2,024 research outputs found
Interview with Jacqueline DeGroot
No full textJacqueline DeGroot, author of Climax and Worth Any Price, discusses how she came to be a writer, her writing process and sources of inspiration, and her experiences with self-publishing
Jacqueline Woodson: 2023 Irma Black Award Silver Medal Acceptance Speech
No full textAuthor Jacqueline Woodson gives an acceptance speech for The World Belonged to Us, illustrated by Leo Espinosa (Penguin)https://educate.bankstreet.edu/irma_black_awards/1011/thumbnail.jp
Leslie Behm interviews essayist and fantasy writer Jacqueline Carey
No full textEssayist and fantasy writer Jacqueline Carey talks about the meaning of the title of her Kushiel Trilogy, how she became an author, her work in progress. She also gives advice to aspiring authors. Carey is interviewed by Michigan State University librarian Leslie Behm. Part of the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
sj-pdf-1-ome-10.1177_00302228211045288 - Supplemental material for Exploring the Use of Virtual Funerals during the COVID-19 Pandemic: A Scoping Review
No full textSupplemental material, sj-pdf-1-ome-10.1177_00302228211045288 for Exploring the Use of Virtual Funerals during the COVID-19 Pandemic: A Scoping Review by Andie MacNeil, Blythe Findlay, Rennie Bimman, Taylor Hocking, Tali Barclay and Jacqueline Ho in OMEGA—Journal of Death and Dying</p
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Jacqueline Barnitz: 40 Years of Publications
No full textJacqueline Barnitz: 40 Years of Publications
Jacqueline Barnitz is responsible for establishing modern Latin American art as an area of concentration
within art history at the University of Texas at Austin, where she has taught now for 25 years. She's a
major reason why UT Austin is known as the best place in the nation for studying modern Latin American
art. A notable record of publication accompanies her career as a distinguished educator. In fact, her
interest in Latin American art goes back to her tenure as an art critic in New York for the periodicals Art
Voices (1964-1965) and Arts Magazine (1964-1975). Additionally, she's been the curator of numerous art
exhibitions and, subsequently, the author of many exhibition catalogs. In 2000 UT Press published her
much-anticipated and seminal book Twentieth-Century Art of Latin America, which quickly became the
textbook on the subject. We present this display of selected publications as a tribute to her outstanding
contributions to the university and to the field of art history.UT Librarie
Klebsiella pneumoniae: a progression to multidrug resistance
No full textKlebsiella pneumoniae is a common cause of nosocomial and community-acquired
infections, and the increasing incidence and prevalence of antibiotic resistant strains
is proving to be particularly problematic to clinicians. K. pneumoniae is capable of
employing a multitude of mechanisms by which to confer resistance to most
available antibiotics. The carbapenem antibiotics are usually reserved for the
treatment of complicated or multidrug resistant (MDR) K. pneumoniae infections.
The recent emergence of not only MDR but also pan-drug resistant (PDR) K.
pneumoniae strains has signified that it is now more important than ever to
understand the mechanisms by which these strains confer resistance so that we may
find ways to combat or hinder this progression. This project aimed to investigate the
regulation of the transcriptional activator RamA, its ability to confer a MDR
phenotype, and the mechanisms employed by K. pneumoniae to confer levels of
carbapenem resistance sufficient to result in therapy failure.
The analysis of a panel of K. pneumoniae strains, containing both RamA expressers
and non-expressers, demonstrated that the overexpression of RamA was sufficient to
confer an MDR phenotype. Two compounds, chlorpromazine (CPZ) and tigecycline,
were shown to act as inducers of ramA, romA and acrA transcription. CPZ exhibited
synergy with the antibiotics chloramphenicol, norfloxacin and tetracycline, all of
which are known substrates of the AcrAB efflux pump. The current lack of novel
classes of antimicrobials in development indicate a potential for a compound, such as
CPZ, to be developed and exploited for clinical use. The ability of both CPZ and tigecycline to cause mutations within ramR however, indicate that both compounds
may have the ability to select for efflux mutants as a result of their ability to
upregulate ramA, which in turn causes the upregulation of the AcrAB efflux pump.
The regulation of RamA by the upstream gene ramR, which encodes a TetR family
protein was investigated in K. pneumoniae isolates. Sequencing of the ramR genes
revealed that strains exhibiting an MDR phenotype commonly contained mutations
within their gene sequences. The complementation of a wildtype ramR into a strain
containing a 32 amino acid deletion within its ramR, was shown to increase
susceptibility to various antibiotics of different classes, and additionally
downregulate the expression of ramA, romA and acrA. CPZ, ciprofloxacin and
tigecycline K. pneumoniae mutants were shown to exhibit increased MICs to a broad
spectrum of antibiotics with respect to their parent strains, and possess mutations
within their ramR genes. Complementation of the wildtype ramR resulted in partial
reversion to the parental phenotypes, indicating another mechanism must also be
involved in conferring the MDR phenotypes. These studies indicated that RamR
plays an important role as a negative regulator of RamA, but also that it is not the
sole regulator.
The development of reduced susceptibility to the carbapenems was investigated in
two clinical strains of K. pneumoniae, K1 and K2, isolated from the urine of a single
patient at different stages of antibiotic therapy. The strains were shown to exhibit
similar resistance phenotypes with the exception of their susceptibilities to the
carbapenems. PCR and phenotypic analyses revealed that neither strain contained any carbapenemases or AmpC enzymes, but both contained OXA-1, SHV-1 TEM-1
and CTX-M-15. Analysis of their OMP profiles indicated that both strains lacked
OmpK35, and K2 additionally lacked OmpK36. Mutation studies showed that the
phenotype and OMP profile exhibited by K2 could be achieved in K1 via single step
mutations using ertapenem, imipenem or meropenem. Susceptibility testing of CTXM-
15 clinical strains showed that strains containing CTX-M-15 showed reduced
activity against ertapenem in the presence of clavulanic acid. These studies indicated
a potential role for CTX-M-15 in conferring reduced susceptibility to the
carbapenems when found in conjunction with altered permeability and active efflux.
The mechanisms of antibiotic resistance employed by K. pneumoniae are numerous
and complex. This work highlights several of these mechanisms and, more
importantly, how they can work in synergy with one another to devastating
consequences
First person – Jacqueline Weidner
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open (BiO), helping early-career researchers promote themselves alongside their papers. Jacqueline Weidner is first author on ‘Hormones as adaptive control systems in juvenile fish’, published in BiO. Jacqueline conducted the research described in this article while a PhD student at the University of Bergen, Norway. She is now an assistant professor at the Western Norway University of Applied Sciences, Norway, investigating sexual selection and modelling of evolutionary patterns
Jacqueline Risset. Scritture dell’istante
No full text“Born on 25th May 1936. Two specific desires: not to become an adult, and to write”. Jacqueline Risset (1936-2014) was a translator from French (Ponge, Sollers, the Tel Quel poets) and Italian (Dante, Machiavelli, Balestrini), as well as a well-known scholar for her work on Scève, Proust and Bataille. The aim of this volume is to analyse Risset’s poetic work, from the beginnings with textual writing in the experimentalism of Tel Quel, through a trajectory that, crossing Dante and Stilnovism through the translation of the Divine Comedy, led the author to the elaboration of a poetics centred on “privileged instants” that open “to the elsewhere”
Dialogue of the Western World 2: Antigone, April 25, 1972
No full textDialogue of the Western World 2: Antigone, April 25, 1972. With an introduction by Greg Otto, the host (Dr. Robert Goldwin) discusses "Antigone" with author Jacqueline Wheldon and three students from St. John's College, Joanne Morris, Christine Constantine, and Michael Jordan
Are We There? Depends on View of the Economy
No full textAuthor\u27s biography: Jacqueline K. Eastman is an associate professor of marketing at Georgia Southern University. She may be reached at [email protected]
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