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Expression and activity of CYP 1A1 in different brain regions of control and beta-naphthoflavone-treated pigs
No full textExpression and activity of CYP 1A1 in different brain regions of control and beta-naphthoflavone-treated pigs
Gervasi, P.G.1, Chirulli, V.1, Zaghini, A.2, Vaccaro, E.3, Fiorio, R.3, Longo, V.3, Marvasi, L.2
1 Ins. Clinical Physiology, Metabolism, Pisa, Italy; 2 Bologna University, Patologia Veterinaria, Bologna, Italy; 3 Ins. Clinical Physiology, Metabolism, PISA, Italy
The expression of the cytochrome P450 1A1 (CYP 1A1) and its related activities along with the Ah Receptor were investigated in liver and brain regions from control pigs and pigs treated with beta-naphthoflavone (30 mg/kg i.p. for 4 days). By RT-PCR analysis, using specific primers, it was demonstrated that mRNA of CYP 1A1 and AhR were expressed, although at different extent, in the liver, cortex, midbrain and cerebellum. However, the beta-naphthoflavone treatment had no apparent effect on expression pattern of this isoform, unlike liver, in any brain region. Then, some enzymatic activities (ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase), known markers for the CYP 1A1/2, were studied in microsomes of liver and microsomes and mitochondria of cortex, midbrain and cerebellum from control and beta-naphthoflavone treated pigs. The enzymatic analysis revealed a presence of these activities about 3-4 times higher in mitochondria than in microsomes from all the brain regions examined. However, in contrast to the behaviour of the liver, beta-naphthoflavone treatment did not induce the cerebral activities. Despite the presence of AhR, the CYP1A1 in the pig brain was resistant to beta-naphthoflavone induction suggesting that there is a different regulation mechanism of this enzyme between the brain and liver
Indagine su frequenza di disturbi emotivi e consumo di psicofarmaci in lavoratori esposti al piombo in una industria di accumulatori.
No full textPsychiatric screening in general practice in Italy. A validity study of the GHQ (General Health Questionnaire).
No full textPsychotropic drug use in Italy: National trends and regional differences
No full textUsed 1975-1984 drug sales data for Italy to examine national trends in psychotropic drug use. Results indicate annual increases in the sales of antidepressants, minor tranquilizers, and, to a lesser extent, neuroleptics. Regional variations in psychotropic drug use were found in an examination of 1983-1984 data. The results emphasize the need to consider the phenomenon of psychotropic drug use in a context that extends beyond the clinical setting to include broader social, economic, and political perspectives. (PsycLIT Database Copyright 1988 American Psychological Assn, all rights reserved
Pazienti psichiatrici lungodegenti ed utenti lungoassistiti a Verona-Sud. Uno studio epidemiologico
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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