10,696,949 research outputs found
Introduction to Gabriel Filippelli & His Work
No full textVideo available at: https://media.dlib.indiana.edu/media_objects/jq086b55sVideo available at: https://youtu.be/o-eMsLhL4zQ?si=HgJCxhrGWUA9GKeQIn this video, Dr. Filippelli discusses his work with community partners to address environmental toxicity concerns in their neighborhoods
Il destino della responsabilità sanitaria tra intelligenza artificiale e software predittivi
No full textLA RESPONSABILITÀ SANITARIA II edizione L’evoluzione storica e l’attuale normativa La responsabilità penale, civile, amministrativa e contabile Il danno Gli aspetti procedimentali e deontologici
No full textLa reproducción sin autorización de obras en Internet : el turno de los libros
No full textFil: Filippelli, Gerardo. Universidad de Buenos Aires. Facultad de Derecho. Buenos Aires, ArgentinaFil: Filippelli, Gerardo. Universidad de Barcelona. Facultad de Economía y Empresa. Barcelona, EspañaTema: Derecho de autor : cuestiones actuales / Delia Lipszyc, coord. -
2-aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity
No full textA series of 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles was synthesized and tested for antiarrhythmic, local
anaesthetic and analgesic activity. The title compounds showed a good antinociceptive activity
El discurso de Cambiemos en clave de campaña : nuevas estéticas en el espectáculo político
No full textFil: Filippelli, Nerina. Universidad Nacional de Villa María; Argentina
Adrenoreceptors and nitric oxide in the cardiovascular system
No full textNitric Oxide (NO) is a small molecule that continues to attract much attention from the scientific community. Since its discovery, it has been evident that NO has a crucial role in the modulation of vascular tone. Moreover, NO is involved in multiple signal transduction pathways thus contributing to the regulation of many cellular functions. NO effects can be either dependent or independent on cGMP, and rely also upon several mechanisms such as the amount of NO, the compartmentalization of the enzymes responsible for its biosynthesis (NOS), and the local redox conditions. Several evidences highlighted the correlation among adrenoreceptors activity, vascular redox status and NO bioavailability. It was suggested a possible crosstalk between NO and oxidative stress hallmarks in the endothelium function and adaptation, and in sympathetic vasoconstriction control. Adrenergic vasoconstriction is a balance between a direct vasoconstrictive effect on smooth muscle and an indirect vasorelaxant action caused by α2- and β-adrenergic endothelial receptor-triggered NO release. An increased oxidative stress and a reduction of NO bioavailability shifts this equilibrium causing the enhanced vascular adrenergic responsiveness observed in hypertension. The activity of NOS contributes to manage the adrenergic pathway, thus supporting the idea that the endothelium might control or facilitate β-adrenergic effects on the vessels and the polymorphic variants in β2-receptors and NOS isoforms could influence aging, some pathological conditions and individual responses to drugs. This seems to be dependent, almost in part, on differences in the control of vascular tone exerted by NO. Given its involvement in such important mechanisms, the NO pathway is implicated in aging process and in both cardiovascular and non-cardiovascular conditions. Thus, it is essential to pinpoint NO involvement in the regulation of vascular tone for the effective clinical/therapeutic management of cardiovascular diseases (CVD). © 2013 Conti, Russomanno, Corbi, Izzo, Vecchione and Filippelli
- …
