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    Whole DNA methylation on human oocytes retrieved at different maturation stages after superovulation

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    DNA methylation is the most widely investigated epigeneticmodification associated with the repression of endogenous retrotransposons,the stabilization of X-chromosome inactivation, the centromere function andthe overall regulation of genes expression. By acting as an important molecularmark underlying the parental-specific expression of genes subjected to genomicimprinting, DNA methylation plays a significant role in regulating gametematuration, fertilization, embryo growth and placental function. In fact,maternal and paternal imprinted genes are essential for a normal development.Even if recent studies have shown that complete DNA methylation of someimprinted genes occurs only at metaphase II (MII) stage, immature oocytesare highly methylated. The aim of this work was to compare the whole DNAmethylation profile between human germinal vesicle (GV) oocytes andhuman MII oocytes retrieved after ovarian hyperstimulation, in order to investigatewhether differences in the acquisition of an epigenetic profile should berelated to the meiotic maturation stage.[...

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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