644 research outputs found
Impaired neural development in a zebrafish model for lowe syndrome
No full textLowe syndrome, which is characterized by defects in the central nervous system, eyes and kidneys, is caused by mutation of the phosphoinositide 5-phosphatase OCRL1. The mechanisms by which loss of OCRL1 leads to the phenotypic manifestations of Lowe syndrome are currently unclear, in part, owing to the lack of an animal model that recapitulates the disease phenotype. Here, we describe a zebrafish model for Lowe syndrome using stable and transient suppression of OCRL1 expression. Deficiency of OCRL1, which is enriched in the brain, leads to neurological defects similar to those reported in Lowe syndrome patients, namely increased susceptibility to heat-induced seizures and cystic brain lesions. In OCRL1-deficient embryos, Akt signalling is reduced and there is both increased apoptosis and reduced proliferation, most strikingly in the neural tissue. Rescue experiments indicate that catalytic activity and binding to the vesicle coat protein clathrin are essential for OCRL1 function in these processes. Our results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome. © The Author 2011. Published by Oxford University Press. All rights reserved
Correction to: The possibilities and practicalities of professional learning in support of Indigenous student experiences in schooling: A systematic review
No full textCorrection to: The Australian Educational Researcher https://doi.org/10.1007/s13384-019-00313-7
In the original publication of the article, the author group was incorrectly published without the co-authors. The correct author group is “Greg Vass, Kevin Lowe, Cathie Burgess, Neil Harrison, Nikki Moodie”.No Full Tex
Regaining the Initative For Public Service Media
No full textPublic service media is today challenged on every front. Publics and politicians see the commercial approach as the ‘normal’ way to organise broadcasting. There are strong pressures to downsize PSM organisations, to limit investment options, to restrict online and digital operations, to narrow remits to genres and for audiences that are not commercially attractive, and for increasingly intrusive assessment procedures. The principles no longer resonate very widely and there is growing criticism about a decline in distinctiveness. Even among traditional allies, support is flagging and skepticism is growing. In Europe the institution has not yet presented a coherent and convincing strategy attuned for relevance in the 21st century. PSM has lost or is in danger of losing the initiative. At the same time, there are promising efforts to develop PSM in regions and countries lacking a domestic history with PSB – to gain the initiative for building PSM. This 5th RIPE Reader incorporates a wider purview as an outgrowth of proceedings from the RIPE@2010 conference that convened in London 8-11 September to address the theme, Public Service Media After the Recession. The book is divided into four sections, reflecting the varied and distinctive narratives of PSB around the world. CONTENT: Preface Gregory Ferrell Lowe, Jeanette Steemers; Regaining the Initiative for Public Service Media I. Policy Case-Making in the Heartland of PSB Robert G. Picard; The Changing Nature of Political Case-Making for Public Service Broadcasters Lars Nord; Losing the Battle, Winning the War. Public Service Media Debate in Scandinavia 2000-2010 Peter Goodwin; High Noon. The BBC Meets “The West’s Most Daring Government” II. Responding to Environmental Pressures Karen Donders, Caroline Pauwels: Ex Ante Tests. A Means to an End or the End for Public Service Media? David A. L. Levy PSB Policymaking in Comparative Perspective. The BBC and France Télévisions Peter Lunt, Sonia Livingstone, Benedetta Brevini Changing Regimes of Regulation. Implications For Public Service Broadcasting III. Taking the Initiative at the Frontiers of PSM Sally Broughton Micova; Born into Crisis. Public Service Broadcasters in South East Europe Yik Chan Chin, Matthew D. Johnson; Public Cultural Service. New Paradigms of Broadcasting Policy and Reform in the People’s Republic of China Julio Juárez-Gámiz, Gregory Ferrell Lowe;Breaking the Mold with New Media. Making Way for a Public Service Provider in Mexico? Naomi Sakr; Public Service Initiatives in Arab Media Today IV. Public Service Media in Practice Steven Barnett; Broadcast Journalism and Impartiality in the Digital Age. Six Fallacies and a Counter-Factual James Bennett, Paul Kerr; A 360° Public Service Sector? The Role of Independent Production in the UK’s Public Service Broadcasting Landscape Piet Bakker; Expectations, Experiences & Exceptions. Promises and Realities of Participation on Websites The Author
Defining absolute environmental limits for the built environment
No full textThe question addressed is whether it is possible to define working limits on environmental impacts from the built environment in terms of global carrying capacity. The main focus is on energy-related impacts, since these are global and relatively well-understood. Four possible approaches to defining limits are explored: static equilibrium, asymptotic, integral of excess and planned future. The conclusions that emerge from this exploration are that global environmental constraints are very tight, but also that they are dynamically and strongly influenced by the trajectory of social and technological development over the coming century. Their use as the basis for practical, quantitative metrics of sustainability, therefore, involves a large measure of subjectivity. A fifth approach - the developmental approach - is identified, which instead of focusing on long-term external constraints to human activity, focuses instead on the internal, short- to medium-term dynamics of the built environment itself. It appears likely that the developmental approach, guided by qualitative conclusions from the analysis of global carrying capacity, is likely to be most fruitful
Distribution Dilemmas for Public Service Media: Evidence from the BBC
No full textThis chapter draws on critical infrastructure studies to deliberate on the growing importance of the distribution of public service media content in the networked society and encourage citizen-user engagement in distribution. The author critiques the notion of ‘networked society’ and examines the emerging television environment to draw attention to transformations as well as persistent continuities. The complexity of media distribution creates dilemmas for public service media, as the BBC case study shows. If public service media is about content that is critical to the functioning of democratic societies, for enhancing social cohesion and promoting cultural diversity through in- vestment in original content, then how that content is found and how it reaches people are crucially important questions. In short, the distribution of, and the terms of access to, public service media content has significant public interest implications which are the focus of this chapter
Correction to: ‘Aboriginal Voices’: An overview of the methodology applied in the systematic review of recent research across ten key areas of Australian Indigenous education (The Australian Educational Researcher, (2019), 46, 2, (213-229), 10.1007/s13384-019-00307-5)
No full textIn the original publication of the article, the author name “Cathie Burgess” was inadvertently missed in the author group. The correct author group is “Kevin Lowe · Christine Tennent · John Guenther · Neil Harrison · Cathie Burgess · Nikki Moodie · Greg Vass”. Cathie Burgess coordinates Aboriginal Studies, Aboriginal Community Engagement and the Master of Education: Leadership in Aboriginal Education programs at the University of Sydney. Cathie’s research involves community-led initiatives positioning Aboriginal cultural educators as experts through projects such as Learning from Country in the City, Aboriginal Voices: Insights into Aboriginal Education and Redfern Cultural Program. The original article has been corrected
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