1,720,984 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Novel Therapeutic Approaches to Overcome Acquired Resistance to Enzalutamide in Patients with Advanced Prostate Cancer
No full textThis thesis addresses the development of novel therapeutic approaches to combat acquired resistance to enzalutamide, a second-generation androgen receptor antagonist (SG-ARA), in patients with advanced prostate cancer. Numerous mechanisms of acquired resistance to enzalutamide have been identified via extensive research efforts, including alterations to the androgen receptor (AR), DNA repair, PI3K/AKT, and WNT/β-catenin pathways. An open-label phase 2 clinical trial evaluating the safety and efficacy of seviteronel, a selective CYP17 lyase inhibitor with activity against AR point mutations associated with enzalutamide resistance (e.g., F877L, T877A), was initiated in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with enzalutamide. Overall, seviteronel was not generally well tolerated and did not demonstrate clinically meaningful anti-tumor activity based on prostate-specific antigen (PSA) response, suggesting limited benefit of solely targeting of the AR pathway in patients with advanced prostate cancer following enzalutamide monotherapy. To alternatively overcome enzalutamide resistance, it was proposed to target of hypoxia-inducible factor (HIF)-1α, a transcription factor upregulated in hypoxic tumors and previously shown to interact with the AR and β-catenin, in combination with enzalutamide. NLG207, a nanoparticle-drug conjugate of the potent topoisomerase I inhibitor with HIF-1α modulating properties, camptothecin (CPT), was evaluated in combination with enzalutamide for anti-tumor activity in two preclinical prostate cancer xenograft models of enzalutamide resistance mechanisms, including AR splice variant expression (e.g. AR-V7) and AR overexpression. The addition of NLG207 enhanced the in vivo anti-tumor activity of enzalutamide, significantly reducing tumor volume after three weeks of treatment. Correlative in vitro analyses supported the effectiveness of NLG207 to drive down enzalutamide resistance via the downregulation of AR-V7 mRNA expression. These data provided scientific rationale to investigate dual targeting of HIF-1α and the AR via combination treatment with NLG207 and enzalutamide in a clinical trial setting. To support the clinical investigation of NLG207, a novel, robust, selective, accurate, and precise bioanalytical method to quantify CPT concentrations, both bound and unbound to NLG207, was developed and validated. Clinical samples from 27 patients receiving NLG207 on two National Cancer Institute sponsored clinical trials (NCT02769962 and NCT03531827) were quantitated via the validated bioanalytical method and used to build a population pharmacokinetic (popPK) model via non-linear mixed-effects modelling. The popPK model confirmed the nanoparticle behavior critical to drug delivery facilitated by NLG207 and mechanistically characterized the release of CPT. NCT03531827 is an ongoing open-label phase 2 study with a lead-in dose escalation evaluating the efficacy of NLG207 in combination with enzalutamide in patients with mCRPC previously treated with enzalutamide, with only three patients enrolled to date. The primary objective of the study seeks to improve the overall response rate in this patient population, with response defined as either a PSA decline greater than 50% or stable disease on imaging after 5 months. The study will also evaluate numerous biomarkers of enzalutamide resistance, including those associated with the AR, HIF-1α, and DNA repair pathways. Through increased understanding of acquired resistance to enzalutamide, the collective work aims to facilitate further optimization of treatment for patients with advanced prostate cancer
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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