1,721,158 research outputs found
Tapentadol prolonged release in the treatment of musculoskeletal pain: an innovative pharmacological option
Full text linkMusculoskeletal pain, encompassing back and osteoarthritis (OA) pain, represents the most frequent source of chronic pain in western countries. and it is particularly frequent in older adults. Remarkably. back and OA pain present. in most cases, both a nociceptive and a neuropathic component of pain. Treatment selection should, therefore, properly consider the ability of a drug to act on both components, reducing the possibility of plastic changes in the central nervous system, and consequently promoting physical rehabilitation.The pharmacological profile of tapentadol, combining synergistically mu-opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI) in one single molecule with a concomitant reduction in the burden of adverse events, is unique, to date, and makes this drug particularly suitable for the treatment of back pain and OA-associated pain, especially when a neuropathic component is present.Tapentadol is an innovative dual-acting analgesic molecule, which combines two mechanisms of action, namely MOR agonism and NRI. This narrative review will briefly discuss the pharmacological action of tapentadol and its rationale of use in back pain and OA
TERAPIA DEL DOLORE DEL CANCRO DELLA MAMMELLA
No full textIl lavoro descrive i quadri dolorosi comuni nel cancro della mammella e il loro trattament
La neurolesione con radiofrequenza nel dolore cronico:la cura della nevralgia del trigemino
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Basic guide to chronic pain assessment: from neurophysiology to bedside
No full textChronic musculoskeletal pain is a highly prevalent condition that is commonly encountered in both general and specialist practice. Nonetheless, it still represents a significant challenge to the practitioners because of the lack of substantial evidence-based guidance. this review aimed to summarize the main pathophysiological mechanisms of chronic pain offering a mechanism-oriented approach to diagnosis and management. We believe that a basic knowledge of the physical signs and symptoms of these mechanisms could empower the clinician to choose appropriate medication and identify high-risk pain patients. Central sensitization and neuropathic features may arise in previously nociceptive and inflammatory pain syndromes. central sensitization is a functional remodeling of the spinal cord, where light touch afferents are recruited by nociceptive second-order neurons. Neuropathic features include both negative signs, such as reduced perception of vibration and touch, and positive symptoms, such as paroxysmal electric shock pain, due to ectopic discharge. These phenomena are the neurobiological basis of the commonly defined refractory chronic pain. early detection and specific treatment of these mechanisms are required in order to restrain the reinforcement of pronociceptive remodeling of the nervous system
Il ruolo dei blocchi anestetici nella diagnosi differenziale del dolore
No full textViene discusso il ruolo dei blocchi anestetici nella diagnosi differenziale del dolor
Editorial – Musculoskeletal pain: Which role for tapentadol?
Full text linkChronic pain is defined as pain persisting after healing of an underlying pathology or as persisting
pain in the absence of tissue damage. In the last decade, the understanding of mechanisms involved in
chronic pain led to an improved approach to patient management, with the aim to reduce discomfort,
improve quality of life (QoL) and enhance functional recovery.
Chronic musculoskeletal pain, which is frequently encountered in clinical practice, can affect patients
of all ages and is particularly common in older patients. Indeed, low back pain is the most frequent
chronic pain condition worldwide, with a lifetime prevalence of >70% in western countries1,2. Neck pain
is also a common disabling disease, with a prevalence of 23%, and is associated with high costs for medical visits and physiotherapy. Both low back pain and neck pain involve nociceptive and neuropathic
pain mechanism
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