186,390 research outputs found
Data for:Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males
No full textRaw values from measurements of environmental chemicals, transcript and protein markers of exposure and lipids in livers from sheep continuously exposed in pastures fertilised by control or sewage sludge fertilise
Epidemiologia, cl?nica e evolu??o de rec?m-nascidos com s?filis cong?nita
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Previous issue date: 2011-03-28OBJETIVO: Estudar a epidemiologia, os aspectos cl?nicos e a evolu??o de crian?as que tiveram diagn?stico de s?filis cong?nita e receberam tratamento no per?odo neonatal, assim como daquelas cujas m?es tiveram s?filis gestacional e foram tratadas durante a gesta??o. M?TODOS: A amostra, de conveni?ncia, foi composta por todos os rec?m-nascidos vivos cujas m?es tinham sorologia positiva para s?filis na gesta??o e/ou no parto, nascidos no Hospital S?o Lucas da PUCRS (HSL) no per?odo de maio de 1997 a dezembro de 2004. Adicionalmente, foram inclu?dos rec?m-nascidos com s?filis cong?nita provenientes de outros hospitais. No per?odo do estudo, todos os pacientes foram encaminhados para acompanhamento de rotina no Ambulat?rio de Infec??es Cong?nitas do HSL. Para avaliar a nutri??o, calculamos a percentagem da mediana do peso final para cada paciente, tomando como refer?ncia os gr?ficos de peso sobre idade da Organiza??o Mundial da Sa?de. Os dados foram coletados prospectivamente, digitados e analisados no Epi Info, vers?o 3.4. Os resultados foram expressos em frequ?ncias percentuais e tamb?m foram utilizados os testes Qui-quadrado (ou exato de Fisher quando indicado) para associa??es e o Mann-Whitney/Wilcoxon para compara??o entre m?dias. O n?vel de signific?ncia adotado foi P<0,05. RESULTADOS: No per?odo do estudo ocorreram 24.920 partos de rec?m-nascidos vivos no HSL e 499 m?es tiveram diagn?stico de s?filis. Em 120 casos as m?es haviam recebido tratamento correto para s?filis antes do parto (grupo SM). No mesmo per?odo, 379 nascidos vivos preencheram os crit?rios de defini??o de caso de s?filis cong?nita (grupo SC-HSL) A preval?ncia de s?filis cong?nita foi de 15,2 casos por 1000 nascidos vivos (IC 95% 14-17/1000). Mais 19 casos de rec?m-nascidos com s?filis, procedentes de outros hospitais, foram inclu?dos na amostra, somando 398 pacientes com s?filis cong?nita (grupo SC). Assim, a amostra total do estudo incluiu 518 pacientes. No grupo SC-HSL 5,0% dos rec?m-nascidos tinham idade gestacional inferior a 34 semanas, em compara??o a 0,8% no grupo SM (p<0,05). No grupo SC-HSL a m?dia do peso de nascimento foi de 2979g (?632g) e a mediana foi 3057g (amplitude interquartil 2670-3335g, m?n. 610g, m?x. 4870g). No grupo SM a m?dia foi de 3243g (?522g) e a mediana foi 3227g (amplitude interquartil 2882-3590g, m?n. 1830g, m?x. 4645g) (P<0,001). Os pequenos para a idade gestacional foram 5/120 (4,2%) no grupo SM e 44/379 (11,6%) no grupo SC-HSL (P<0,005). Analisando-se apenas os pacientes do grupo SC-HSL, houve associa??o entre presen?a de manifesta??es cl?nicas e prematuridade: OR=3,0 (IC 95% 2,5-6,0). 11 Dos 398 rec?m-nascidos com s?filis cong?nita, 389 tiveram alta e 9 (2,3%) foram a ?bito na UTI Neonatal. Ocorreu um ?bito neonatal no grupo SM e foram identificados dois ?bitos ap?s o per?odo neonatal. Dos 508 pacientes que tiveram alta, 256 (50,3%) retornaram ao HSL para pelo menos uma consulta. Para avaliar o crescimento e as poss?veis sequelas, selecionamos apenas os pacientes que puderam ser examinados com pelo menos 8 meses de idade, perfazendo 120 pacientes do grupo SC e 27 do grupo SM. A mediana da percentagem da mediana do peso final no grupo SC foi 102,5 (amplitude interquartil 92-113, m?n 52, m?x 158) e no grupo SM foi 108 (amplitude interquartil 103-116, m?n 85, m?x 125); P<0,05. Excluindo-se os prematuros, a diferen?a continuou significativa: grupo SC 103 (amplitude interquartil 94-113,5 m?n 52, m?x 158) e grupo SM 109 (amplitude interquartil 104-120, m?nimo 97, m?ximo 125); P<0,05. Dos 120 pacientes do grupo SC que foram examinados com pelo menos 8 meses, 16 (13,3%) apresentavam alguma sequela relacionada com a s?filis ou com a prematuridade (excluindo-se os que apresentavam apenas baixo peso). Nenhum dos 24 pacientes do grupo SM apresentava sequelas; P<0,05. Para comparar os 120 pacientes com s?filis cong?nita entre os com e sem sequelas em rela??o ao quadro cl?nico inicial (no per?odo neonatal), inclu?mos apenas os 95 que tiveram quadro cl?nico conclusivo. Havia manifesta??es cl?nicas no per?odo neonatal em 13 (92,9%) dos 14 com sequelas e em 31(38,3%) dos 81 sem sequelas. OR=20,9 (IC95% 2,6-168,3). CONCLUS?ES: As associa??es encontradas refletem a grande morbidade da s?filis cong?nita, principalmente nas mais precoces da gesta??o. Concluimos que a defini??o de caso atual, embora possa ter uma sensibilidade exagerada, est? sendo altamente eficiente em identificar os rec?m-nascidos que n?o tem chance de estar infectados e apontar os rec?m-nascidos em risco de s?filis cong?nita, que n?o devem ter alta sem tatamento. Apesar do baixo ?ndice de retorno, o estudo conseguiu mostrar que a s?filis cong?nita continua sendo uma doen?a de grande impacto, causando prematuridade, baixo peso, mortes neonatais, sequelas graves e irrevers?veis nos rec?m-nascidos que sobreviveram, e as sequelas s?o mais frequentes nos rec?m-nascidos cujo tratamento foi iniciado mais tardiamente. Por outro lado, a maioria dos rec?m-nascidos com s?filis cong?nita, mesmo apresentando manifesta??es cl?nicas no per?odo neonatal, respondem muito bem ao tratamento iniciado precocemente, evoluindo de forma satisfat?ria, desde que satisfeitas as condi??es ambientais b?sicas para seu crescimento e desenvolvimento
De la hermosura de Filis
No full textEste trabajo se inscribe dentro del Proyecto de Investigación «Digital “Música Poética”. Base de datos integrada del Teatro Clásico Español» (FFI2015-65197-C3-2-P) (MINECO/FEDER, UE).El documento contiene la composición a cuatro voces titulada “De la hermosura de Filis” del compositor Manuel Machado y poeta anónimo, perteneciente al Libro de Tonos Humanos (LTH, nº 170), cancionero poético-musical del siglo XVII que se conserva en la Biblioteca Nacional de España (BNE) bajo la signatura M/1262. Se ofrece la transcripción a notación moderna de la música, el texto poético debidamente puntuado y con algunas notas a los versos, varios datos de interés musical y musicológico, y la crítica de la edición cuando es necesario. Esta composición forma parte de la edición completa de este importante cancionero que llevan a término Lola Josa (filóloga) y Mariano Lambea (musicólogo).Consejo Superior de Investigaciones Científicas (CSIC)Universitat de Barcelona (UB)N
No hay que dormirse Filis
No full textEste trabajo se inscribe dentro del Proyecto de Investigación «Digital “Música Poética”. Base de datos integrada del Teatro Clásico Español» (FFI2015-65197-C3-2-P) (MINECO/FEDER, UE).El documento contiene la composición a cuatro voces titulada “No hay que dormirse, Filis” de compositor y poeta anónimos, perteneciente al Libro de Tonos Humanos (LTH, nº 169), cancionero poético-musical del siglo XVII que se conserva en la Biblioteca Nacional de España (BNE) bajo la signatura M/1262. Se ofrece la transcripción a notación moderna de la música, el texto poético debidamente puntuado y con algunas notas a los versos, varios datos de interés musical y musicológico, y la crítica de la edición cuando es necesario. Esta composición forma parte de la edición completa de este importante cancionero que llevan a término Lola Josa (filóloga) y Mariano Lambea (musicólogo).Consejo Superior de Investigaciones Científicas (CSIC)Universitat de Barcelona (UB)N
As gesta??es subsequentes em mulheres que tiveram s?filis na gesta??o
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Previous issue date: 2014-08-18Importance: Many efforts have ocurred in identify risk factors and causes of congenital syphilis (CS) persistence along years, and in many cases, the repetition of the condition in the same woman. In Rio Grande do Sul, there are no studies about the reincidence of CS, its causes and outcomes.
Objectives: To investigate the next pregnancies in women who already had syphilis in a previous pregnancy.
Methods: The study sample were women with obstetrical events ocurred in S?o Lucas Hospital (SLH) between may 1997 and december 2004. We included all patients with syphilis before or during pregnancy who had newborns, stillborns or abortions with CS, as patients correctly treated for syphilis before delivery and that had newborns without syphilis. The CS cases were defined according to the Brazilian Ministry of Health (appendix 1). The follow-up period for the subsequent pregnancies was until december 2011. The data were analised in program Epi Info 3.4, using the χ? test or Fisher exact test for associations, and Mann-Whitney-Wilcoxon test for comparison of medians. The level of significance was set at p < 0,05.
Results: We identified 450 women with positive tests for syphilis that had at least one obstetrical event in SLH between may 1997 and december 2004, within 166 had at least one more obstetrical event in the same hospital until december 2011.Cases of CS were 82% in the initial events and 68,5% in the subsequent s (OR 2,09, CI95% 1,3-3,3). Within patients with CS in the initial event, 72% had at least one more pregnancy with CS, against 56,6% of patiens without CS in the initial event(OR 1,97, CI95% 0,9-4,4).
Conclusions: Many cases of CS with adverse outcomes ocurred in the subsequent pregnancies, although less than in the initial events. It is suspected that more uninfected newborns may have been defined as cases of congenital syphilis in subsequent pregnancies, because of the lack of records of maternal history and the absence or inadequacy of prenatal care. It is important to increase surveillance on women who have already had one pregnancy with syphilis.Import?ncia: Muitos esfor?os t?m ocorrido em identificar os fatores de risco e as causas da persist?ncia da s?filis cong?nita (SC) ao longo dos anos, e muitas vezes a repeti??o de casos em uma mesma mulher. No Rio Grande do Sul, ainda n?o existe um estudo sobre a reincid?ncia da SC, suas causas e seus desfechos.
Objetivos: Investigar as gesta??es subsequentes em mulheres que tiveram s?filis na gesta??o.
Material e m?todos: A popula??o de estudo foram as pacientes atendidas no Centro Obst?trico do HSL cujos eventos obst?tricos ocorreram entre maio de 1997 e dezembro de 2004. Foram inclu?das todas as pacientes que tiveram s?filis antes ou durante a gesta??o e tiveram rec?m-nascidos vivos, abortos ou natimortos com s?filis cong?nita, assim como pacientes adequadamente tratadas para s?filis antes do parto, que deram ? luz rec?m-nascidos vivos sem s?filis cong?nita. Os casos de s?filis cong?nita foram definidos conforme os crit?rios do Minist?rio da Sa?de (anexo 1). O levantamento das gesta??es subsequentes incluiu o per?odo at? dezembro de 2011. Os dados foram analisados no programa Epi Info 3.4, utilizando-se o teste de χ? ou teste exato de Fisher para associa??es, e o teste Mann-Whitney-Wilcoxon para compara??es de medianas. O n?vel de signific?ncia foi estabelecido como p < 0,05.
Resultados: Foram identificadas 450 mulheres com testes positivos para s?filis com pelo menos um evento obst?trico no HSL entre maio de 1997 e dezembro de 2004, das quais 166 tiveram pelo menos mais um evento subsequente no mesmo hospital at? dezembro de 2011. Os casos de SC foram de 82% nos eventos iniciais e 68,5% nos subsequentes (OR 2,09, IC95% 1,3-3,3). Entre as pacientes com SC no evento inicial, 72% tiveram pelo menos mais um evento com SC, contra 56,6% das pacientes sem SC no evento inicial (OR 1,97, CI95% 0,9-4,4).
Conclus?es: Ocorreram muitos de casos de SC com desfechos adversos nas gesta??es subsequentes, embora em menor n?mero do que nas iniciais. Suspeita-se que mais rec?m-nascidos n?o infectados possam ter sido definidos como casos de s?filis cong?nita nas gesta??es subsequentes, em virtude da falta de registros dos antecedentes maternos e da aus?ncia ou inadequa??o do acompanhamento pr?-natal. ? importante aumentar a vigil?ncia sobre as mulheres que j? tiveram uma gesta??o com s?filis
Macro economy, stock market and oil prices: Do meaningful relationships exist among their cyclical fluctuations?
No full textThis paper examines the relationship among consumer price index, industrial production, stock market and oil prices in Greece. Initially we use a unified statistical framework (cointegration and VECM) to study the data in levels. We then employ a multivariate VAR model to examine the relationship between the cyclical components of our series. The period of the study is from 1996:1 – 2008:6. Findings suggest that oil prices and the stock market exercise a positive effect on the Greek CPI, in the long run. Cyclical components analysis suggests that oil prices exercise significant negative influence to the stock market. In addition, oil prices are negatively influencing CPI, at a significant level. However, we find no effect of oil prices on industrial production and CPI. Finally, no relationship can be documented between the industrial production and stock market for the Greek market. The findings of this study are of a particular interest and importance to policy makers, financial managers, financial analysts and investors dealing with the Greek economy and the Greek stock market
Roles of PLCβ1 in female reproduction
No full textIn mammals, development of a new organism requires fertilisation of the female
egg by sperm. The resulting zygote develops into the blastocyst stage as it travels
towards the uterus. Within the uterus, the blastocyst invades the maternal tissues
and establishes access to the maternal blood supply. This process is called
implantation and is absolutely essential for the further development of the
conceptus and establishment of pregnancy. Successful implantation requires a
proper preparation of the uterus and the embryo as well as a molecular dialogue
between the embryo and the uterine tissues.
Female mice that have a disruption in the Plcβ1 gene are infertile. In the course of
this Thesis it became apparent that the main cause of their infertility is their
inability to implant their embryos. PLCβ1 protein is a mediator of G-protein
coupled receptor (GPCR) signalling and it is involved in the production of second
messengers essential for downstream transmission of signals. A host of
reproductive functions are under the control of GPCR signalling. In this PhD
Thesis the infertile phenotype of Plcβ1 knockout (KO) female mice was
investigated to identify the reproductive processes affected by the lack of a
functional PLCβ1 protein. A combination of histological, molecular biology and in
vivo techniques were utilised to show that at the time of implantation, embryos fail
to attach to the uterine epithelium of KO uteri. In addition, it was demonstrated
that estrogen signalling and components of the endocannabinoid metabolism, both
key processes for successful implantation are severely altered in KO uteri. These
observations show that KO uteri fail to prepare for implantation. In addition, the
KO reproductive tract exerts a detrimental effect on pre- and peri- implantation
embryo development.
Currently, failure of implantation is thought to be one of the major causes of
infertility in women and up to this date there are no successful treatments. The results of this project expand our current knowledge on the physiology of
implantation and provide cues for the development of diagnostic markers and
treatments for the women who are unable to conceive
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Oil price shocks and stock market returns: New evidence from the United States and China
No full textThis study examines the time-varying correlations between oil prices shocks of different types (supply-side, aggregate demand and oil-market specific demand as per Kilian (2009) who highlighted that "Not all oil shocks are alike") and stock market returns, using a Scalar-BEKK model. For this study we consider the aggregate stock market indices from two countries, China and the US, reflecting the most important developing and developed financial markets in the world. In addition to the whole market, we also consider correlations from key selected industrial sectors, namely Metals & Mining, Oil & Gas, Retail, Technology and Banking. The sample period runs from 1995 until 2013. We highlight several key points: (i) correlations between oil price shocks and stock returns are clearly and systematically time-varying; (ii) oil shocks of different types show substantial variation in their impact upon stock market returns; (iii) these effects differ widely across industrial sectors; and finally (iv) China is seemingly more resilient to oil price shocks than the US
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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