323,215 research outputs found
BRAF mutation assessment in papillary thyroid cancer: Are we ready to use it in clinical practice?
No full textMany features of BRAF oncogene in papillary thyroid cancer have been elucidated. Many aspects still need to be clarified through prospective and randomized studies. However, BRAF mutation status in thyroid cancer appears as a promising marker to provide a basis for developing a personalized managemen
Sonographically estimated thyroid nodule malignancy risk: Strengths and limitations in clinical practice
No full textn recent years, the clinical relevance of thyroid ultra-sound has increased. Due to the development of risk-strati-fication systems that use a systematic assessment of thyroid nodule sonographic characteristics and tiered categories, such as the Thyroid Imaging Reporting and Data System (TI-RADS), a pattern of morphologic features is easily translated into a specific class, with an associated estimate of malignancy risk and suggestions for clinical manage-men
"A 5-year study to compare the durability of glycemic control of a combination regimen with vildagliptin & metformin versus standard-of-care monotherapy with metformin, initiated in treatment-naïve patients with type 2 diabetes mellitus"
No full textThyroid-hormone therapy and thyroid cancer: a reassessment
No full textExperimental studies and clinical data have demonstrated that thyroid-cell proliferation is dependent on thyroid-stimulating hormone (TSH), thereby providing the rationale for TSH suppression as a treatment for differentiated thyroid cancer. Several reports have shown that hormone-suppressive treatment with the L-enantiomer of tetraiodothyronine (L-T-4) benefits high-risk thyroid cancer patients by decreasing progression and recurrence rates, and cancer-related mortality. Evidence suggests, however, that complex regulatory mechanisms (including both TSH-dependent and TSH-independent pathways) are involved in thyroid-cell regulation. Indeed, no significant improvement has been obtained by suppressing TSH in patients with low-risk thyroid cancer. Moreover, TSH suppression implies a state of subclinical thyrotoxicosis. In low-risk patients, the goal of L-T-4 treatment is therefore to obtain a TSH level in the normal range (0.5-2.5 mU/1). Only selected patients with high-risk papillary and follicular thyroid cancer require long-term TSH-suppressive doses of L-T-4. In these patients, careful monitoring is necessary to avoid undesirable effects on bone and heart
Research design and writing of scholarly articles: new artificial intelligence tools available for researchers
No full textRecent advances in artificial intelligence (AI) have introduced transformative capabilities that are revolutionizing the process of scientific research and communication. AI tools can assist researchers in designing studies, analyzing data, and drafting manuscripts, enhancing both efficiency and analytical rigor. This allows researchers to focus cognitive resources on higher-level conceptualization and interpretation. Furthermore, AI holds promise for steering research towards more impactful directions by aiding in the identification of critical knowledge gaps and research questions with potential societal benefits. Collaboration platforms powered by AI facilitate connections between researchers across domains and institutions, accelerating discovery and promoting convergence around global health priorities. However, responsible development and application of AI in research is essential. Transparency, explainability, data privacy, and human oversight must remain priorities to ensure ethical AI practices. While AI offers transformative capabilities, researchers must maintain agency and responsibility over the scientific process. With thoughtful governance and participatory design, AI can become a powerful tool for advancing science in the service of society. Overall, AI ushers in new potentials for improving the rigor, relevance, and reach of scientific inquiry. Yet realization of this potential necessitates proactive efforts to address emerging risks and challenges
Health as a human right, the right to life and the freedom to choose
No full textIn a work recently published in an important international journal of medical oncology one of the most relevant names in the field of palliative care and pain therapy in Italy, reiterated once again the importance of a good end of life for cancer patients. All this in light of a recent ruling by the Italian Constitutional Court on the decriminalization decision in case of support for suicide in particular conditions, inviting the Parliament to legislate on the delicate issue concerning assisted suicide and euthanasia. By sharing the master's thought, we felt the need to make a more open reflection by putting heart and soul into it
The functional activity of the rat c-Ha-ras promoter requires the coordinate involvement of multiple elements
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Nucleotide sequence snd characterization of the 5' flanking region of the rat Ha-ras protooncogene
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