11 research outputs found
Focus on the good: Positive attentional bias modification for depression
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191308.pdf (Publisher’s version ) (Closed access)Radboud University, 15 juni 2018Promotores : Spijker, J., Becker, E.S., Rinck, M.215 p
Eye-tracking based attention bias modification (ET-ABM) facilitates disengagement from negative stimuli in dysphoric individuals
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191822.pdf (Publisher’s version ) (Open Access)To address shortcomings of purely reaction-time based attention bias modification (ABM) paradigms, a novel eye-tracking based ABM training (ET-ABM) was developed. This training targets the late disengagement from negative stimuli and the lack of attention for positive information, which are characteristics of depression. In the present study, 75 dysphoric students (BDI >= 9) were randomly assigned to either this positive training (PT), or a sham-training (ST) that did not train any valence-specific gaze pattern (positive and negative pictures had to be disengaged from and attended to equally often). Results showed that the PT induced a positive attentional bias (longer fixations of positive than negative pictures). Although the ST group showed an increase in positive attentional bias as well, this increase was not as strong as in the PT group. Compared to the ST, the PT specifically induced faster disengagement from negative pictures. No differential training effects were found on stress responses or state rumination. These results show that the ET-ABM successfully modifies attentional processes, specifically late disengagement from negative stimuli, in dysphoric students, and hence might be a promising alternative to existing ABM paradigms.13 p
Can't look away: An eye-tracking based attentional disengagement training for depression
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159637.pdf (Publisher’s version ) (Open Access)To address shortcomings of purely reaction-time based attentional bias modification (ABM) paradigms, we developed an ABM task that is controlled by eye-tracking. This task allows to assess and train both disengagement from negative pictures and maintained attention to positive pictures. As a proof-of-principle study with an unselected student sample, this positive training (PT; N = 44) was compared to a negative training (NT; N = 42), which reinforced the opposite attentional pattern. Importantly, training trials were completed only if participants performed the correct gaze patterns. Results showed that higher depression levels were associated with slower disengagement from negative stimuli at baseline. As expected, the PT induced longer fixations on positive pictures and faster disengagement from negative pictures. The NT showed no changes in attentional processes. The groups did not differ in mood reactivity and recovery from a stressor. Advantages of using eye-tracking in ABM and potential applications of the training are discussed.15 p
Investigating the (cost-) effectiveness of attention bias modification (ABM) for outpatients with major depressive disorder (MDD): a randomized controlled trial protocol
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167902.pdf (Publisher’s version ) (Open Access)BACKGROUND: Despite the range of available, evidence-based treatment options for Major Depressive Disorder (MDD), the rather low response and remission rates suggest that treatment is not optimal, yet. Computerized attention bias modification (ABM) trainings may have the potential to be provided as cost-effective intervention as adjunct to usual care (UC), by speeding up recovery and bringing more patients into remission. Research suggests, that a selective attention for negative information contributes to development and maintenance of depression and that reducing this negative bias might be of therapeutic value. Previous ABM studies in depression, however, have been limited by small sample sizes, lack of long-term follow-up measures or focus on sub-clinical samples. This study aims at evaluating the long-term (cost-) effectiveness of internet-based ABM, as add-on treatment to UC in adult outpatients with MDD, in a specialized mental health care setting. METHODS/DESIGN: This study presents a double-blind randomized controlled trial in two parallel groups with follow-ups at 1, 6, and 12 months, combined with an economic evaluation. One hundred twenty six patients, diagnosed with MDD, who are registered for specialized outpatient services at a mental health care organization in the Netherlands, are randomized into either a positive training (towards positive and away from negative stimuli) or a sham training, as control condition (continuous attentional bias assessment). Patients complete eight training sessions (seven at home) during a period of two weeks (four weekly sessions). Primary outcome measures are change in attentional bias (pre- to post-test), mood response to stress (at post-test) and long-term effects on depressive symptoms (up to 1-year follow-up). Secondary outcome measures include rumination, resilience, positive and negative affect, and transfer to other cognitive measures (i.e., attentional bias for verbal stimuli, cognitive control, positive mental imagery), as well as quality of life and costs. DISCUSSION: This is the first study investigating the long-term effects of ABM in adult outpatients with MDD, alongside an economic evaluation. Next to exploring the mechanism underlying ABM effects, this study provides first insight into the effects of combining ABM and UC and the potential implementation of ABM in clinical practice. TRIAL REGISTRATION: Trialregister.nl, NTR5285 . Registered 20 July 2015.15 p
Working mechanisms of a general positivity approach-avoidance training: Effects on action tendencies as well as on subjective and physiological stress responses
No full textBackground and Objectives: The general positivity training, a Cognitive Bias Modification procedure modifying individuals' approach-avoidance tendencies to positively and negatively valenced pictures by means of a joystick task, has been proven effective in attenuating stress reactivity in dysphoric students. The present study explored which training component (pull positive pictures, push negative pictures, or both) is the active one in changing action tendencies and stress responses. Methods: Two-hundred-and-thirteen students completed one of four approach-avoidance trainings before being exposed to a stressful speech-task: The general positivity training (pull positive and push negative pictures), a training to approach positive pictures and avoid empty pictures (ApP), a training to avoid negative pictures and approach empty pictures (AvN), or a sham-training. Results The pattern of results suggests that the groups trained to avoid negative pictures showed a stronger increase in positive approach-avoidance tendencies than the other two groups. However, only the positivity training induced significant within-group changes in positive bias. The groups further did not differ in self-report or cardiovascular measures of anxiety in response to the stress-task. Instead, the training affected mood directly: Exposure to negative pictures during the training increased state anxiety. Limitations: Generalizability of the findings is limited by using an unselected student sample. Also, the use of empty pictures as neutral stimuli in the ApP and AvN could have weakened training effects in these groups. Conclusions: Although our results hint at the importance of avoiding negative pictures for modifying an approach-avoidance bias, only the positivity training with both components may effectively induce a positive bias. Remarkably, we failed to replicate and extend previously reported effects of the training on stress-responses. Hence, it remains questionable whether the changes in bias reflect changes in underlying cognitive processing tendencies or task-specific learning effects
Two new Phytophthora species from South African Eucalyptus plantations
No full textA recent study to determine the cause of collar and root rot disease outbreaks of cold tolerant Eucalyptus species in South Africa resulted in the isolation of two putative new Phytophthora species. Based on phylogenetic comparisons using the ITS and β-tubulin gene regions, these species were shown to be distinct from known species. These differences were also supported by robust morphological characteristics. The names, Phytophthora frigida sp. nov. and Phytophthora alticola sp. nov. are thus provided for these taxa, which are phylogenetically closely related to species within the ITS clade 2 (P. citricola, P. tropicali and P.multivesiculata) and 4 (P. arecae and P. megakarya), respectively. Phytophthora frigida is heterothallic, and produces stellate to rosaceous growth patterns on growth medium, corraloid hyphae, sporangia with a variety of distorted shapes and has the ability to grow at low temperatures. Phytophthora alticola is homothallic and has a slower growth rate in culture. Both P. frigida and P. alticola are pathogenic to Eucalyptus dunnii. In pathogenicity tests, they were, however, less pathogenic than P. cinnamomi, which is a well-known pathogen of Eucalyptus in South Africa
A randomized controlled trial of a standard 4-week protocol of repetitive transcranial magnetic stimulation in severe treatment resistant depression
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219107.pdf (Publisher’s version ) (Open Access)Background: Treatment options for major depressive disorder (MDD) in individuals who are depressed for at least 2 years and failed two or more different types of therapeutic intervention, remain scarce. Being less invasive than electroconvulsive therapy, repetitive transcranial magnetic stimulation (rTMS) might be an alternative treatment option. Research Question: Does high frequency rTMS applied over the left prefrontal cortex ameliorate depressive symptoms in patients with treatment resistant major depressive disorder and is the efficacy dependent on treatment resistance? Method: We performed a randomized controlled trial investigating the effect of twenty sessions of real or sham-rTMS, during 4 consecutive weeks. Efficacy was blindly rated with the Hamilton depression rating scale (HDRS-17) at baseline and 1 week after end of treatment, and the Dutch method for quantification of treatment resistance in Depression (DM-TRD) was assessed at baseline. Results: An interim analysis showed no differences in antidepressant response between real and sham rTMS and we therefore discontinued the RCT after 31 patients. The mean difference of the HDRS score between baseline and post-treatment was 3.7 (± 4.0; change 16%), indicating a small but significant improvement across time (F(1,30)=25.4;p<0.01). There were no differences however between the treatment arms (F(1.30)=1.5;p=0.23). We did find a negative correlation between the change in HDRS score and DM-TRD in the active rTMS group, but this correlation was not significantly different from the sham group. Conclusion: "Standard" 4-week rTMS treatment is not effective in chronic, severe treatment-resistant depressed patients. While a replication of our data in this patient group may be ethically difficult, further research with less treatment resistant patients might help in positioning rTMS within the current stepped care approach to depression.6 p
A cognitive control training as add-on treatment to usual care for depressed inpatients
No full textBackground There is a growing body of research supporting the potential therapeutic value of the Cognitive Control Training (CCT) for depression, even though more research including a control condition is necessary to investigate its working mechanisms. Methods The aim of this randomized, double-blind, placebo-controlled trial was to investigate the adjunctive effects of CCT to treatment-as-usual, compared to a sham-training, in patients with Major Depressive Disorder. Hundred-and-fifteen inpatients were randomly assigned to complete ten sessions of either an active working-memory based CCT (n = 56) or a comparable sham-training (n = 59). Changes in depressive symptoms and rumination were assessed from baseline to post-training, and at 1 year follow-up. Secondary outcome measures included alternative indices of maladaptive emotion regulation strategies, state-rumination in response to a worry induction, a cognitive transfer task and self-reports of work-status and well-being at 1 year follow-up. Results Our results show no evidence for short-term beneficial effects of CCT in depressed inpatients when added to TAU. Conclusion Although other studies suggest that CCT may hold potential as an add-on intervention for depression, our findings point to the importance of investigating individual differences and conditions predicting training response
Always approach the bright side of life: A general positivity training reduces stress reactions in vulnerable individuals
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155601.pdf (Publisher’s version ) (Open Access)Emotional disorders are characterized by cognitive biases towards negative stimuli, and a lack of biases towards positive ones. Therefore, we developed a cognitive bias modification training, modifying approach-avoidance tendencies to diverse emotional pictures. In Study 1, a negative training (pull negative, push positive pictures) was compared to a positive training (vice versa) in 141 students. The pre-existing positivity bias remained after positive training, but reversed into a negativity bias after negative training. This effect transferred to an attentional bias. The training affected neither mood nor emotional vulnerability to stress. In Study 2, we investigated the effects of the positive training in 102 dysphoric and non-dysphoric students, all in a sad mood state. Compared to placebo training, the positive training strengthened a positivity bias, and it reduced emotional vulnerability in dysphoric students. This suggests potential therapeutic value of the training, but further studies are needed.15 p
Characteristics of meat, pet, and research rabbit farms in Brazil: An overview based on twelve farms
No full text[EN] Rabbit production has great growth potential in a country where animal production is very important. However, there is little data about this industry in Southern and Southeast Brazil. The aim of this study was to describe Brazilian rabbit farms that provide meat, pets and animals for learning or research. Three pet farms, four meat farms and five research rabbit farms were visited, and the production and farm characteristics data were collected between June 2018 and March 2019. A total of 1170 rabbits and 617 cages were evaluated. Most farms had 21 to 60 (58.3%) does. Considering all farms, the farmers reported an average rate of conception of 71.8%, prolificacy rate of 6.7 kits per parturition, average interval between parturitions of 65 d and 6.3 parturitions/doe yr. The mean mortality rate for breeding rabbits was 10.4%, compared to 1.7% for growing rabbits (rabbits post-weaning until slaughter or sale). The average area of a cage was 0.43±0.1 m², with an average stocking density for growing rabbits of 3 rabbits/m². The most common cage system used by farmers was a flat-deck (66.7% of farms) system with a wire cage (91.7%). Metal (41.7%) and clay (33.3%) feeders were the most common types of feeders, and automatic nipple drinkers were present in 75% of the farms. Dirt accumulation was observed in 11.2% of the cages and 5.7% of the drinkers, but not in feeders. A total of 4.1% of the cages were considered unsafe, and 0.8% had problems with the drinkers. The farms studied ranged from small to medium in size, used an extensive reproductive rhythm and followed basic production techniques. Animal health and management aspects need to be reviewed by the farmer if the rabbit production conditions are to improve.: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) – Finance Code 001. 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