139,763 research outputs found
"Filiz y Demophonte, poema tragico, por Antonio de Affonçeca Soares. Escripto por Abraham de Mesquita Pimentel."
No full textFiliz y Demophonte, poema tragico. Antonio de Affonceca SoaresContient : 1 El naufragio (86 octaves) ; 2 Las ruynas (72 octaves) ; 3 Los affectos (103 octaves) ; 4 Las selvas (91 octaves) ; 5 Los zelos (123 octaves) ; 6 La soledad (54 octaves) ; 7 Las lagrimas y los suspiros (87 octaves) ; 8 Las armas y los extremos (99 octaves)Numérisation effectuée à partir d'un document de substitutionCet exemplaire du poème d'Antonio da Fonseca Soares (en religion : Fr. Antonio das Chagas) contient huit chants
Filiz Subaşi, Doğa - Cano, María José (2021) Las Azharot de Selomoh Ibn Gabirol
Full text linkFiliz Subaşi, Doğa - Cano, María José (2021) Las Azharot de Selomoh Ibn Gabirol. Versión hebrea con traducción al castellano, y judeoespañola con transcripción. Prólogo e introducción. Granada: In Loco Nativola, 96 pp. ISBN: 978840929642
Do the quantitative relationships of synaptic junctions and terminals in the thalamus of genetic absence epilepsy rats from Strasbourg (GAERS) differ from those in normal control Wistar rats
No full textAbnormal functional properties of the thalamocortical connections were reported in the absence of epilepsy. The present study compares the ratios of terminals (`RL'-round vesicles, large terminals, 'RS'-round vesicles, small terminals and 'F'-flattened vesicles) and synapse in three first-order (ventrobasal, lateral geniculate and anteroventral) and in three higher-order (posterior, lateral posterior and mediodorsal) thalamic nuclei of genetic absence epilepsy rats from Strasbourg (GAERS) with our earlier quantitative studies of normal Wistar rats to show whether quantitative differences were present in GAERS as compared to Wistar rat. Rats were perfused transcardially, the brains were removed and cut as 300 lmcoronal sections. Parts of the six thalamic nuclei were removed for routine electron microscopy and GABA immunocytochemistry. Twenty photographs from each section at 20,0009 magnification were taken, and the terminals were identified as RL, RS or F. (1) In normal Wistar rats (as in cats), the proportion of driver terminals (RL) and synapses is lower in higherorder than in first-order thalamic nuclei, but this difference is not present in GAERS animals. (2) The proportions of RS terminals and synapses for each thalamic nucleus showed no significant differences between GAERS and Wistar rats for any of the thalamic nuclei. (3) In GAERS, the proportion of inhibitory F terminals and synapses was significantly high in the VB and low in the LP thalamic nucleus. These abnormal ratios in the GAERS may be the cause of the spike-and-wave discharges of absence seizures or may represent a compensatory response of the thalamocortical circuitry to the absence seizures
Prediction of cyclosporine A blood levels: an application of the adaptive-network-based fuzzy inference system (ANFIS) in assisting drug therapy
No full textObjective Therapeutic drug monitoring (TDM) is a procedure in which the levels of drugs are assayed in various body fluids with the aim of individualizing the dose of critical drugs, such as cyclosporine A. Cyclosporine A assays are performed in blood. Methods We proposed the use of the Takagi and Sugeno-type adaptive-network-based fuzzy inference system (ANFIS) to predict the concentration of cyclosporine A in blood samples taken from renal transplantation patients. We implemented the ANFIS model using TDM data collected from 138 patients and 20 input parameters. Input parameters for the model consisted of concurrent use of drugs, blood levels, sampling time, age, gender, and dosing intervals. Results Fuzzy modeling produced eight rules. The developed ANFIS model exhibited a root mean square error (RMSE) of 0.045 with respect to the training data and an error of 0.057 with respect to the checking data in the MATLAB environment. Conclusions ANFIS can effectively assist physicians in choosing best therapeutic drug dose in the clinical setting
An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial
No full textBackground: Triester glycerol oxide gel (Protefix (R) Queisser Pharma, Germany) is a new topical agent that has the property of adherence to the oral mucosa by forming a lipid film which protects against mechanical trauma and may help to reduce oral tissue moisture loss and inflammation. The aim of this clinical trial was to determine the efficacy of a topical TGO gel and to also compare it with triamcinolone acetonide pomade in the treatment of minor recurrent aphthous stomatitis. Material and Methods: This study was a randomized, double-blind, placebo-controlled clinical trial and 180 patients with the complaint of minor aphthous ulcers were enrolled in this study. The sociodemographic data and clinical characteristics of the ulcer were collected by questionnaire. Ulcer size and pain level measurements were performed and the efficacy indices for ulcer pain and size were calculated at day 0,2,4,6 by the same investigator. Results: Significant differences were not detected among the demographics and ulcer histories including age, gender, onset of ulcer, mean healing time, family RAS history and ulcer localization between three groups. The pain score in TGO group was found statistically lower at day 2,4, and 6. Efficacy index and improvement rate of TGO group, regarding pain score, was higher than the other two groups at day 2 and 4. The reduction in ulcer size was statistically higher in TGO group than the other two groups at day 4 and 6. Conclusions: Topical application of TGO gel could decrease pain intensity, accelerate ulcer healing without any side effects, utilizing an easy appliable and accessible procedure. Therefore TGO gel could be a well-tolerated, safe, topical therapeutic agent in the clinical practice of RAS treatment
Suppressive effect of Rho-kinase inhibitors Y-27632 and fasudil on spike-and-wave discharges in genetic absence epilepsy rats from Strasbourg (GAERS)
No full textRho/Rho-kinase (ROCK) signaling contributes to neuroinflammation, epileptogenesis, and seizures in convulsive-type epilepsies. However, this pathway has not been investigated in absence epilepsy. We investigated RhoA activity in genetic absence epilepsy rats from Strasburg (GAERS) and the effects of ROCK inhibitors Y-27632 and fasudil on spike-and-wave discharges (SWDs) of GAERS. ROCK level and activity were measured by Western blot analysis in the brain areas involved in absence seizures (i.e., cortex and thalamus) and hippocampus. Male GAERS were stereotaxically implanted with bilateral cortical electrodes for electroencephalogram (EEG) recordings and/or guide cannula into the right ventricle. ROCK inhibitors were administered by intraperitoneal injection (1-10mg/kg for Y-27632 or fasudil) or intracerebroventricular injection (7-20nmol/5l for Y-27632 or 10-100nmol/5l for fasudil). EEG was recorded under freely moving conditions. Compared with Wistar rats, GAERS exhibited increased RhoA activity in the somatosensory cortex but not in the thalamus or hippocampus. The single systemic administration of Y-27632 and fasudil partially suppressed the duration and frequency of absence seizure, respectively. However, local brain administration caused a widespread suppressive effect on the total seizure duration, number of seizures, and the average individual seizure length. In summary, Rho/ROCK signaling may be involved in the pathophysiology of absence epilepsy. Furthermore, ROCK inhibitors can control the expression of absence seizure in GAERS, thus indicating that Y-27632 and fasudil have the potential to be used as novel anti-absence drugs
The Role of Rho/Rho-Kinase Pathway in the Pathophysiology of Absence Epilepsy
No full textObjectives: Rho/Rho-kinase (ROCK) signaling has been shown to contribute to neuroinflammation, epileptogenesis, and seizures in convulsive-type epilepsy models. However, this pathway has not been investigated in the pathophysiology of absence epilepsy. The aim of this study was to investigate ROCK activity in brain regions involved in spike-and-wave discharge (SWD) generation and the effects of the Rho-kinase inhibitor, Y-27632, on ROCK activity in genetic absence epilepsy rats from Strasburg (GAERS). Methods: ROCK activity in the somatosensorial cortex, hippocampus, and thalamus was measured using an enzyme-linked immunosorbent assay (ELISA). An intracerebroventricular (i.c.v.) injection of Y-27632 was administered at a dose of 20 nmol/5 mu l and changes in ROCK activity were assessed. To evaluate the effect of Y-27632 on SWDs, i.c.v. 20 nmol and 60 nmol doses of Y-27632 were administered to the GAERS subjects and electroencephalography was performed. Results: ROCK activity was elevated in the somatosensory cortex in the GAERS study subjects, and the Rho-kinase enzyme inhibitor, Y-27632, suppressed this increase. In addition, Y-27632 significantly reduced the total and mean duration of SWDs compared with the control group. Conclusion: The findings indicate that the Rho-kinase pathway may play a role in the generation of absence seizures, and that the suppressive effect of Y-27632 on SWDs may be a potential therapeutic target for this anti-absent effect
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
Detection of virus and phytoplasma infections in carrot cultivation areas of Ankara and Konya provinces and determination of inoculum sources
No full textBu çalışmada Ankara ve Konya illeri havuç ekim alanlarında fitoplazmaların ve virüslerin varlığı ile inokulum kaynakları araştırılmıştır. Havuç ekim alanlarında yoğun olarak bitkinin kök ve yaprak kalitesini etkileyen sararmalara, kızarmalara ve kökler de şekil bozukluklarına neden olabilen fitoplazmalar ile Carrot virus Y (CtVY), Carrot red leaf virus (CtRLV), Carrot red leaf associated virus-RNA (CtRLVaRNA), Carrot mottle virus (CMoV), Carrot torradovirus 1 (CaTV), Carrot yellow leaf virus (CYLV), Carrot thin leaf virus (CTLV) ve Cucumber mosaic virus (CMV) etmenleri konvansiyonel moleküler teknikler kullanılarak araştırılmıştır. Araştırma konusu bölgelerde 2018-2020 yılları arasında peryodik arazi çalışmaları yapılarak, 272 havuç örneği, 19 yabancı ot, 8 havuç tohumu ve 45 böcek örneği toplanmıştır. Toplanan bitki örneklerinden yapılan RT-PCR analizlerinde herhangi bir viral etmen tespit edilememiş bu nedenle fitoplazma enfeksiyonları da araştırmaya dahil edilmiştir. Havuç örneklerinde yaygın olarak 16SrVI-A 'Candidatus Phytoplasma trifolii' ve 16SrI-B 'Aster yellows' altgrupları moleküler olarak ve in vitro/ in silico RFLP kesim analizleri ile belirlenmiştir. Ayrıca fitoplazma inokulum kaynağı olarak tohum, yabancı ot ve vektör böceklerinde 16SrVI ve 16SrI grupları ile bulaşık olduğu tespit edilmiştir. Bu çalışma ile ülkemiz havuç ekim alanlarında ilk defa 16SrVI ve 16SrI gruplarının şiddetli enfeksiyonlara neden olduğu belirlenmiştir. Ayrıca 16SrVI ve 16SrI enfekteli yabancı ot, tohum ve böcek vektörlerden elde edilen bulgular bilgilerimize göre ülke için ilk kayıt niteliği taşımaktadır.In this study, the presence of phytoplasmas and viruses and their inoculum sources were investigated in the carrot cultivation areas of Ankara and Konya provinces. Phytoplasmas, Carrot virus Y (CtVY), Carrot red leaf virus (CtRLV), Carrot red leaf associated virus-RNA (CtRLVaRNA), Carrot mottle virus (CMoV), Carrot torradovirus 1 (CaTV), Carrot yellow leaf virus (CYLV), Carrot thin leaf virus (CTLV), and Cucumber mosaic virus (CMV) agents, which can cause yellowing, redness and root deformities/abnormalities, which affect the root and leaf quality of the plant intensively in carrot cultivation areas, were investigated. Periodic field studies were conducted in these regions between 2018 and 2020, and 272 carrot samples, 19 weeds, 8 carrot seeds and 45 insects were collected. Viral agents under search were not detected in the RT-PCR analyzes performed within the scope of this study, therefore phytoplasma infections were also included in the study. 16SrVI-A 'Candidatus phytoplasma trifolii' and 16SrI-B 'Aster yellows' subgroups were determined molecularly and by in vitro/in silico RFLP digestion analyses. In addition, seeds, weeds and vector insects as a source of phytoplasma inoculum were found to be contaminated with 16SrVI and 16SrI groups. In this study, it was determined for the first time that 16SrVI and 16SrI groups cause severe infections in the carrot fields of our country. According to our knowledge the results obtained from 16SrVI and 16SrI infected weed, seed and insect vectors are the first record for our country
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