lifestyle can be influenced by their studio housing friends, the surrounding environment, local culture, and their level of curiosity. Friends in the boarding house are often the main influence in determining students' daily habits, such as eating patterns, recreational activities, and study habits. Consequently, this research aims to identify requency of exercise, length of study, and type of study between students who live in urban areas and those who live in rural areas and the academic achievements of students at the Faculty of Medicine, Prima Indonesia University. Cross-sectional checks at the Prima University Faculty of Medicine included 60 students. A cross-sectional examination of 60 students from the Faculty of Medicine, Prima Indonesia University was the focus of this research. The variables measured in the research are independent variables, namely the lifestyle of urban students and the lifestyle of rural students, while the dependent variable is learning outcomes seen from the Grade Point Average (GPA). The results of the Spearman rank correlation test show that the relationship between exercise frequency, study duration, study method and total student lifestyle respectively has a p value of 0.043, 0.050, 0.000, and 0.006 < 0.05, consequently it can be concluded that, in part, each student's exercise frequency, study time, study mode and overall lifestyle have a significant relationship with their academic performance. student at Faculty of Medicine, Prima University Indonesia
ACUTE TOXICITY OF EXTRACT OF WHITE TURMERIC RHIZOME (CURCUMA ZEDOARIA) REVIEW OF LD50 AND BLOOD CELL COMPONENTS
No full textKunyit putih (Curcuma zedoaria) merupakan tanaman obat tradisional memiliki kandungan fitokimia yang dipercaya penggunaannya sebagai anti atherosklerosis, anti-diabetes, anti-oksidatif, anti inflamasi serta anti kanker. Akan tetapi belum ada penelitian mengenai efek samping tanaman obat tersebut. Kebaruan dalam penelitian ini karena meneliti toksisitas akut ekstrak rimpang kunyit putih ditinjau dari LD50 dan komponen sel darah. Penelitian ini bertujuan untuk menguji toksisitas akut ekstrak rimpang kunyit putih pada komponen sel darah. Kajian ini memakai 30 ekor tikus putih (Rattus novergicus) dan dikelompokkan ke dalam 6 kelompok (kelompok NaCMC 1%, kelompok normal, kelompok perlakuan 250mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000mg/KgBB). Parameter komponen sel darah yang diamati setelah 14 hari perlakuan adalah kadar eritrosit, leukosit, trombosit dan hemoglobin. Data yang terkumpul kemudian dianalisa dengan tes one-way ANOVA serta dilanjut memakai uji PostHoc. Dari hasil kajian ini bisa disimpulkan jika Ekstrak rimpang kunyit putih tidak menyebabkan gejala toksisitas dan mortalitas pada tikus Kata kunci : Kunyit putih; uji toksisitas akut; eritrosit; leukosit; trombosit; hemoglobin. AbstractWhite turmeric (Curcuma zedoaria) is a traditional medicinal plant that contains phytochemicals which are believed to be used as a anti-atherosclerosis, anti-diabetic, anti-oxidative, anti-inflammatory and anti-cancer. Currently there are no studies on the side effects of these medicinal plants. The novelty in this study is because it examines the acute toxicity of white turmeric rhizome extract in terms of LD50 and blood cell components. This research aims to test the acute toxicity of white turmeric rhizome extract on blood cell components. This research use 30 white rats (Rattus novergicus) and grouped into 6 groups (normal group, 1% NaCMC group, treatment group 250mg/KgBW, 500 mg/KgBW, 750 mg/KgBW, and 2000mg/KgBW). Parameters of blood cell components observed after 14 days of treatment were the levels of erythrocytes, leukocytes, platelets and hemoglobin. The collected data was then analyzed use the one-way ANOVA test and then tested by the PostHoc test. From the results of this study, it can be concluded that white turmeric (Curcuma zedoaria) rhizome extract did not cause symptoms of toxicity and mortality in rats .Keywords : white turmeric; acute toxicity test; erythrocytes; leukocytes; platelets; hemoglobin
ACUTE TOXICITY TEST OF WHITE TURMERIC (CURCUMA ZEDOARIA) EXTRACT ON HISTOPATHOLOGICAL ANALYSIS OF THE HEART MUSCLE
No full textKunyit putih (Curcuma zedoaria) adalah tanaman herbal yang banyak digunakan sebagai obat herbal di Asia, khasiatnya dipercaya dapat meningkatkan imun tubuh, sebagai anti nyeri dan anti inflamasi. Penggunaan obat herbal secara umum dipercayai oleh masyarakat memiliki efek samping cenderung rendah dibandingkan obat modern, akan tetapi belum ada banyak penelitian mengenai efek samping dari penggunaan kunyit putih. Kebaruan dalam penelitian ini karena meneliti uji akut ekstrak kunyit putih terhadap analisis gambaran histopatologi otot jantung. Penelitian ini bertujuan untuk menguji toksisitas akut dari ekstrak etanol rimpang kunyit putih terhadap gambaran histopatologi otot jantung. Penelitian menggunakan 30 ekor tikus putih (Rattus norvegicus) dengan berat antara 150-200 gr. Sampel dikelompokkan menjadi 2 kelompok kontrol dan 4 kelompok perlakuan. Perlakuan yang dilakukan yaitu pemberian aquades, NaCMC1%, dosis EKP 250 mg/KgBB, EKP 500 mg/KgBB, EKP 750mg/KgBB, dan EKP 2000 mg/KgBB. Parameter yang diamati adalah hiperemi, hemoragi dan degenerasi dari sel otot jantung. Hasil penelitian ini menunjukkan bahwa tidak terdapat tikus yang mati akibat pemberian EKP, akan tetapi terdapat kerusakan ringan pada dosis EKP 250 mg/KgBB, kerusakan sedang pada dosis EKP 500 mg/KgBB, kerusakan sedang-berat pada dosis EKP 750mg/KgBB dan kerusakan berat pada dosis EKP 2000 mg/KgBB. Berdasarkan hasil penelitian ini, maka dapat disimpulkan bahwa kerusakan sel otot jantung meningkat secara signifikan seiring dengan peningkatan dosis ekstrak etanol rimpang kunyit putih dimana kerusakan sel otot jantung terberat pada dosis EKP 2000mg/kgBB.Kata kunci : jantung; kunyit putih; tikus. AbstractWhite turmeric (Curcuma zedoaria) is a herbal plant that is widely used as herbal medicine in Asia because of its properties which are believed to increase the body's immune system, anti-inflammatory, and an analgesic. The use of herbal medicine is generally believed by the public to have lower side effects than modern medicine, but in reality, there has not been much research on the side effects of white turmeric usage. The novelty in this study was due to the acute study of white turmeric extract on the histopathological analysis of heart muscle. Therefore, this study aims to determine the acute toxicity of white turmeric's rhizome ethanol extract on histopathological features of the heart muscle. This experiment used 30 male white Wistar rats (Rattus norvegicus) with a weight between 150-200 grams. Rats were divided into 2 control groups and 4 groups of treatment. Treatment given to the rats are aquadest, NaCMC 1% WTE 250mg/KgBW, WTE 500mg/KgBW, WTE 750mg/KgBW, and WTE 2000mg/KgBW . The parameters observed are hyperemia, hemorrhage, and degeneration of heart muscle cells. The result showed in this study were that there were no mice that died due to EKP administration, but there was mild damage at WTE dose of 250 mg/KgBB, moderate damage at WTE dose of 500 mg/KgBB, moderate-severe damage at WTE dose of 750mg/KgBB and severe damage on WTE dose of 2000 mg/KgBW. Based on the results of this research, it can be concluded that there is significant damage found along with an increasing dose of white turmeric extract given, where the damage on heart muscle cells is most severe at WTE dose of 2000 mg/KgBW
