550 research outputs found
Editorial [Hot Topic: Choosing between Targeted Therapies for Rheumatoid Arthritis Patients (Guest Editor: Filip De Keyser)]
No full textAssociation Between Nursing Support Levels and Effectiveness of Golimumab in the Management of Patients with Rheumatologic Diseases
No full textIntroduction The main objective of this study was to assess the level of nursing support received by biologic-naive rheumatological patients treated with golimumab during their first cycle. Methods Adult patients (N = 119; aged 46.9 +/- 13.4 years (mean +/- standard deviation); 49.6% males), with rheumatoid arthritis (N = 40), ankylosing spondylitis (N = 58) or psoriatic arthritis (N = 21), and treated with golimumab (first tumor necrosis factor-alpha inhibitor) during a first reimbursement cycle were included by 17 Belgian centers. Patients were categorized in three levels of nursing support (intense, medium, or low). They filled in a non-validated and exploratory questionnaire about satisfaction, quality, and helpfulness of information. Results The nursing support was considered intense, medium, or low for 98 (82.4%), 10 (8.4%), and 11 (9.2%) patients, respectively. All disease activity scores improved versus baseline, and 90% of the patients qualified for treatment prolongation without major differences between nursing level groups. The proportion of patients able to self-inject golimumab was 88, 90, and 73% in the intense, medium, and low support groups, respectively. Satisfaction was high in all three nursing support groups. Conclusions This prospective open-label study has confirmed the short-term effectiveness of golimumab in three rheumatological diseases, with most of the patients qualifying for reimbursement renewal. The limited sample size and the fact that the vast majority of patients benefited from an intense nursing support did not allow drawing definite conclusions concerning the impact of the nursing level on the treatment effectiveness and changes in the disease activity. Nurses seem however to play a crucial role in this short-term study but this remains to be confirmed in a longer-term study
Evaluatie van activiteitenbeperkingen bij personen met reumatoïde artritis in het kader van de bestaande wettelijke referentiekaders in België
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Microgel diffusieblotting : toepassing van de techniek bij de evaluatie van de serologische antinucleaire immuniteit bij patiënten met reumatische aandoeningen
No full textEvaluatie ARMAX E10-predictie model
No full textNa jaren van onderzoek en ontwikkeling is in 1986 op het Hydro Meteo Centrum (HMC) in Zeeland een tijdreeksmodel geïmplementeerd, waarmee m.b.v. aktuele golf- en windwaarnemingen deiningsvoorspellingen voor de zuidelijke Noordzee gegenereerd kunnen worden. De laagfrequente energie (E10) voorspellingen van dit ARMAX model zijn in principe gebaseerd op deiningsvoortplanting vanuit het noorden (Schilperoort, Poulisse en Wensink, zie Appendix I) en worden voornamelijk gebruikt om een optimaal toelatingsvoorschrift voor de toegangsgeulen van de Rotterdamse havens te verkrijgen. Verder worden ze gebruikt bij werkzaamheden voor de Oosterscheldekering en bij de toelating van schepen in de Westerschelde. Een eerste versie van dit model is geëvalueerd om inzicht te krijgen in de voorspelkracht van ARMAX voor verschillende situaties. Daartoe zijn voor een periode van 10 maanden verschillende voorspellingen met metingen vergeleken. Het resultaat bestaat uit statistisch vergelijkingsmateriaal, aangevuld met casestudy's van geselecteerde stormperiodes.vloeistofmechanicaHydraulic EngineeringCivil Engineering and Geoscience
Autoantibodies in rheumatology practice : relevance for diagnosis and associations with clinical features
No full textDiss. doct. medische wetenschappe
Instrumentos conceptuais e metodológicos na análise de riscos e nos processos de prevenção: a abordagem de Véronique De Keyser
No full textWe present the conceptual and methodological approach proposed by Véronique De Keyser to managing prevention and analysing professional risks. In this perspective conceptions and practices of prevention should always emerge and be structured by the risk analysis accomplished in context and with the participation of the concerned actors. We have structured the presentation of this approach in three parts. We begin by analysing the evolution of paradigms that support the understanding of risk evaluation and prevention management. Next we operationalise the concepts and the theories that characterise the contextual approach envisaged by the author to research/intervention in this domain. We conclude with the exposition of the most widespread methods in risk evaluation study, emphasising their use as instruments in order to promote transformations in views on conceptions and practices of prevention
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